Jon P Butchar, PhD
College of Medicine
Res Asst Professor
Infection, Leukemia, Lymphocytic, Chronic, B-Cell, tularemia, Cancer
Monocytes / macrophages can engulf or even directly kill antibody-coated tumor cells, and this is mediated largely through Fc-gamma receptors. These cells can also respond to pathogens such as bacteria or viruses by activation of Toll-like receptors. Such Toll-like receptor activation has been shown to enhance Fc-gamma receptor function. My work involves bringing pathogenesis and tumor immunotherapy together by studying the interactions between Fc-gamma receptor and Toll-like receptor signaling. The ultimate goal is to help improve the efficacy of antibody therapy.