Kevin R Coombes, PhD
College of Medicine
Kevin Coombes, PhD, brings a mathematical perspective to the Translational Therapeutics team at the OSUCCC – James. His research centers on statistical, mathematical and computational methods to process, analyze and understand highly multivariate biological data from high-throughput technologies.He is especially interested in methods that incorporate existing biological knowledge early in the analytical process, and in methods that integrate diverse types of biological data toward predicting clinically relevant patient outcomes. More than 140 articles that he wrote or co-authored have been published in dozens of well-respected publications, including Journal of the National Cancer Institute, Journal of Thoracic Oncology and Clinical Cancer Research. Topics of recently co-authored articles include exploration of patterns of CTCF and ZFHX3 mutation and associated outcomes in endometrial cancer, as well as how a patient-derived, pan-cancer EMT signature identifies global molecular alterations and immune-target enrichment following epithelial-to-mesenchymal transition. Dr. Coombes has been an investigator in significant research, serving as co-investigator for projects such as personalizing mouse stem cell-like cell therapy through exploitation of KRAS-activated pathways, and protein-coding and non-coding RNA biomarkers for early detection of chronic lymphocytic leukemia. He has shared his research in more than three dozen presentations to organizations such as the International Conference on Bioinformatics, American Chemical Society Biochips Conference and American Association of Clinical Chemistry.