Haitao Wen, MD, PhD
College of Medicine
Microbial Infection & Immunity
Molecular Carcinogenesis and Chemoprevention
A hallmark feature of colorectal cancer (CRC) is enhanced activation of immune signaling and inflammatory cytokine production. Recent studies have established that activated immune cells and cancer cells exhibit similar reprogramming process in glucose metabolism. My lab investigates the function of a unique glucose metabolic enzyme, namely the O-GlcNAc transferase (OGT), in CRC development. Biochemical, genetic, and animal modeling strategies are commonly used in our studies to dissect the individual effect of OGT in the immune system versus tumor cells during CRC development. Due to its targetable nature, OGT may represent a promising therapeutic target for CRC patients.