John Phay, MD

College

College of Medicine

Department/Division

Surgery

Academic Title

Assoc Professor - Clinical

Research Program

Molecular Biology and Cancer Genetics

Research Interest

Thyroid Cancer, Cancer, Adrenocortical Carcinoma, Multiple Endocrine Neoplasia Type 2a, Cushing Syndrome, Parathyroid Cancer, Hyperparathyroidism, Primary, Neuroendocrine Tumors, Multiple Endocrine Neoplasia Type 1, Multiple Endocrine Neoplasia Type 2b

Dr. Phay has two main research projects. The first is examining a novel AMPK activator for the treatment of thyroid cancer. Dr. Phay's research has shown in multiple human thyroid cancer cell lines that OSU-53 has inhibited growth at concentrations equal or lower than in breast cancer cells, and a dose and time-dependent activation of AMPK. He is currently studying the mechanism of action to potentially use synergistically with known BRAF inhibitors. The second research project is creating a molecular imaging agent for medullary thyroid cancer (MTC) and parathyroid tumors. The calcium sensing-receptor (CaSR) is expressed primarily on parathyroids, thyroid C-cells, and the kidney, as well as in MTC. Further development may allow pre-operative and intra-operative detection to improve surgical outcomes.

Education and Background

Education

BA, Williams College

Williamstown, MA (USA)
MD, University of California at San Francisco School of Medicine

San Francisco, CA (USA)
Fellowship, University of California at San Francisco

San Francisco, CA (USA)
Fellowship, Washington University School of Medicine

St. Louis, MO (USA)

Residencies

Resident in General Surgery

Washington University School of Medicine

St. Louis, MO (USA)

Fellowship

Howard Hughes Research Fellowship

University of California at San Francisco

San Francisco, CA (USA)
Surgical Oncology Training Grant Fellowship

Washington University School of Medicine

St. Louis, MO (USA)

Office Location

N924 Doan Hall

410 W 10th Ave, Columbus, OH 43210

614-293-8550

614-293-3465

phay.1@osu.edu;JOHN.PHAY@OSUMC.EDU

Publications

Developing a clinical prototype to guide surgeons for intraoperative label-free identification of parathyroid glands in real-time.

White LM, Solorzano CC, Mahadevan-Jansen A, Mannoh EA, Sanders ME, McWade MA, Phay JE, Broome JT, Baregamian N, Paras C, Thomas G

Thyroid in press 08/07/2018
Identification of the Thoracic Duct Using Indocyanine Green During Cervical Lymphadenectomy.

Skoracki R, Chakedis J, Terando AM, Phay JE, Shirley LA

Ann Surg Oncol in press 08/03/2018
Role of Additional Organ Resection in Adrenocortical Carcinoma: Analysis of 167 Patients from the U.S. Adrenocortical Carcinoma Database.

Shirley LA, Salem A, Sicklick J, Maithel SK, Jin L, Duh QY, Kiernan CM, Gad S, Phay J, Postlewait LM, Prescott J, Weber S, Marincola Smith P, Poultsides G, Pawlik T, Shenoy R, Tran TB, Wang TS, Fields RC, Mansour J, Seiser N, Votanopoulos K, Glenn J, Yopp A, Levine EA, Hatzaras I, Solórzano CC

Ann Surg Oncol in press 06/04/2018
The role of SMAD3 in the genetic predisposition to papillary thyroid carcinoma.

Phay JE, Shen R, Wang Y, Brock P, de la Chapelle A, He H, Li W, Liyanarachchi S, Genutis LK, Yu L

Genet Med in press 01/04/2018
A Novel T-Stage Classification System for Adrenocortical Carcinoma: Proposal from the US Adrenocortical Carcinoma Study Group.

Ethun CG, Tran TB, Keplinger K, Phay JE, Hatzaras I, Maithel SK, Salem A, Pawlik TM, Mansour JC, Postlewait LM, Weber SM, Gad S, Jin LX, Votanopoulos KI, Solórzano CC, Shenoy R, Staley CA, Wang TS, Sicklick JK, Yopp AC, Kiernan CM, Prescott JD, Glenn J, Poultsides GA, Seiser N, Poorman CE, Levine EA, Fields RC, Duh QY

Ann Surg Oncol in press 11/21/2017
The role of NRG1 in the predisposition to papillary thyroid carcinoma.

