F. Kay Huebner, PhD
College of Medicine
Cancer Biology and Genetics
Molecular Biology and Cancer Genetics
Cancer ● DNA Damage ● Carcinoma ● Breast Cancer ● Carcinoma, Renal Cell ● Loss of Heterozygosity ● Leukemia ● Lung Cancer
Kay Huebner, PhD, is a member of the Molecular Biology and Cancer Genetics Program at the OSUCCC – James, where her research focuses on investigating and defining the biological functions of tumor-suppressor proteins.In particular, she is interested in two of the most frequently inactivated tumor suppressors in the broad spectrum of cancer: FHIT and WWOX encoded by the chromosome fragile sites FRA3B and FRA16D. The goal is to identify protein markers and possible therapeutic targets for specific cancers. Very recently, she and her collaborators have shown that the clock-like, ubiquitous ‘cancer mutational signature’ 5 occurs specifically in cancers with deleted FHIT alleles, suggesting that loss of FHIT expression plays roles in initiation of all types of cancer. In researching the WWOX gene with her students and colleagues, her team has found that loss of WWOX expression in cancers makes them more resistant to killing by some DNA-damaging agents used frequently in cancer treatment. Dr. Huebner has co-authored more than 300 articles in well-respected publications, including Cancer Research, Journal of the National Cancer Institute, Carcinogenesis and Genes, Chromosomes and Cancer.