John Phay, MD

John Phay


College of Medicine



Academic Title

Assoc Professor - Clinical

Research Program

Molecular Biology and Cancer Genetics

Research Interest

Thyroid Cancer, Cancer, Adrenocortical Carcinoma, Multiple Endocrine Neoplasia Type 2a, Cushing Syndrome, Parathyroid Cancer, Hyperparathyroidism, Primary, Neuroendocrine Tumors, Multiple Endocrine Neoplasia Type 1, Multiple Endocrine Neoplasia Type 2b

Dr. Phay has two main research projects. The first is examining a novel AMPK activator for the treatment of thyroid cancer. Dr. Phay's research has shown in multiple human thyroid cancer cell lines that OSU-53 has inhibited growth at concentrations equal or lower than in breast cancer cells, and a dose and time-dependent activation of AMPK. He is currently studying the mechanism of action to potentially use synergistically with known BRAF inhibitors. The second research project is creating a molecular imaging agent for medullary thyroid cancer (MTC) and parathyroid tumors. The calcium sensing-receptor (CaSR) is expressed primarily on parathyroids, thyroid C-cells, and the kidney, as well as in MTC. Further development may allow pre-operative and intra-operative detection to improve surgical outcomes.

Education and Background


  • BA, Williams College

    Williamstown, MA (USA)

  • MD, University of California at San Francisco School of Medicine

    San Francisco, CA (USA)


  • Resident in General Surgery

    Washington University School of Medicine

    St. Louis, MO (USA)


  • Howard Hughes Research Fellowship

    University of California at San Francisco

    San Francisco, CA (USA)

  • Surgical Oncology Training Grant Fellowship

    Washington University School of Medicine

    St. Louis, MO (USA)

Office Location

N924 Doan Hall

410 W 10th Ave, Columbus, OH 43210




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