Jeffrey J Chalmers, PhD

College

College of Engineering

Department/Division

Chemical & Biomolecular Engineering

Academic Title

Professor

Research Program

Translational Therapeutics

Research Interest

Cancer, Coronary Disease, Rupture, Alzheimer Disease, Carcinoma, Squamous Cell, Breast Cancer

Jeffrey Chalmers, PhD, is a member of the Translational Therapeutics Program at the OSUCCC – James, where he brings a special perspective from the Chemical and Biomolecular Engineering Department in the College of Engineering.

His research aids in the development of fundamental understanding and applications of the interaction of hydrodynamic and magnetic forces and cells. It ranges from the establishment of mathematical relationships detailing physical phenomena to the development of simple, robust instruments to use in a clinical setting.

Results of one of his recent studies indicate that miR-21 and miR-29a are necessary for pro-tumor functions of myeloid cells, and that the CSF1-ETS2 pathway upstream of the miRs acts as a therapeutic target to inhibit M2 remodeling of macrophages during malignancy.

Dr. Chalmers has co-authored numerous articles in well-respected publications such as Breast Cancer Research, Methods, Journal of Magnetism and Magnetic Materials and Frontiers in Oncology.

Education and Background

Office Location

333B Koffolt Laboratories

140 W 19th Ave, Columbus, OH 43210

614-292-2727

614-292-3769

chalmers.1@osu.edu

Publications

Pharmacy informatics in multihospital health systems: Opportunities and challenges.

Siska M, Chalmers J, Le T, Knoer S

Am J Health Syst Pharm 75 457-464 04/01/2018
Implementing Liquid Biopsies in Clinical Trials: State of Affairs, Opportunities, and Challenges.

Chalmers JJ, Lustberg MB, Stover DG

Cancer J 24 61-64 03/01/2018
Continuous, intrinsic magnetic depletion of erythrocytes from whole blood with a quadrupole magnet and annular flow channel; pilot scale study.

Tanaka T, Mizutani D, Zborowski M, Buck A, Chalmers JJ, Moore LR, Yazer M

Biotechnol Bioeng in press 02/24/2018
Correlation of simulation/finite element analysis to the separation of intrinsically magnetic spores and red blood cells using a microfluidic magnetic deposition system.

Zborowski M, Chalmers JJ, Sun J, Xue W, Moore L, Kim J

Biotechnol Bioeng in press 01/16/2018
Magnetic Quantum Dots Steer and Detach Microtubules from Kinesin-Coated Surfaces.

Mahajan KD, Cui Y, Dorcéna CJ, Bouxsien NF, Bachand GD, Chalmers JJ, Winter JO

Biotechnol J in press 09/23/2017
Mechanotransduction Effects on Endothelial Cell Proliferation via CD31 and VEGFR2: Implications for Immunomagnetic Separation.

Mahajan KD, Nabar GM, Xue W, Anghelina M, Moldovan N, Chalmers J, Winter J

Biotechnol J in press 07/21/2017
Tessellated permanent magnet circuits for flow-through, open gradient separations of weakly magnetic materials.

Williams PS, Moore LR, Chalmers JJ, Zborowski M

J Magn Magn Mater 427 325-330 04/01/2017
Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells.

Zhu X, Badawi M, Pomeroy S, Sutaria DS, Xie Z, Baek A, Jiang J, Elgamal OA, Mo X, Perle K, Chalmers J, Schmittgen TD, Phelps MA

J Extracell Vesicles 6 1324730 01/01/2017
Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery.

Sutaria DS, Jiang J, Elgamal OA, Pomeroy SM, Badawi M, Zhu X, Pavlovicz R, Azevedo-Pouly ACP, Chalmers J, Li C, Phelps MA, Schmittgen TD

J Extracell Vesicles 6 1333882 01/01/2017
Multispectral Imaging Analysis of Circulating Tumor Cells in Negatively Enriched Peripheral Blood Samples.

Miller B, Lustberg M, Summers TA, Chalmers JJ

Methods Mol Biol 1634 219-234 01/01/2017
Effect of surgical intervention on circulating tumor cells in patients with squamous cell carcinoma of the head and neck using a negative enrichment technology.

