Lawrence S Kirschner, MD, PhD
College of Medicine
Molecular Biology and Cancer Genetics
Cancer, Carney Complex, Hyperplasia, Thyroid Cancer, Myxoma, Adrenocortical Carcinoma, Pituitary Cancer, Neurilemmoma, Loss of Heterozygosity, Cushing Syndrome
Dr. Kirschner's research is focused on endocrine tumor genetics, with specific interest in understanding how dysregulation of PKA contributes to tumorigenesis in cAMP-responsive tissues. Using a combination of in vivo mouse models and in vitro tissue culture work, his lab aims to understand how activated PKA cross-talks with a variety of other signaling pathways to produce tumors. As part of OSU’s thyroid cancer group, they have developed mouse models of benign and malignant follicular thyroid tumors which behave similarly to the human disease.