Lei Cao, PhD

College

College of Medicine

Department/Division

Cancer Biology and Genetics

Academic Title

Assoc Professor

Research Program

Molecular Biology and Cancer Genetics

Research Interest

Cancer, Obesity, Wounds and Injuries, Melanoma, Weight Loss

Lei Cao, PhD, is a member of the Molecular Biology and Cancer Genetics Program at the OSUCCC – James.

Dr. Cao’s research has characterized a novel brain-fat axis underlying the antiobesity and anticancer phenotypes involved in a complex environment. She is using multidisciplinary approaches to further define this axis and identify molecular mediators.

Her work in this area also is designed to foster genetic and pharmacological approaches to combat obesity, metabolic syndromes and cancer.

Dr. Cao has authored or co-authored numerous articles appearing in well-known publications such as Cell, Nature Medicine, Nature Genetics and Cell Metabolism.

Education and Background

Office Location

910 Biomedical Research Tower

460 W 12th Ave, Columbus, OH 43210

614-366-5679

614-292-6356

cao.76@osu.edu

Publications

Intermittent ? burst stimulation modulates resting-state functional connectivity in the attention network and promotes behavioral recovery in patients with visual spatial neglect.

Cao L, Fu W, Zhang Y, Huo S, Du J, Zhu L, Song W

Neuroreport 27 1261-1265 12/07/2016
Olig2-Targeted G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Survival in Response to Lysolecithin-Induced Demyelination.

Ou Z, Sun Y, Lin L, You N, Liu X, Li H, Ma Y, Cao L, Han Y, Liu M, Deng Y, Yao L, Lu QR, Chen Y

J Neurosci 36 10560-10573 10/12/2016
Laparoscopic Surgery Can Reduce Postoperative Edema Compared with Open Surgery.

Guo D, Gong J, Cao L, Wei Y, Guo Z, Zhu W

Gastroenterol Res Pract 2016 5264089 01/01/2016
Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype.

Xiao R, Bergin SM, Huang W, Slater AM, Liu X, Judd RT, Lin ED, Widstrom KJ, Scoville SD, Yu J, Caligiuri M, Cao L, Xiao R, Bergin SM, Huang W, Slater AM, Liu X, Judd RT, Lin ED, Widstrom KJ, Scoville SD, Yu J, Caligiuri MA, Cao L, Xiao R, Bergin SM, Huang W, Slater AM, Liu X, Judd RT, Lin ED, Widstrom KJ, Scoville SD, Yu J, Caligiuri MA, Cao L, Xiao R, Bergin SM, Huang W, Slater AM, Liu X, Judd RT, Lin EJ, Widstrom KJ, Scoville SD, Yu J, Caligiuri MA, Cao L

Cancer Immunol Res 4 488-497 01/01/2016
Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype.

Xiao R, Bergin SM, Huang W, Slater AM, Liu X, Judd RT, Lin ED, Widstrom KJ, Scoville SD, Yu J, Caligiuri M, Cao L, Xiao R, Bergin SM, Huang W, Slater AM, Liu X, Judd RT, Lin ED, Widstrom KJ, Scoville SD, Yu J, Caligiuri MA, Cao L, Xiao R, Bergin SM, Huang W, Slater AM, Liu X, Judd RT, Lin ED, Widstrom KJ, Scoville SD, Yu J, Caligiuri MA, Cao L, Xiao R, Bergin SM, Huang W, Slater AM, Liu X, Judd RT, Lin EJ, Widstrom KJ, Scoville SD, Yu J, Caligiuri MA, Cao L

Cancer Immunol Res 4 488-497 01/01/2016
Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype.

Xiao R, Bergin SM, Huang W, Slater AM, Liu X, Judd RT, Lin ED, Widstrom KJ, Scoville SD, Yu J, Caligiuri M, Cao L, Xiao R, Bergin SM, Huang W, Slater AM, Liu X, Judd RT, Lin ED, Widstrom KJ, Scoville SD, Yu J, Caligiuri MA, Cao L, Xiao R, Bergin SM, Huang W, Slater AM, Liu X, Judd RT, Lin ED, Widstrom KJ, Scoville SD, Yu J, Caligiuri MA, Cao L, Xiao R, Bergin SM, Huang W, Slater AM, Liu X, Judd RT, Lin EJ, Widstrom KJ, Scoville SD, Yu J, Caligiuri MA, Cao L

Cancer Immunol Res 4 488-497 01/01/2016
Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype.

Xiao R, Bergin SM, Huang W, Slater AM, Liu X, Judd RT, Lin ED, Widstrom KJ, Scoville SD, Yu J, Caligiuri M, Cao L, Xiao R, Bergin SM, Huang W, Slater AM, Liu X, Judd RT, Lin ED, Widstrom KJ, Scoville SD, Yu J, Caligiuri MA, Cao L, Xiao R, Bergin SM, Huang W, Slater AM, Liu X, Judd RT, Lin ED, Widstrom KJ, Scoville SD, Yu J, Caligiuri MA, Cao L, Xiao R, Bergin SM, Huang W, Slater AM, Liu X, Judd RT, Lin EJ, Widstrom KJ, Scoville SD, Yu J, Caligiuri MA, Cao L

Cancer Immunol Res 4 488-497 01/01/2016
A Protocol for Housing Mice in an Enriched Environment.

Slater AM, Cao L

J Vis Exp e52874 06/08/2015
Adipose VEGF Links the White-to-Brown Fat Switch With Environmental, Genetic, and Pharmacological Stimuli in Male Mice.

During MJ, Liu X, Huang W, Magee D, Slater A, McMurphy T, Wang C, Cao L

Endocrinology 156 2059-73 06/01/2015
Hypothalamic gene transfer of BDNF inhibits breast cancer progression and metastasis in middle age obese mice.

Liu X, McMurphy T, Xiao R, Slater A, Huang W, Cao L

Mol Ther 22 1275-84 07/01/2014
Adipose tissue insulin receptor knockdown via a new primate-derived hybrid recombinant AAV serotype.

Liu X, Magee D, Wang C, McMurphy T, Slater A, During M, Cao L

Mol Ther Methods Clin Dev 1 02/05/2014
The anti-tumor activity of a neutralizing nanobody targeting leptin receptor in a mouse model of melanoma.

McMurphy T, Xiao R, Magee D, Slater A, Zabeau L, Tavernier J, Cao L

PLoS One 9 e89895 01/01/2014

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Lei Cao, PhD

College

Department/Division

Academic Title

Research Program

Research Interest

Education and Background

Office Location

Publications

Intermittent ? burst stimulation modulates resting-state functional connectivity in the attention network and promotes behavioral recovery in patients with visual spatial neglect.

Olig2-Targeted G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Survival in Response to Lysolecithin-Induced Demyelination.

Laparoscopic Surgery Can Reduce Postoperative Edema Compared with Open Surgery.

Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype.

Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype.

Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype.

Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype.

A Protocol for Housing Mice in an Enriched Environment.

Adipose VEGF Links the White-to-Brown Fat Switch With Environmental, Genetic, and Pharmacological Stimuli in Male Mice.

Hypothalamic gene transfer of BDNF inhibits breast cancer progression and metastasis in middle age obese mice.

Adipose tissue insulin receptor knockdown via a new primate-derived hybrid recombinant AAV serotype.

The anti-tumor activity of a neutralizing nanobody targeting leptin receptor in a mouse model of melanoma.

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