Li W, Brock P, Phay JE, Genutis LK, Shen R, de la Chapelle A, Wang Y, Yu L, He H, Maharry S, Liyanarachchi S

J Clin Endocrinol Metab in press 11/07/2017
Favorable and Durable Response to Pazopanib in Metastatic Refractory Paraganglioma.

Patel S, Owen D, Schmidt CR, Kirschner LS, Phay J, Shirley L, Dillhoff M, Brock P, Espinosa A, Shah MH, Konda B

J Oncol Pract in press 08/29/2017
Blood Transfusion and Survival for Resected Adrenocortical Carcinoma: A Study from the United States Adrenocortical Carcinoma Group.

Poorman CE, Postlewait LM, Ethun CG, Tran TB, Prescott JD, Pawlik TM, Wang TS, Glenn J, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Staley CA, Poultsides GA, Maithel SK

Am Surg 83 761-768 07/01/2017
Biological evaluation of a novel fluorescent-imaging agent for medullary thyroid cancer in an orthotopic model.

Rossfeld KK, Justiniano SE, Ding H, Gong L, Kothandaraman S, Sawant D, Saji M, Wright CL, Kirschner LS, Ringel MD, Tweedle MF, Phay JE

J Clin Endocrinol Metab 102(9) 268-77 06/07/2017
Minimally Invasive Resection of Adrenocortical Carcinoma: a Multi-Institutional Study of 201 Patients.

Lee CW, Md AI, Schneider DF, Leverson GE, Tran TB, Poultsides GA, Postlewait LM, Maithel SK, Wang TS, Hatzaras I, Shenoy R, Phay JE, Shirley L, Fields RC, Jin LX, Pawlik TM, Prescott JD, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Weber SM, Lee CW, Salem AI, Schneider DF, Leverson GE, Tran TB, Poultsides GA, Postlewait LM, Maithel SK, Wang TS, Hatzaras I, Shenoy R, Phay JE, Shirley L, Fields RC, Jin LX, Pawlik TM, Prescott JD, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Weber SM

J Gastrointest Surg 21 352-362 02/01/2017
Minimally Invasive Resection of Adrenocortical Carcinoma: a Multi-Institutional Study of 201 Patients.

Lee CW, Md AI, Schneider DF, Leverson GE, Tran TB, Poultsides GA, Postlewait LM, Maithel SK, Wang TS, Hatzaras I, Shenoy R, Phay JE, Shirley L, Fields RC, Jin LX, Pawlik TM, Prescott JD, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Weber SM, Lee CW, Salem AI, Schneider DF, Leverson GE, Tran TB, Poultsides GA, Postlewait LM, Maithel SK, Wang TS, Hatzaras I, Shenoy R, Phay JE, Shirley L, Fields RC, Jin LX, Pawlik TM, Prescott JD, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Weber SM

J Gastrointest Surg 21 352-362 02/01/2017
MYH9 binds to lncRNA gene PTCSC2 and regulates FOXE1 in the 9q22 thyroid cancer risk locus.

Wang Y, He H, Li W, Phay J, Shen R, Yu L, Hancioglu B, de la Chapelle A

Proc Natl Acad Sci U S A 114 474-479 01/17/2017
Curative Surgical Resection of Adrenocortical Carcinoma: Determining Long-term Outcome Based on Conditional Disease-free Probability.

Kim Y, Margonis GA, Prescott JD, Tran TB, Postlewait LM, Maithel SK, Wang TS, Glenn JA, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Poultsides GA, Pawlik TM

Ann Surg 265 197-204 01/01/2017
The Role of Central Neck Lymph Node Dissection in the Management of Papillary Thyroid Cancer.

Shirley LA, Jones NB, Phay JE

Front Oncol 7 122 01/01/2017
Lymphadenectomy for Adrenocortical Carcinoma: Is There a Therapeutic Benefit?

Gerry JM, Tran TB, Postlewait LM, Maithel SK, Prescott JD, Wang TS, Glenn JA, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Hatzaras I, Shenoy R, Pawlik TM, Norton JA, Poultsides GA

Ann Surg Oncol 23 708-713 12/01/2016
Clinical Score Predicting Long-Term Survival after Repeat Resection for Recurrent Adrenocortical Carcinoma.

Tran TB, Maithel SK, Pawlik TM, Wang TS, Hatzaras I, Phay JE, Fields RC, Weber SM, Sicklick JK, Yopp AC, Duh QY, Solorzano CC, Votanopoulos KI, Poultsides GA

J Am Coll Surg 223 794-803 12/01/2016
Actual 10-year survivors following resection of adrenocortical carcinoma.

