Ching-Shih Chen, PhD
College of Pharmacy
Molecular Carcinogenesis and Chemoprevention
Cancer, Prostatic Cancer, Leukemia, Lymphocytic, Chronic, B-Cell, Breast Cancer, Carcinoma, Hepatocellular, Lymphoma, Mantle-Cell
Ching-Shih Chen, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where his research focus is on drug discovery and design by identifying targets in signaling pathways that govern cancer cell survival.His multidisciplinary approach to research has led to the development of small-molecule agents that target molecular defects related to kinase signaling, epigenetics and metabolism in cancer cells. These novel agents influence antiproliferative effects through mechanisms distinct from conventional chemotherapeutic regimens. This understanding will provide a rational approach for molecular-targeted cancer therapy. Dr. Chen has co-authored many articles in well-respected publications such as Journal of the National Cancer Institute, Cancer Research, Clinical Cancer Research, Blood, Science Signaling and Journal of Medicinal Chemistry.