Selected Publications
2024
Xiao T, Lee J, Gauntner TD, Velegraki M, Lathia JD, Hallmarks of sex bias in immuno-oncology: mechanisms and therapeutic implications. Nat Rev Cancer. 2024 May;24(5):338-355. doi: 10.1038/s41568-024-00680-z. Epub 2024 Apr 8. PMID: 38589557.
Song NJ, Chakravarthy KB, Jeon H, Bolyard C, Reynolds K, Weller KP, Reisinger S, Wang Y, Li A, Jiang S, Ma Q, Barouch DH, Rubinstein MP, Shields PG, Oltz EM, Chung D, Li Z. mRNA vaccines against SARS-CoV-2 induce divergent antigen-specific T-cell responses in patients with lung cancer. J Immunother Cancer. 2024 Jan 4;12(1):e007922. doi: 10.1136/jitc-2023-007922. PMID: 38177076.
Zhou L, Velegraki M, Wang Y, Mandula JK, Chang Y, Liu W, Song NJ, Kwon H, Xiao T, Bolyard C, Hong F, Xin G, Ma Q, Rubinstein MP, Wen H, Li Z. Spatial and functional targeting of intratumoral Tregs reverses CD8+ T cell exhaustion and promotes cancer immunotherapy. J Clin Invest. 2024 May 23;134(14):e180080. doi: 10.1172/JCI180080. PMID: 38787791.
2023
Wieland A, Rubinstein MP, Li Z. PD-1-Targeted Immunotherapy: The Ligand Matters. J Immunol. 2023 Oct 1;211(7):1065-1066. doi: 10.4049/jimmunol.2300239. PMID: 37722094.
Azar JH, Evans JP, Sikorski MH, Chakravarthy KB, McKenney S, Carmody I, Zeng C, Teodorescu R, Song NJ, Hamon JL, Bucci D, Velegraki M, Bolyard C, Weller KP, Reisinger SA, Bhat SA, Maddocks KJ, Denlinger N, Epperla N, Gumina RJ, Vlasova AN, Oltz EM, Saif LJ, Chung D, Woyach JA, Shields PG, Liu SL, Li Z, Rubinstein MP. Selective suppression of de novo SARS-CoV-2 vaccine antibody responses in patients with cancer on B cell-targeted therapy. JCI Insight. 2023 Mar 22;8(6):e163434. doi: 10.1172/jci.insight.163434. PMID: 36749632.
2022
Moreau JM 1, Velegraki M, 2, Bolyard C 2, Rosenblum MD 1, Li Z 2Transforming growth factor-β1 in regulatory T cell biology. Sci Immunol 2022 Mar 18;7(69):eabi4613. doi: 10.1126/sciimmunol.abi4613. Epub 2022 Mar 18. PMID: 35302863 PMCID: PMC10552796 DOI: 10.1126/sciimmunol.abi4613.
Wang Y, Johnson KCC, Gatti-Mays ME, Li Z. Emerging strategies in targeting tumor-resident myeloid cells for cancer immunotherapy. J Hematol Oncol. 2022; 15: 118. pubmed: 36031601; PMCID: PMC9420297 Impact Factor: 17.388
Li A, Chang Y, Song NJ, Wu X, Chung D, Riesenberg BP, Velegraki M, Giuliani GD, Das K, Okimoto T, Kwon H, Chakravarthy KB, Bolyard C, Wang Y, He K, Gatti-Mays M, Das J, Yang Y, Gewirth DT, Ma Q(CB), Carbone D, Li Z. Selective targeting of GARP-LTGFβ axis in the tumor microenvironment augments PD-1 blockade via enhancing CD8+ T cell antitumor immunity. J Immunother Cancer. 2022; 10:pubmed: 36096533; PMCID: PMC9472209 Impact Factor: 13.751
Kwon H, Schafer JM, Song NJ, Kaneko S, Li A, Xiao T, Ma A, Allen C, Das K, Zhou L, Riesenberg B, Chang Y, Weltge P, Velegraki M, Oh DY, Fong L, Ma Q, Sundi D, Chung D, Li X, Li Z. Androgen conspires with the CD8 + T cell exhaustion program and contributes to sex bias in cancer. Sci Immunol. 2022 Jul;7(73):eabq2630. doi: 10.1126/sciimmunol.abq2630 https://www.science.org/stoken/author-tokens/ST-593/full
Welker J, Pulido JD, Catanzaro AT, Malvestutto CD, Li Z, Cohen JB, Whitman ED, Byrne D, Giddings OK, Lake JE, Chua JV, Li E, Chen J, Zhou X, He K, Gates D, Kaur A, Chen J, Chou HY, Devenport M, Touomou R, Kottilil S, Liu Y, Zheng P; SAC-COVID Study Team. Efficacy and safety of CD24Fc in hospitalised patients with COVID-19: a randomised, double-blind, placebo-controlled, phase 3 study. Lancet Infect Dis. 2022 May;22(5):611-621. doi: 10.1016/S1473-3099(22)00058-5.
