A major benefit of having one of the world’s leading and largest digital pathology programs is the impact the OSUCCC – James can have on research and medical advances.
Digital pathology has expanded our research capabilities, allowing our researchers to assemble cohorts more rapidly, inquire about larger volumes of cases and explore specimens more deeply, quickly and accurately than ever before.
Our digital pathology team, with each member possessing a specialized focus and background, publishes dozens of research findings annually. Some of these publications detail how the OSUCCC – James has built and utilized a successful digital pathology program while others look at clinical uses of the technology, such as analyzing suspicious-looking areas of biopsies to predict prostate cancer.
Here, you’ll find some of that groundbreaking work.
Digital and Computational Pathology Publications
McCall S, Chuaqui R, Lubensky I, Moskaluk C, Parwani A, Radin K, Ramirez N, Von Menchhofen Z, Washington M, LiVolsi V. The Cooperative Human Tissue Network of the National Cancer Institute: supporting cancer for 35 years. United States and Canadian Academy of Pathology Annual Meeting, New Orleans, LA, Mar 11-16, 2023.
Sukrithan V, Boateng I, Jain P, Liyanarachchi S, Buss J, Parwani A, Shah M, Konda B, Brock P, Eisfeld AK. Germline whole-exome sequencing of patients with neuroendocrine neoplasms reveals pathogenic or likely pathogenic variants in a large subset of patients. 20th Annual European Neuroendocrine Tumor Society (ENETS) Conference, Vienna, Austria, Mar 22-24, 2023. (Submitted – pending.)
Mandt RL, Nohle DG, Couce M, Dhir R, Shilo K, Ayers LW, Parwani AV. Increased requests for fresh samples impact the workflow for the Cooperative Human Tissue Network (CHTN) Midwestern Division. International Society for Biological and Environmental Repositories (ISBER) Annual Meeting, Seattle, WA, May 3-6, 2023.
Belcher S, Mandt RL, Nohle DG, Ayers LW, Couce M, Dhir R, Parwani AV. A ten-year review of a prospective procurement biospecimen IRB and the influence on specimen procurement and distribution at the Cooperative Human Tissue Network (CHTN) Midwestern Division. International Society for Biological and Environmental Repositories (ISBER) Annual Meeting, Seattle, WA, May 3-6, 2023.
Patel AU, Mohanty SK, Parwani AV. Applications of digital and computational pathology and artificial intelligence in genitourinary pathology diagnostics. Surg Pathol Clinics. 2022 Dec;15(4):759-785. doi: 10.1016/j.path.2022.08.001. PMID: 36344188
Corps K, Parwani A. Comparative Pathology & Digital Imaging Shared Resource (CPDISR). OSU Comprehensive Cancer Center Annual Scientific Meeting, Columbus, OH, Oct 14, 2022.
Nohle DG, Mandt RL, Couce ME, Dhir R, Shilo K, Ayers LW, Parwani AV. Progress in biobanking with the Cooperative Human Tissue Network (CHTN) Midwestern Division to enable pathologist-supervised distribution of high quality tissues for basic and translational research 2017-2021. OSU Comprehensive Cancer Center Annual Scientific Meeting, Columbus, OH, Oct 14, 2022. (Poster 160)
Nohle DG, Mandt RL, Shilo K, Ayers LW, Parwani AV. Deployment of a Cooperative Human Tissue Network (CHTN) whole slide image (WSI) repository using PathPresenter. OSU Comprehensive Cancer Center Annual Scientific Meeting, Columbus, OH, Oct 14, 2022. (Poster 159)
Vazzano J, Hu K, Johansson D, Eurén K, Zhou M, Parwani A. INIFY prostate predictions on prostate biopsy – performance and effectiveness study on WSIs from two pathology laboratories in US. Pathology Visions 2022, Las Vegas, NV, Oct 16-18, 2022.
Satturwar S, Mishra M, Hammond S, Lujan G, Li Z, Singh R, Batenchuk C, Parwani A. Validation of Path Presenter’s clinical consult portal for digital pathology consultation service at an academic institution. Pathology Visions 2022, Las Vegas, NV, Oct 16-18, 2022.
Arole V, Kulewsky J, Caldara J, Scarl R, Satturwar S, Li Z, Chen W, Parwani A, Lujan G. Automated artificial intelligence-based analysis to support clinical assessments of Ki-67 immunohistochemistry-stained neuroendocrine tumors in the routine workflow. Pathology Visions 2022, Las Vegas, NV, Oct 16-18, 2022.
Parwani AV, Mandt R, Nohle DG, Shilo K, Bhatia L, Rangwani N. Building a cloud-based whole slide image repository marketplace for easier image management, annotations, and distribution for basic science and translational research. Pathology Visions 2022, Las Vegas, NV, Oct 16-18, 2022.
