Venere Lab

Research Area

Glioblastoma, cancer stem cells, resistance mechanisms to radio- and chemotherapy, DNA damage response and repair, cell cycle, post-translational modifications, chromatin, kinesins, invasion, primary cilia, proteomics, cell and molecular biology, mouse modeling

Research Summary

We employ a model system based on the finding that glioblastoma tumors harbor a subset of cells, termed cancer stem cells, which encompass the most malignant properties of glioblastoma and drive tumor recurrence. Specific projects in the lab include elucidating the role of kinesins in the DNA damage response, understanding how chromatin remodeling factors contribute to resistance to radiation and investigating the pathways involved in the fate switch from invasion to proliferation.