Breakthroughs and Discoveries
Dr. Gunderson and his research team recently discovered that pancreatic ductal adenocarcinoma (PDAC) patients with mature tertiary lymphoid structures (TLS) are long-term survivors associated with superior B cell immunity and immunogenic antigen expression. This is important because it shows that pancreatic cancer can be controlled by endogenous immunity and generates hypotheses for how to elicit TLS in all PDAC patients as well as what immunotherapies to which TLS formation may sensitize their cancers.
Dr. Gunderson’s articles and papers have been presented at numerous national and international biomedical and clinical conferences, and they’ve translated into multiple clinical trial protocols. Additionally, his work has been published in multiple peer-reviewed journals, including:
- Nature Communications
- Cancer Discovery
- Cancer Cell
- Oncoimmunology
- Lancet Oncology
Publications include:
Tomoko Yamazaki, Andrew J. Gunderson, Miranda Gilchrist, Mark Whiteford, Maria X. Kiely, Amanda Hayman, David O’Brien, Rehan Ahmad, Jeffrey V. Manchio, Nathaniel Fox, Kayla McCarty, Michaela Phillips, Evelyn Brosnan, Gina Vaccaro, Rui Li, Miklos Simon, Eric Bernstein, Mary McCormick, Andrea Burt, Lena Yamasaki, Ashley Drokin, Trevor Carnahan, Yy To, Will Redmond, Brian Lee, Jeannie Louie, Eric Hansen, Matthew Solhjem, Julie Cramer, Walter Urba, Michael J. Gough, Marka R. Crittenden, Kristina H. Young. A Phase II trial of TGFβ Type I Receptor Inhibitor, Galunisertib, plus Neoadjuvant Chemoradiation in Patients with Locally Advanced Rectal Cancer. The Lancet Oncology, 2022.
Chunhong Zheng , Joseph N Fass, Yi-Ping Shih , Andrew J. Gunderson, Nelson Sanjuan Silva, Huayu Huang, Brady M Bernard, Venkatesh Rajamanickam, Joseph Slagel, Carlo B Bifulco, Brian Piening, Pippa H A Newell, Paul D Hansen, Eric Tran. Transcriptomic profiles of neoantigen-reactive T cells in human gastrointestinal cancers. Cancer Cell, 2022.
Andrew J. Gunderson, Venkatesh Rajamanickam, Cynthia Bui, Joanna Pucilowska, Carmen Ballesteros-Merino, Mark Schmidt, Kayla McCarty, Michaela Philips, Brian Piening, Christopher Dubay, Terry Medler, Phillipa Newell, Paul Hansen, Ephraim Tang, Carlo Bifulco, Marka Crittenden, Michael Gough, and Kristina Young. Germinal center reactions in tertiary lymphoid structures associate with neoantigen burden, humoral immunity, and long-term survivorship in pancreatic cancer. Oncoimmunology, 2021.
Andrew J. Gunderson, Tomoko Yamazaki, Kayla McCarty, Nathaniel Fox, Michaela Phillips, Alejandro Alice, Tiffany Blair, Mary McCormick, Andrea Burt, Iliana Gonzalez, Mark Whiteford, David O’Brien, Rehan Ahmad, Maria X. Kiely, Amanda Hayman, Rui Li, Todd Crocenzi, Michael J. Gough, Marka R. Crittenden, Kristina H. Young. TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking. Nature Communications, 2020.
Andrew J. Gunderson, Tomoko Yamazaki, Kayla McCarty, Michaela Phillips, Alejandro Alice, Shelly Bambina, David Friedman, Benjamin Cottam, Pippa Newell, Michael Gough, Marka Crittenden, Pieter Van der Veken, Kristina Young. Blockade of Fibroblast Activation Protein in Combination with Radiation treatment in Murine Models of Pancreatic Adenocarcinoma. PLoS One., 2019.
Gunderson AJ. and Young KH. Exploring optimal sequencing of radiation and immunotherapy combinations. Advances in Radiation Oncology. 2018.
Gunderson AJ, Kaneda M, Tsujikawa T., Nguyen A, Affara NI, Ruffell B, Gorjestani S, Liudahl SM, Truitt M, Olson P, Kim G, Hanahan D, Tempero M, Sheppard B, Irving B, Lannutti BJ, Johnson DM, Varner JA, Coussens LM. BTK-dependent immune cell crosstalk drives pancreas cancer. Cancer Discovery, 2016.