Jatana KR, Balasubramanian P, McMullen KP, Lang JC, Teknos TN, Chalmers JJ

Head Neck 38 1799-1803 12/01/2016
Circulating tumor cells in head and neck cancer: A review.

McMullen KP, Chalmers JJ, Jatana KR, Lang JC, Kumar P

World J Otorhinolaryngol Head Neck Surg 2 109-116 06/01/2016
Multiparameter Evaluation of the Heterogeneity of Circulating Tumor Cells Using Integrated RNA In Situ Hybridization and Immunocytochemical Analysis.

Wu Y, Park KJ, Deighan C, Amaya P, Miller B, Pan Q, Zborowski M, Lustberg M, Chalmers J

Front Oncol 6 234 01/01/2016
Gene expression patterns through oral squamous cell carcinoma development: PD-L1 expression in primary tumor and circulating tumor cells.

Oliveira-Costa JP, de Carvalho AF, da Silveira da GG, Amaya P, Wu Y, Park KJ, Gigliola MP, Lustberg M, Buim ME, Ferreira EN, Kowalski LP, Chalmers JJ, Soares FA, Carraro DM, Ribeiro-Silva A, Oliveira-Costa JP, de Carvalho AF, daSilveira GG, Amaya P, Wu Y, Park KJ, Gigliola MP, Lustberg M, Cavicchioli Buim ME, Ferreira EN, Kowalski LP, Chalmers JJ, Soares FA, Carraro DM, Ribeiro-Silva A, Oliveira-Costa JP, Carvalho AF, Silveira GG, Amaya P, Wu Y, Park KJ, Gigliola MP, Lustberg M, Buim ME, Ferreira EN, Kowalski LP, Chalmers JJ, Soares FA, Carraro DM, Ribeiro-Silva A

Oncotarget 6 20902-20 08/28/2015
Gene expression patterns through oral squamous cell carcinoma development: PD-L1 expression in primary tumor and circulating tumor cells.

Oliveira-Costa JP, de Carvalho AF, da Silveira da GG, Amaya P, Wu Y, Park KJ, Gigliola MP, Lustberg M, Buim ME, Ferreira EN, Kowalski LP, Chalmers JJ, Soares FA, Carraro DM, Ribeiro-Silva A, Oliveira-Costa JP, de Carvalho AF, daSilveira GG, Amaya P, Wu Y, Park KJ, Gigliola MP, Lustberg M, Cavicchioli Buim ME, Ferreira EN, Kowalski LP, Chalmers JJ, Soares FA, Carraro DM, Ribeiro-Silva A, Oliveira-Costa JP, Carvalho AF, Silveira GG, Amaya P, Wu Y, Park KJ, Gigliola MP, Lustberg M, Buim ME, Ferreira EN, Kowalski LP, Chalmers JJ, Soares FA, Carraro DM, Ribeiro-Silva A

Oncotarget 6 20902-20 08/28/2015
Gene expression patterns through oral squamous cell carcinoma development: PD-L1 expression in primary tumor and circulating tumor cells.

Oliveira-Costa JP, de Carvalho AF, da Silveira da GG, Amaya P, Wu Y, Park KJ, Gigliola MP, Lustberg M, Buim ME, Ferreira EN, Kowalski LP, Chalmers JJ, Soares FA, Carraro DM, Ribeiro-Silva A, Oliveira-Costa JP, de Carvalho AF, daSilveira GG, Amaya P, Wu Y, Park KJ, Gigliola MP, Lustberg M, Cavicchioli Buim ME, Ferreira EN, Kowalski LP, Chalmers JJ, Soares FA, Carraro DM, Ribeiro-Silva A, Oliveira-Costa JP, Carvalho AF, Silveira GG, Amaya P, Wu Y, Park KJ, Gigliola MP, Lustberg M, Buim ME, Ferreira EN, Kowalski LP, Chalmers JJ, Soares FA, Carraro DM, Ribeiro-Silva A

Oncotarget 6 20902-20 08/28/2015
CSF1-ETS2-induced microRNA in myeloid cells promote metastatic tumor growth.

