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Shared Resources

Pharmacoanalytical

The Pharmacoanalytical Shared Resource (PhASR) provides affordable access to expertise and state-of-the-art instrumentation for bioanalytical assay development and quantitative sample analysis, experimental design, data analysis and modeling applied in preclinical and clinical research involving (a) The development of novel therapies for cancer treatment and prevention, (b) Chemopreventive or carcinogenic components in food/environmental sources, and (c) Biomarkers relevant to drug therapy, nutrients, food products, and dietary patterns.

Pharmacoanalytical

    Co-Directors:
    Mitch A. Phelps, PhD
    Steven K. Clinton, MD, PhD
    For orders or inquiries, please email phasr@osumc.edu

    Place an Order in eRAMP

    Expertise among the PhASR personnel includes quantitative pharmacology; bioanalytical methodology, design of pharmacokinetic/pharmacodynamic studies in animal disease models and in humans enrolled in clinical trials; data analysis and modeling of PK/PD data to inform drug development decisions. The PhASR personnel are available for consultation on clinical or pre-clinical PK/PD experimental design and analysis.

    Key program objectives

    PhASR’s Specific Aims are to:

    • Aim 1: Develop and update and validate new assays to quantify drugs, metabolites, endogenous biomolecules/biomarkers, environmental carcinogens, nutrients and bioactive phytochemicals in biospecimens, as well as environmental and food sources.
    • Aim 2: Apply validated assays to quantify drug and metabolite concentrations in biological matrices and conduct PK/PD studies for incorporation into preclinical and clinical studies to support evidence-based decision-making.
    • Aim 3: Provide expertise in targeted nutritional lipidomics to support studies of foods and dietary patterns in preclinical, clinical and epidemiologic studies.
    • Aim 4: Provide expertise in study design, biosample procurement and processing, and data analysis and interpretation to support submission of clinical trial protocols, grant applications and publications.

    Contact PhASR

    Pharmacoanalytical Shared Resource
    College of Pharmacy, Division of Pharmaceutics
    241 Parks Hall
    500 W. 12th Ave.
    Columbus, OH 43210

    441 Biomedical Research Tower
    460 W. 12th Ave.
    Columbus, OH 43210

    phasr@osumc.edu

    Availability: Monday-Friday, 8 a.m.-5 p.m.

    This Shared Resource is supported by the Cancer Center Support Grant (P30CA016058).