Altaf A Wani, PhD
College of Medicine
Molecular Carcinogenesis and Chemoprevention
DNA Damage ● Xeroderma Pigmentosum ● Cell Transformation, Neoplastic ● Ovarian Cancer ● Cancer ● Breast Cancer ● Li-Fraumeni Syndrome
Altaf Wani, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where his research focuses on molecular carcinogenesis analysis, fine mapping and cellular processing of DNA damage responses.One of his recent studies revealed an unappreciated regulatory mode involving the interaction between DNA damage-binding protein 2 (DDB2) and developmentally downregulated 4-Like (NEDD4L) in ovarian cancer cells. The novel mechanism suggests DDB2-mediated fine-tuning of transforming growth factor beta signaling and its downstream effects that mitigate ovarian cancer growth. Dr. Wani is the co-author of many articles in well-known publications, including Cell Cycle, Nucleic Acids Research, Molecular Cancer Research and Journal of Biological Chemistry.