H L Grimes, PhD
College of Medicine - UC
Dr. Grimes was part of a team that first discovered the Growth factor independent-1 transcription factor which controls blood development and cancer, and he has shown that this factor is mutant in children with severe congenital neutropenia (SCN). Children with SCN lack neutrophils, blood cells which fight infection, and are thus prone to bacterial and fungal infections. Moreover, SCN patients are at dramatically increased risk for acute myeloid leukemia. The Grimes lab studies transcriptional and epigenetic signaling circuits in normal and cancerous blood development using human, mouse and fruitfly genetic models to gain insight into ancient pathways that underlie cancer. Using these tools they have 1) generated the first mouse model of SCN, 2) discovered critical genes that are disregulated in SCN, and 3) uncovered a key epigenetic component of myeloid development and transformation to acute myeloid leukemia.