Arole V, Ziebell J, Parkinson B, Dai H, Li Z, Parwani A, Satturwar S, Gamble D, Vazzano J, Kumar A, Yearsley M, Frankel W, Schoenfield L, Mishra M, Sun S, Kneile J, Reuss S, Schumacher M, Chen W, Lujan G. Comparing helicobacter pylori identification using traditional glass slides vs digital whole slide imaging. Pathology Visions 2022, Las Vegas, NV, Oct 16-18, 2022.
Mandt R, Parwani AV, Shilo K, Bhatia L, Hammond S, Nohle DG, Ayers LW. A digital pathology biobanking workflow enables and image-based data sharing with or without procured research tissues, 2017-2021. Pathology Visions 2022, Las Vegas, NV, Oct 16-18, 2022.
Shaker N, Satturwar S, Lujan G, Parwani A. Whole slide imaging of genitourinary pathology for educational purposes. Pathology Visions 2022, Las Vegas, NV, Oct 16-18, 2022.
Gullapalli R, Parwani A. Biases and AI-enabled digital pathology workflows: surveying the current landscape. Pathology Visions 2022, Las Vegas, NV, Oct 16-18, 2022.
Gullapalli RR, Laharwani H, Parwani AV. Trustworthy AI frameworks in digital pathology: the path forward? Pathology Visions 2022, Las Vegas, NV, Oct 16-18, 2022.
Shaker N, Kellough D, Hammond S, Walsh J, Kipp K, Lombardo A, Palermini E, Pifher M, Whitaker B, Otero J, Yearsley M, Chen W, Satturwar S, Sun S, Shilo K, Shana’ah A, Frankel W, Li Z, Parwani A, Lujan G. A fully implemented digital pathology workflow at a high-volume, high complexity academic medical center: a five-year report card on quality of scanning. Pathology Visions 2022, Las Vegas, NV, Oct 16-18, 2022.
Li M, Patrick S, Pietrzak M, Yin M, Clinton S, Spakowicz D, Parwani A, Li Z, Yang Y, Gheeya J, Mortazavi A. Differential expression and function of toll-like receptor 3 within tumor immune microenvironment of clear cell renal cell carcinoma. Society for Immunotherapy of Cancer (SITC) 37th Annual Meeting, Boston, MA, Nov 8-12, 2022. Abstract published in J Immunotherapy Cancer, 2022 Nov;10(Suppl2):A89-A90. doi: 10.1136/jitc-2022.0082.
Bidgoli AA, Rahnamayan S, Dehkharghanian T, Riasatian A, Kalra S, Zaveri M, Campbell CJV, Parwani A, Pantanowitz L, Tizhoosh HR. Evolutionary deep feature selection for compact representation of gigapixel images in digital pathology. Art Intel Med. 2022 Oct;102368. doi.org/10.1016/j.artmed.2022.102368. Epub 2022 Jul 25. PMID: 36207081
Antonini P, Santonicco N, Pantanowitz L, Girolami I, Chiara Rizzo P, Brunelli M, Bellevicine C, Vigliar E, Giovanni N, Troncone G, Fadda G, Parwani A, Marletta S, Eccher A. Relevance of the College of American Pathologists’ guideline for validating whole slide imaging for diagnostic purposes to cytopathology. Cytopathology. 2022 Sep 8. doi: 10.1111/cyt.13178. Online ahead of print. PMID: 36082410
Parwani AV, Sardana R, Hamasaki S, Nohle DG, Ayers LW. Image analysis is adversely affected by pre-analytical factors such as stained tissue slide and paraffin block age. Pathology Informatics Summit 2022, Pittsburgh, PA, May 9-12, 2022. (Poster)
Shaker N, Nohle DG, Mandt RL, Couce M, Shilo K, Shir R, Ayers LW, Parwani AV. Informatics driven workflow and digital pathology quality review enhances biobanking workflows with the Cooperative Human Tissue Network to augment basic and translational research. Pathology Informatics Summit 2022, Pittsburgh, PA, May 9-12, 2022. (Poster)
Mandt RL, Nohle DG, Shaker N, Couce ME, Dhir R, Shilo K, Ayers LW, Parwani AV. Progress in biobanking with the Cooperative Human Tissue Network (CHTN) Midwestern Division to enable pathologist-supervised distribution of high-quality tissues for basic and translational research. International Society for Biological and Environmental Repositories (ISBER) Annual Meeting, Atlanta, GA, May 16-20, 2022. (Poster)
Mandt RL, Nohle DG, Shaker N, Couce ME, Dhir R, Shilo K, Ayers LW, Parwani AV. The Cooperative Human Tissue Network (CHTN) Midwestern Division uses whole slide images (WSIs) for pathologist QC review of each distributed tissue for lesion type and % tumor. International Society for Biological and Environmental Repositories (ISBER) Annual Meeting, Atlanta, GA, May 16-20, 2022. (Poster)
Parwani AV (Ed). Whole Slide Imaging, Springer Nature; 2021.