Song NJ, Allen C, Vilgelm AE, Riesenberg BP, Weller KP, Reynolds K, Chakravarthy KB, Kumar A, Khatiwada A, Sun Z, Ma A, Chang Y, Yusuf M, Li A, Zeng C, Evans JP, Bucci D, Gunasena M, Xu M, Liyanage NPM, Bolyard C, Velegraki M, Liu SL, Ma Q, Devenport M, Liu Y, Zheng P, Malvestutto CD, Chung D, Li Z. Treatment with soluble CD24 attenuates COVID-19-associated systemic immunopathology. J Hematol Oncol. 2022 Jan 10;15(1):5. doi: 10.1186/s13045-021-01222-y.PMID: 35012610
Hong F, Lin CY, Yan J, Dong Y, Ouyang Y, Kim D, Zhang X, Liu B, Sun S, Gu W, Li Z. Canopy Homolog 2 contributes to liver oncogenesis by promoting unfolded protein response-dependent destabilization of tumor protein P53. Hepatology. 2022 Jan 5. doi: 10.1002/hep.32318. PMID: 34986508
Zeng C, Evans JP, Chakravarthy K, Qu P, Reisinger S, Song NJ, Rubinstein MP, Shields PG, Li Z, Liu SL. COVID-19 mRNA booster vaccines elicit strong protection against SARS-CoV-2 Omicron variant in patients with cancer. Cancer Cell. 2022 Feb 14;40(2):117-119. doi: 10.1016/j.ccell.2021.12.014. PMID: 34986328
2021
Benej M, Wu J, Kreamer M, Kery M, Corrales-Guerrero S, Papandreou I, Williams TM, Li Z, Graves EE, Selmic LE, Denko NC. Pharmacological Regulation of Tumor Hypoxia in Model Murine Tumors and Spontaneous Canine Tumors. Cancers (Basel). 2021 Apr 3;13(7):1696. doi: 10.3390/cancers13071696. PMID: 33916656; PMCID: PMC8038388.
Petty AJ, Dai R, Lapalombella R, Baiocchi RA, Benson DM, Li Z, Huang X, Yang Y. Hedgehog-induced PD-L1 on tumor-associated macrophages is critical for suppression of tumor-infiltrating CD8+ T cell function. JCI Insight. 2021 Mar 22;6(6):e146707. doi: 10.1172/jci.insight.146707. PMID: 33749663; PMCID: PMC8026184.
Velegraki M, Salem M, Ansa-Addo EA, Wu BX, Li Z. Autocrine transforming growth factor β1 in regulatory T cell biology-gone but not missed. Immunity. 2021 Mar 9;54(3):395-396. doi: 10.1016/j.immuni.2021.02.007. PMID: 33691126.
Ansa-Addo EA, Huang HC, Riesenberg B, Iamsawat S, Borucki D, Nelson MH, Nam JH, Chung D, Paulos CM, Liu B, Yu XZ, Philpott C, Howe PH, Li Z. RNA binding protein PCBP1 is an intracellular immune checkpoint for shaping T cell responses in cancer immunity. Sci Adv. 2020 May 29;6(22):eaaz3865. doi: 10.1126/sciadv.aaz3865. PMID: 32523987; PMCID: PMC7259945.
