Daniel T Starczynowski, PhD
College of Medicine - UC
Dr. Starczynowski's laboratory focuses on the molecular, cellular, and genetic basis of hematologic malignancies, with a specific focus on Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML). They have uncovered aberrant activation of the innate immune pathway in MDS, and now find that this activation perturbs normal hematopoietic stem/progenitor (HSPC) function. Therefore, one of the main objectives is to evaluate the role of the innate immune pathway in normal HSPC and in MDS. Broader initiatives involve characterizing novel candidate genes relevant to MDS, dissecting molecular and cellular alterations in MDS (and related hematologic malignancies), and attempting to identify novel therapeutics.