Mathsyaraja H, Thies K, Taffany DA, Deighan C, Liu T, Yu L, Fernandez SA, Shapiro C, Otero J, Timmers C, Lustberg MB, Chalmers J, Leone G, Ostrowski MC

Oncogene 34 3651-61 07/01/2015
Magnetic separation of algae genetically modified for increased intracellular iron uptake.

Chalmers JJ, Buck A, Zborowski M, Lane CD, Kumar A, Moore LR, White N, Stroff C, Xue W

J Magn Magn Mater 380 201-204 04/15/2015
Tailoring the surface charge of dextran-based polymer coated SPIONs for modulated stem cell uptake and MRI contrast.

Barrow M, Taylor A, Nieves DJ, Bogart LK, Mandal P, Collins CM, Moore LR, Chalmers JJ, Lévy R, Williams SR, Murray P, Rosseinsky MJ, Adams DJ

Biomater Sci 3 608-16 04/01/2015
Feasibility study of red blood cell debulking by magnetic field-flow fractionation with step-programmed flow.

Moore LR, Williams PS, Nehl F, Abe K, Chalmers JJ, Zborowski M

Anal Bioanal Chem 406 1661-70 02/01/2014
Heterogeneous atypical cell populations are present in blood of metastatic breast cancer patients.

Lustberg MB, Balasubramanian P, Miller B, Garcia-Villa A, Deighan C, Wu Y, Carothers S, Berger M, Ramaswamy B, Macrae ER, Wesolowski R, Layman RM, Mrozek E, Pan X, Summers TA, Shapiro CL, Chalmers JJ

Breast Cancer Res 16 R23 01/01/2014
Isolation and analysis of rare cells in the blood of cancer patients using a negative depletion methodology.

Miller BL, Balasubramanian P, Lustberg MB, Zborowski M, Chalmers JJ, Wu Y, Deighan CJ

Methods 64 169-82 12/01/2013

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Jeffrey J Chalmers, PhD

College

Department/Division

Academic Title

Research Program

Research Interest

Education and Background

Office Location

Publications

Pharmacy informatics in multihospital health systems: Opportunities and challenges.

Implementing Liquid Biopsies in Clinical Trials: State of Affairs, Opportunities, and Challenges.

Continuous, intrinsic magnetic depletion of erythrocytes from whole blood with a quadrupole magnet and annular flow channel; pilot scale study.

Correlation of simulation/finite element analysis to the separation of intrinsically magnetic spores and red blood cells using a microfluidic magnetic deposition system.

Magnetic Quantum Dots Steer and Detach Microtubules from Kinesin-Coated Surfaces.

Mechanotransduction Effects on Endothelial Cell Proliferation via CD31 and VEGFR2: Implications for Immunomagnetic Separation.

Tessellated permanent magnet circuits for flow-through, open gradient separations of weakly magnetic materials.

Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells.

Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery.

Multispectral Imaging Analysis of Circulating Tumor Cells in Negatively Enriched Peripheral Blood Samples.

Effect of surgical intervention on circulating tumor cells in patients with squamous cell carcinoma of the head and neck using a negative enrichment technology.

Circulating tumor cells in head and neck cancer: A review.

Multiparameter Evaluation of the Heterogeneity of Circulating Tumor Cells Using Integrated RNA In Situ Hybridization and Immunocytochemical Analysis.

Gene expression patterns through oral squamous cell carcinoma development: PD-L1 expression in primary tumor and circulating tumor cells.

Gene expression patterns through oral squamous cell carcinoma development: PD-L1 expression in primary tumor and circulating tumor cells.

Gene expression patterns through oral squamous cell carcinoma development: PD-L1 expression in primary tumor and circulating tumor cells.

CSF1-ETS2-induced microRNA in myeloid cells promote metastatic tumor growth.

Magnetic separation of algae genetically modified for increased intracellular iron uptake.

Tailoring the surface charge of dextran-based polymer coated SPIONs for modulated stem cell uptake and MRI contrast.

Feasibility study of red blood cell debulking by magnetic field-flow fractionation with step-programmed flow.

Heterogeneous atypical cell populations are present in blood of metastatic breast cancer patients.

Isolation and analysis of rare cells in the blood of cancer patients using a negative depletion methodology.

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