Velegraki M, Salem M, Ansa-Addo EA, Wu BX, Li Z. Autocrine transforming growth factor β1 in regulatory T cell biology-gone but not missed. Immunity. 2021 Mar 9;54(3):395-396. doi: 10.1016/j.immuni.2021.02.007. PMID: 33691126.
2020
Metelli A, Wu BX, Riesenberg B, et al. Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β. Sci Transl Med. 2020;12(525):eaay4860. doi:10.1126/scitranslmed.aay4860 [PubMed]
Karvar S, Ansa-Addo EA, Suda J, et al. Moesin, an ERM family member, regulates hepatic fibrosis [published online ahead of print, 2019 Dec 20]. Hepatology. 2019;10.1002/hep.31078. doi:10.1002/hep.31078 [PubMed]
2019
Riesenberg BP, Ansa-Addo EA, Gutierrez J, Timmers CD, Liu B, Li Z (2019) Cutting Edge: Targeting Thrombocytes to Rewire Anticancer Immunity in the Tumor Microenvironment and Potentiate Efficacy of PD-1 Blockade, J Immunol ji1900594. 10.4049/jimmunol.1900594. [PubMed]
Salem M, Wallace C, Velegraki M, Li A, Ansa-Addo E, Metelli A, Kwon H, Riesenberg B, Wu B, Zhang Y, Guglietta S, Sun S, Liu B, Li Z (2019) GARP Dampens Cancer Immunity by Sustaining Function and Accumulation of Regulatory T Cells in the Colon, Cancer Res 79, 1178-1190. 10.1158/0008-5472.Can-18-2623. PMC6420855 [PubMed]
Li P, Zhao R, Fan K, Iwanowycz S, Fan H, Li Z, Liu B (2019) Regulation of dendritic cell function improves survival in experimental sepsis through immune chaperone, Innate Immunity 25, 235-243. 10.1177/1753425919840423. [PubMed]
Kellner J, Wallace C, Liu B, Li Z (2019) Definition of a multiple myeloma progenitor population in mice driven by enforced expression of XBP1s, JCI Insight 4. 10.1172/jci.insight.124698. PMC6483640 [PubMed]
2018
Wallace CH, Wu BX, Salem M, Ansa-Addo EA, Metelli A, Sun S, Gilkeson G, Shlomchik MJ, Liu B, Li Z. (2018) B lymphocytes confer immune tolerance via cell surface GARP-TGF-β complex. JCI Insight. doi: 10.1172/jci.insight.99863 [PubMed]
Metelli A, Salem M, Wallace CH, Wu BX, Li A, Li X, Li Z. (2018) Immunoregulatory functions and the therapeutic implications of GARP-TGF-β in inflammation and cancer. J Hematol Oncol. doi: 10.1186/s13045-018-0570-z. Review [PubMed]
2017
Huck JD, Que NL, Hong F, Li Z, Gewirth DT. (2017) Structural and Functional Analysis of GRP94 in the Closed State Reveals an Essential Role for the Pre-N Domain and a Potential Client-Binding Site. Cell Rep. doi: 10.1016/j.celrep.2017.08.079 [PubMed]
Wu BX, Li A, Lei L, Kaneko S, Wallace C, Li X, Li Z. (2017) Glycoprotein A repetitions predominant (GARP) positively regulates transforming growth factor (TGF) β3 and is essential for mouse palatogenesis. J Biol Chem. doi: 10.1074/jbc.M117.797613 [PubMed]
Hong F, Liu B, Wu BX, Morreall J, Roth B, Davies C, Sun S, Diehl JA, Li Z. (2017) CNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response. Nat Struct Mol Biol. doi: 10.1038/nsmb.3458. [PubMed]
Rachidi S, Metelli A, Riesenberg B, Wu BX, Nelson MH, Wallace C, Paulos CM, Rubinstein MP, Garrett-Mayer E, Hennig M, Bearden DW, Yang Y, Liu B and Li Z (2017) Platelets subvert T cell immunity against cancer via GARP-TGFbeta axis. Sci Immunol 2:eaai7911 (featured in the May 2017 cover) [PubMed]
Wang J, Yuan R, Song W, Sun J, Liu D, Li Z (2017) PD-1, PD-L1 (B7-H1) and Tumor-Site Immune Modulation Therapy: The Historical Perspective. J Hematol Oncol 10(1):34. doi: 10.1186/s13045-017-0403-5. Review. [PubMed]
Hong F, Mohammad Rachidi S, Lundgren D, Han D, Huang X, Zhao H, Kimura Y, Hirano H, Ohara O, Udono H, Meng S, Liu B, Li Z (2017) Mapping the Interactome of a Major Mammalian Endoplasmic Reticulum Heat Shock Protein 90. PLoS One 12(1):e0169260. doi: 10.1371/journal.pone.0169260 [PubMed]
Thaxton TE, Fugle CW, Reisenberg B, Zhang Y, Paulos C, Beeson C, Liu B and Li Z (2017) Endoplasmic reticulum Ca2+ control tempers CD4+ T cell activation and augments anti-tumor function. Cancer Immunol Res pii: canimm.0081.2017. doi: 10.1158/2326-6066.CIR-17-0081.
