James L Chen, MD
College of Medicine
Cancer, Sarcoma, Prostatic Cancer, hemorrhage, Carcinoma, Renal Cell
Dr. Chen’s research explores how translational bioinformatics can be applied to cancer. Specifically, he uses high-throughput genomics to identify molecular pathway deregulations and to predict clinical responses to targeted therapies. His research and clinical focus centers on soft tissue sarcoma as I am one of our two sarcoma medical oncologists. To this end, he is testing a matching algorithm that uses genomic predictors to identify sarcoma patients sensitive to the chemotherapeutic, doxorubicin and/or the targeted agent, pazopanib. Concurrently, he is deciphering the molecular underpinnings of local metastasis in sarcoma using bioinformatics techniques to identify and test potential therapies.