Tran TB, Postlewait LM, Maithel SK, Prescott JD, Wang TS, Glenn J, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Hatzaras I, Shenoy R, Pawlik TM, Norton JA, Poultsides GA

J Surg Oncol 114 971-976 12/01/2016
Primary Cell Culture Systems for Human Thyroid Studies.

Wang Y, Li W, Phay JE, Shen R, Pellegata N, Saji M, Ringel MD, de la Chapelle A, He H, Wang Y, Li W, Phay JE, Shen R, Pellegata NS, Saji M, Ringel MD, de la Chapelle A, He H

Thyroid 26 1131-40 08/01/2016
Primary Cell Culture Systems for Human Thyroid Studies.

Wang Y, Li W, Phay JE, Shen R, Pellegata N, Saji M, Ringel MD, de la Chapelle A, He H, Wang Y, Li W, Phay JE, Shen R, Pellegata NS, Saji M, Ringel MD, de la Chapelle A, He H

Thyroid 26 1131-40 08/01/2016
Outcomes after resection of cortisol-secreting adrenocortical carcinoma.

Margonis GA, Kim Y, Tran TB, Postlewait LM, Maithel SK, Wang TS, Glenn JA, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Poultsides GA, Pawlik TM

Am J Surg 211 1106-13 06/01/2016
Outcomes of Adjuvant Mitotane after Resection of Adrenocortical Carcinoma: A 13-Institution Study by the US Adrenocortical Carcinoma Group.

Postlewait LM, Ethun CG, Tran TB, Prescott JD, Pawlik TM, Wang TS, Glenn J, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Staley CA, Poultsides GA, Maithel SK

J Am Coll Surg 222 480-90 04/01/2016
Nomograms to Predict Recurrence-Free and Overall Survival After Curative Resection of Adrenocortical Carcinoma.

Kim Y, Margonis GA, Prescott JD, Tran TB, Postlewait LM, Maithel SK, Wang TS, Evans DB, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem AI, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Poultsides GA, Pawlik TM

JAMA Surg 151 365-73 04/01/2016
Incidence of Perioperative Complications Following Resection of Adrenocortical Carcinoma and Its Association with Long-Term Survival.

Margonis GA, Amini N, Kim Y, Tran TB, Postlewait LM, Maithel SK, Wang TS, Evans DB, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Moses LE, Weber SM, Salem A, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Poultsides GA, Pawlik TM

World J Surg 40 706-714 03/01/2016
Targeting myeloid-derived suppressor cells using a novel adenosine monophosphate-activated protein kinase (AMPK) activator.

Trikha P, Plews RL, Stiff A, Gautam S, Hsu V, Abood D, Wesolowski R, Landi I, Mo X, Phay J, Chen CS, Byrd J, Caligiuri M, Tridandapani S, Carson W

Oncoimmunology 5 e1214787 01/01/2016
Curative Resection of Adrenocortical Carcinoma: Rates and Patterns of Postoperative Recurrence.

Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Poultsides GA, Pawlik TM, Amini N, Margonis GA, Kim Y, Tran TB, Postlewait LM, Maithel SK, Wang TS, Evans DB, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick JK, Gad S, Yopp AC

Ann Surg Oncol 23 126-33 01/01/2016
Adrenocortical Carcinoma: Impact of Surgical Margin Status on Long-Term Outcomes.

Margonis GA, Kim Y, Prescott JD, Tran TB, Postlewait LM, Maithel SK, Wang TS, Evans DB, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Poultsides GA, Pawlik TM

Ann Surg Oncol 23 134-41 01/01/2016
Integrin-linked kinase affects signaling pathways and migration in thyroid cancer cells and is a potential therapeutic target.

Shirley LA, McCarty S, Yang MC, Saji M, Zhang X, Phay J, Ringel MD, Chen CS

Surgery 159 163-70 01/01/2016
Curative Surgical Resection of Adrenocortical Carcinoma: Determining Long-term Outcome Based on Conditional Disease-free Probability.

Kim Y, Margonis GA, Prescott JD, Tran TB, Postlewait LM, Maithel SK, Wang TS, Glenn JA, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Poultsides GA, Pawlik TM

Ann Surg in press 12/29/2015
Incidence and Risk Factors Associated with Readmission After Surgical Treatment for Adrenocortical Carcinoma.

