James C Mulloy, PhD

James Mulloy

College

College of Medicine - UC

Department/Division

Pediatrics

Academic Title

Professor

Research Program

Leukemia Research

Research in the Mulloy Laboratory focuses on using human hematopoietic stem/progenitor cells (HSPC) to model leukemia. The prevailing theory is that acute myeloid leukemia is a stem cell disease. We believe the technology and expertise are now available that permit us to use primary human HSPC to dissect the stepwise progression of human AML. As a proof of principal, we have expressed the AML1-ETO fusion protein in human CD34+ cells by retroviral transduction and characterized the genetic and functional alterations that occur due to expression of this oncogene These studies have recently been extended to two additional oncogenes, CBFb-MYH11 and MLL-AF9.


Education and Background

Office Location

S7.603/ML 7013

3333 Burnet Avenue, Cincinnati, OH 45229


513-636-1844

513-636-3768



Publications

Back to Researcher Search

Please enter a keyword (i.e. Name, Research Interest) or choose a Research Program

OR

Please enter a keyword (i.e. Name, Cancer Type) or choose a Principle Investigator

OR

Search for Clinical Trials

Find a Scientific Publication