Comparative and Translational Animal Models Shared Resource

Director: Ian C. Davis, BVSc, PhD, ATSF
Blue Buffalo Clinical Trials Office Coordinators: Tamra Mathie (BS, RVT, CFVP, FFCP); Ali Moeller (RVT); Liz Keckley (RVT, RLATG, FFCP (Veterinary), CFVP)

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The overriding goal of this resource is to advance the diagnosis and treatment of disease in veterinary patients while enhancing the health of humans through comparative and translational studies.

CTAMSR’s Goals

• Provide guidance for clinical trial design, including: formulation of a testable hypothesis; determination of patient entry criteria; selection of appropriate toxicity assessments; review of appropriate statistical end points; development of an accurate budget
• Confirm compliance with applicable hospital, IRB, and/or IACUC requirements
• Assist with an assessment to determine the risk of adverse events
• Review proposals prior to submission to the Clinical Research Advisory Committee
• Establish and maintain a network of regional specialists, veterinarians, and breed clubs to assist with patient enrollment
• Provide education in GCP, GLP and the requirements of individual organizations sponsoring trials
• Oversee and verify correct and complete data entry, and compliance with established study guidelines
• Provide a structured, centrally organized system of procurement and storage of biospecimens from patients
• Generate and manage a database supporting the annotation of samples to follow for outcome
• Provide samples to Ohio State and Nationwide Children’s Hospital communities for collaborative research