The Impact of Your Gift

Thank you for creating a cancer-free world with us.

By supporting the OSUCCC – James, you are making positive changes in the fight against cancer. Your gift is being used to advance our knowledge of cancer through:

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Learn more about the impact you have made in the following areas:

Breast Cancer Cancer Prevention Head and Neck Hematology Lung Melanoma Prostate


Breast Cancer 

Your support of breast cancer research through the Stefanie Spielman Fund for Breast Cancer Research is advancing research efforts in so many ways.

Robert Wesolowski

Your contributions are supporting Robert Wesolowski, MD, medical oncologist, understand how we can supercharge the human immune system to better fight cancer cells inside our bodies.

Our immune systems are constantly fighting infection and cancer. But sometimes, our immune systems react in a way that “protects” cancer cells instead of fighting them. Dr. Wesolowski is investigating a specific protein – BRD4 – and is trying to determine if blocking that protein could stop our immune systems from protecting cancer cells. 


Ramaswamy

Your funding also is helping us examine the ways in which breastfeeding decreases the risk for the most aggressive type of breast cancer, called triple negative breast cancer.

Bhuvana Ramaswamy, MD, medical oncologist, is studying that connection in the hopes of decreasing the risk of triple negative breast cancer, which frequently occurs in young women and particularly affects young African-American women.


Hematology

Our work continues to focus primarily on chronic lymphocytic leukemia, but, thanks to your generosity, we have expanded our work to study acute myeloid leukemia, hairy cell leukemia, multiple myeloma and sickle cell anemia. You have made a number of breakthroughs possible:

Leukemia Research ProgramYour philanthropic support has given us the tools to become one of the main sties working on the Leukemia and Lymphoma Society’s “Beat AML” master trial – a new clinical trial model designed to speed up testing of new treatments for acute myeloid leukemia.

Your generosity has helped purchase critically needed equipment that allows us to identify and separate different cell types from the same sample, allowing us to study cells in isolation. Because of this new technology, we are able to study the ways in which each cell subset contributes to tumor cell survival, giving us more clues as to how diseases like chronic lymphocytic leukemia develop.

Philanthropy has helped us collaborate with The Ohio State College of Veterinary Medicine to study new treatments for lymphoma in dogs. Previous research has shown that drugs that work in dog lymphoma almost always work for humans as well. This partnership is giving us incredible insight into developing the safest, most effective therapies for lymphoma patients.

Your gifts are helping our multiple myeloma research team develop new treatments that turn off the genes and proteins that allow multiple myeloma to spread. Research funding from philanthropy helps us fuel new and existing ideas for creating novel, less toxic treatments. 


Lung Cancer

You are shaping our research programs towards a creating a cancer free world in so many ways. Some highlights:

Lung cancer image_webYour generous gifts are continuing to help Rajeswara Rao Arasada, PhD, find new cures in fighting lung cancer that is resistant to existing targeted therapies. Dr. Arasada has found that targeted therapy (EGFR tyrosine kinase inhibitors) can cause induction of cancer stem cells that can lead to drug resistance. Dr. Arasada has performed a pre-clinical trial and identified a novel combinational therapy that showed strong increase in the disease progression free survival and overall survival rate in animal models. This work has been published in prestigious journal, Nature Communications, 2018.

Philanthropy has helped us lease and purchase equipment including a mass spectrometer, which quickly measures and analyzes protein differences between cancer cells and normal cells, helping David Carbone, MD, PhD’s laboratory discover the next generation of lung cancer therapies.

Philanthropic contributions are also helping Takehito Shukuya, MD,PhD, conduct research to identifying which lung cancer patients are most likely to benefit to immunotherapy and which are not. Because of the generosity of our donors, Dr. Shukuya has been able to collaborate with researchers in both Seattle, Wash. and Germany to conduct this highly patient treatment oriented work, which will help physicians to determine the appropriate treatment options to the right patients.


Prostate Cancer 

Your generosity has advanced research and patient care for patients dealing with prostate cancer in so many ways:

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Your gifts support our multi-disciplinary clinic – an offering unique to Ohio State and one that provides the best possible treatment strategy for each patient. At our clinic, a person with a new diagnosis meets with an array of specialists – from medical oncologists to radiation therapists to urologists – in one single visit. Our goal is to present the range of effective treatment options to each patient, and to help each individual identify the best course of treatment for him.

You are also helping us build, from the ground up, a genetic counseling program specifically for prostate cancer patients and their families. Research has shown that certain genetic traits are likely to be associated with about 10 percent of prostate cancers – and more importantly, certain mutations make you eligible for a pharmacological treatment that would not otherwise be an option. This program is in its infancy, and philanthropy has played – and will continue to play – an important role in establishing innovative programs and in creating more chances to save lives of patients with prostate cancer.

Your support also has helped us develop and improve screening and prevention programs for prostate cancers. Researchers have shown that certain demographic populations are at higher risk of dying from prostate cancer.With your help, we are building research-based programs to bring screening and prevention techniques directly to those populations. Doing so will help us identify prostate cancers sooner, and treat them more effectively.