Joelle M Fenger, DVM, PhD, ACVIM
College of Veterinary Medicine
Veterinary Clinical Sciences
As a veterinary oncologist, Dr. Fenger’s work using spontaneous models of cancer in dogs has focused on the comparative biology of canine and human cancers with the goal of identifying common molecular pathways that provide a foundation for translational clinical trials. Her lab previously identified miR-9 as a mediator of invasive behavior and metastasis in canine mast cell tumors and osteosarcoma; a similar role for miR-9 has been defined in metastatic human osteosarcoma. They are currently investigating signaling pathways altered by miR-9 that promote this phenotype and evaluating the impact that dysregulation of miR-9 and the tumor suppressor Wwox have in promoting osteosarcoma initiation/progression.