Valero-Elizondo J, Kim Y, Prescott JD, Margonis GA, Tran TB, Postlewait LM, Maithel SK, Wang TS, Glenn JA, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Poultsides GA, Pawlik TM

J Gastrointest Surg 19 2154-61 12/01/2015
Neutrophil-lymphocyte and platelet-lymphocyte ratio as predictors of disease specific survival after resection of adrenocortical carcinoma.

Bagante F, Tran TB, Postlewait LM, Maithel SK, Wang TS, Evans DB, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Poultsides GA, Pawlik TM

J Surg Oncol 112 164-72 08/01/2015
Multiple functional variants in long-range enhancer elements contribute to the risk of SNP rs965513 in thyroid cancer.

He H, Li W, Liyanarachchi S, Srinivas M, Wang Y, Akagi K, Wang Y, Wu D, Wang Q, Jin V, Symer DE, Shen R, Phay J, Nagy R, de la Chapelle A

Proc Natl Acad Sci U S A 112 6128-33 05/12/2015
A novel dual AMPK activator/mTOR inhibitor inhibits thyroid cancer cell growth.

Plews RL, Mohd Yusof A, Wang C, Saji M, Zhang X, Chen CS, Ringel MD, Phay JE

J Clin Endocrinol Metab 100 E748-56 05/01/2015
Visual vignette.

Nabhan F, Tang B, Carrau R, Prevedello D, Phay J, Nabhan F, Tang B, Carrau RL, Prevedello DM, Phay J

Endocr Pract 21 454 04/01/2015
Visual vignette.

Nabhan F, Tang B, Carrau R, Prevedello D, Phay J, Nabhan F, Tang B, Carrau RL, Prevedello DM, Phay J

Endocr Pract 21 454 04/01/2015
Intraoperative scintigraphy using a large field-of-view portable gamma camera for primary hyperparathyroidism: initial experience.

Hall NC, Plews RL, Agrawal A, Povoski SP, Wright CL, Zhang J, Martin EW, Phay J, Hall NC, Plews RL, Agrawal A, Povoski SP, Wright CL, Zhang J, Martin EW Jr, Phay J

Biomed Res Int 2015 930575 01/01/2015
Intraoperative scintigraphy using a large field-of-view portable gamma camera for primary hyperparathyroidism: initial experience.

Hall NC, Plews RL, Agrawal A, Povoski SP, Wright CL, Zhang J, Martin EW, Phay J, Hall NC, Plews RL, Agrawal A, Povoski SP, Wright CL, Zhang J, Martin EW Jr, Phay J

Biomed Res Int 2015 930575 01/01/2015
Label-free intraoperative parathyroid localization with near-infrared autofluorescence imaging.

McWade MA, Paras C, White LM, Phay JE, Solórzano CC, Broome JT, Mahadevan-Jansen A

J Clin Endocrinol Metab 99 4574-80 12/01/2014
Occult primary, version 3.2014.

Ettinger DS, Handorf CR, Agulnik M, Bowles DW, Cates JM, Cristea M, Dotan E, Eaton KD, Fidias PM, Gierada D, Gilcrease GW, Godby K, Iyer R, Lenzi R, Phay J, Rashid A, Saltz L, Schwab RB, Shulman LN, Smerage JB, Stevenson MM, Varadhachary GR, Zager JS, Zhen WK, Bergman MA, Freedman-Cass DA

J Natl Compr Canc Netw 12 969-74 07/01/2014
Metastatic mechanisms in follicular cell-derived thyroid cancer.

Phay JE, Ringel MD

Endocr Relat Cancer 20 R307-19 12/01/2013
Development of a calcium-sensing receptor molecular imaging agent.

Yusof AM, Kothandaraman S, Zhang X, Saji M, Ringel MD, Tweedle MF, Phay JE

Surgery 154 1378-84; discussion 1384 12/01/2013
A novel optical approach to intraoperative detection of parathyroid glands.

McWade MA, Paras C, White LM, Phay JE, Mahadevan-Jansen A, Broome JT

Surgery 154 1371-7; discussion 1377 12/01/2013
Localization of CaSR antagonists in CaSR-expressing medullary thyroid cancer.

Ding H, Yusof AM, Kothandaraman S, Saji M, Wang C, Kumar K, Milum K, Carleton M, Pan X, Ringel MD, Tweedle MF, Phay JE

J Clin Endocrinol Metab 98 E1722-9 11/01/2013