Ansa-Addo E, Zhang Y, Yang Y, Hussey G, Howley B, Sun S, Rockey D, Karvar S, Howe P, Liu B and Li Z (2017) Membrane-organizing protein moesin controls Treg differentiation and anti-tumor immunity via TGF-β signaling. J Clin Invest 127(4):1321-1337. doi: 10.1172/JCI89281. (Highlighted by JCI This Month) [PubMed]
2016
Metelli, A., Wu, B., Fugle, C.W., Rachidi, S., Sun, S., Zhang, Y., Wu, J., Tomlinson, S., Howe, P., Garrett-Mayer, E., Liu, B., and Li, Z. (2016) Surface Expression of TGFβ Docking Receptor GARP Promotes Oncogenesis and Immune Tolerance in Breast Cancer. Cancer Res. [PubMed]
Fugle, C.W., Zhang, Y., Hong, F., Sun, S., Westwater, C., Rachidi, S., Yu, H., Garret-Mayer, E., Kirkwood, K., Liu, B. and Li, Z. (2016) CD24 blunts oral squamous cancer development and dampens the functional expansion of myeloid-derived suppressor cells. OncoImmunology. [PubMed]
2015
Zhang, Y., Wu, B.X., Metelli, A., Thaxton, J.E., Hong, F., Rachidi, S., Ansa-Addo, E., Sun, S., Vasu, C., Yang, Y. and Liu, B. (2015) GP96 is a GARP chaperone and controls regulatory T cell functions. J Clin Invest, 125(2): 859-869. [PubMed]
Rachidi, S., Sun, S., Wu, B. X., Jones, E., Drake, R. R., Ogretmen, B., Cowart, A., Clarke, C., Hannun, Y., Chiosis, G., Liu, B., Li, Z. (2015). Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis. J Hepatol, 62(4), 879–888. [PubMed]
Su EW, Moore CJ, Suriano S, Johnson CB, Patterson A, Neitzke D, Songalia N, Garrett-Mayer E, Mehrotra S, Paulos CM, Doedens AL, Goldrath AW, Li Z, Cole DJ and Rubinstein MP (2015) IL-2Ralpha mediates temporal regulation of IL-2 signaling and enhances immunotherapy. Sci Transl Med 7(311):311ra170 [PubMed]
2014
Thaxton, J. E., Liu, B., Zheng, P., Liu, Y., & Li, Z. (2014). Deletion of CD24 impairs development of heat shock protein gp96 -driven autoimmune disease through expansion of myeloid derived suppressor cells. J Immunol. 192(12), 5679–5686. [PubMed]
Morales, C., Rachidi, S., Hong, F., Sun, S., Ouyang, X., Wallace, C., Zhang, Y., Garret-Mayer, E., Wu, J., Liu, B. and Li, Z. (2014) Immune chaperone gp96 drives the contributions of macrophages to inflammatory colon tumorigenesis. Cancer Res, 74(2): 446-459. [PubMed]
Rachidi, S., Wallace, K., Day, T.A., Alberg, A.J. and Li, Z. (2014) Lower circulating platelet counts and antiplatelet therapy independently predict better outcomes in patients with head and neck squamous cell carcinoma. J Hematol Oncol, 27(7): 65. [PubMed]