Dehua Pei, PhD
College of Arts & Sciences
Chemistry & Biochemistry
Molecular Carcinogenesis and Chemoprevention
Dehua Pei, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where his research focuses on the molecular basis of biological processes by chemical methods.In particular, he seeks to identify the interaction partners of protein modular domains and the in vivo substrates of protein tyrosine phosphatases. He also looks to create methodology for synthesis, screening and identification of cyclic peptides and peptidomimetics as organocatalysts and for biological activities. One of his recent studies indicates gene-encoding adaptor protein LNK suppression of IL-7R/JAK/STAT signaling to restrict pro- and pre-B progenitor expansion could be a potential therapeutic agent for B-cell acute lymphocytic leukemia with LNK mutations. Dr. Pei has co-authored many articles in well-known publications, including Biochemistry, New England Journal of Medicine, Journal of Medicinal Chemistry and Journal of the American Chemical Society.