H L Grimes, PhD
College of Medicine - UC
H. Leighton Grimes, PhD, is a Professor in the Division of Immunobiology and Center for Systems Immunology at the Cincinnati Children’s Hospital Medical Center. He is also a member of the Leukemia Research Program at the OSUCCC – James, where his research focuses on transcriptional and epigenetic signaling circuits in normal and cancerous blood development.Dr. Grimes has a broad background in hematopoiesis, molecular biology and molecular oncology, including mouse modeling of hematopoiesis, myelopoiesis, marrow failure syndromes and leukemia. He received a PhD in molecular pathology and immunology, studying gene regulation with Maureen Goodenow, PhD, who was then at the University of Florida, and then he joined Philip Tsichlis, MD, while at Fox Chase Cancer Center. Dr. Grimes participated in the identification of the growth factor independent-1 (Gfi1) transcription factor and its DNA-binding specificity, which is named the “SNAG” transcription repressor domain, and he genetically linked this domain to Gfi1-directed biology. His laboratory continues to focus on transcriptional integration of normal and malignant hematopoiesis, having identified humans with mutations in GfI1 who display severe congenital neutropenia (SCN) and non-immune chronic idiopathic neutropenia of adults (NI-CINA). His lab has recently generated deep single cell RNA Seq (scRNA Seq) datasets from bone marrow stem/progenitor cells and collaborated with Nathan Salomonis, PhD, at Cincinnati Children’s Hospital Medical Center to develop Iterative Clustering and Guide Gene Selection (ICGS), a novel bioinformatics tool for unsupervised scRNA Seq analysis. Using scRNA-Seq and ICGS, his lab dissected homeostatic myeloid development and a rapid, fully penetrant model of cytogenetically normal AML. Dr. Grimes has authored or co-authored many articles in well-respected publications, including Nature, Cancer Discovery, Blood, Leukemia, Journal of Clinical Investigation and Experimental Hematology.