Ruoning Wang Lab

In particular, we focus on understanding the impact of the interplay between cell metabolic programs and cell-signaling cascades in patho-physiological contexts such as oocyte maturation, tumorigenesis and immune response.

Each of our experimental models has unique biological and technical features, including mouse models of human tumors and autoimmune disease (accessible for genetic and pharmacological modulations), frog oocytes (with defined cell cycle stage and accessibillity for direct intracellular injection of biological material) and primary cells such as MEFs, lymphocytes and macrophages (with defined genetic background, accessible to genetic modulation and responsive to various patho-physiological stimulations).

Our current long-term projects include:

• Dissecting the molecular and biochemical nature of metabolic checkpoint, a mechanism of transducing metabolic signals (often reflected by the change of cellular metabolites) to control cell proliferation and death
• Deciphering metabolic reprogramming in immunity and evaluating the impact of metabolic modulation on immunity
• Understand the mechanism and therapeutic aspects of oncogenic addiction and metabolic addiction of pediatric cancer (neuroblastoma, rhabdomyosarcoma, etc.)

Members

Xuyong Chen – Postdoctoral Scientist, Xuyong.Chen@nationwidechildrens.org

Josephin Gnanaprakasam – Postdoctoral Scientist, Josephin.Gnanaprakasam@nationwidechildrens.org

Siwen Kang – Postdoctoral Scientist, Siwen.Kang@nationwidechildrens.org

Lingling Liu, PhD – Research Scientist, Lingling.Liu@nationwidechildrens.org

John Sherman – Graduate Student, John.Sherman@nationwidechildrens.org

Tingting Wang, PhD – Postdoctoral Fellow, Tingting.Wang@nationwidechildrens.org

Ruohan Wu – Graduate Student, Ruohan.Wu@nationwidechildrens.org

Xuequn Xu – Senior Research Associate, Xuequn.Xu@nationwidechildrens.org