Dawn S Chandler, PhD

Research Interest

Cancer ● Muscular Atrophy, Spinal ● Rhabdomyosarcoma ● DNA Damage ● Breast Cancer ● Loss of Heterozygosity ● Anoxia ● Carcinoma, Renal Cell ● von Hippel-Lindau Disease ● Myopathies, Structural, Congenital

Dawn Chandler, PhD, is a member of the Molecular Biology and Cancer Genetics Program at the OSUCCC – James, where her work focuses on the regulation of pre-mRNA splicing and how its disruption can lead to pediatric diseases such as cancer.

In one recent study, her team’s research identified for the first time a clear mechanism for regulating damage-induced oncogene MDM2 splicing. The work offers potential strategies for manipulating MDM2 expression via splicing modulation.

Dr. Chandler has co-authored numerous articles in well-respected publications, including Human Molecular Genetics, Nucleic Acids Research and the Journal of Biological Chemistry.