Dawn S Chandler, PhD

College
College of Medicine
Department/Division
Pediatrics
Academic Title
Assoc Professor
Research Program
Molecular Biology and Cancer Genetics
Research Interest
Cancer, Muscular Atrophy, Spinal, Rhabdomyosarcoma, DNA Damage, Breast Cancer, Loss of Heterozygosity, Anoxia, Carcinoma, Renal Cell, von Hippel-Lindau Disease, Myopathies, Structural, Congenital
Dawn Chandler, PhD, is a member of the Molecular Biology and Cancer Genetics Program at the OSUCCC – James, where her work focuses on the regulation of pre-mRNA splicing and how its disruption can lead to pediatric diseases such as cancer.
In one recent study, her team’s research identified for the first time a clear mechanism for regulating damage-induced oncogene MDM2 splicing. The work offers potential strategies for manipulating MDM2 expression via splicing modulation. Dr. Chandler has co-authored numerous articles in well-respected publications, including Human Molecular Genetics, Nucleic Acids Research and the Journal of Biological Chemistry.Office Location
WA5023 Columbus Children's Research Institute
700 Children's Drive, Columbus, OH 43205