Lei Cao, PhD

College

College of Medicine

Department/Division

Cancer Biology and Genetics

Academic Title

Assoc Professor

Research Program

Molecular Biology and Cancer Genetics

Research Interest

>Cancer ● Obesity ● Wounds and Injuries ● Melanoma ● Weight Loss

Lei Cao, PhD, is a member of the Molecular Biology and Cancer Genetics Program at the OSUCCC – James.

Dr. Cao’s research has characterized a novel brain-fat axis underlying the antiobesity and anticancer phenotypes involved in a complex environment. She is using multidisciplinary approaches to further define this axis and identify molecular mediators.

Her work in this area also is designed to foster genetic and pharmacological approaches to combat obesity, metabolic syndromes and cancer.

Dr. Cao has authored or co-authored numerous articles appearing in well-known publications such as Cell, Nature Medicine, Nature Genetics and Cell Metabolism.

Office Location

910 Biomedical Research Tower

460 W 12th Ave, Columbus, OH 43210

614-366-5679

614-292-6356

cao.76@osu.edu;LEI.CAO@OSUMC.EDU

Publications

Enriched environment inhibits breast cancer progression in obese models with intact leptin signaling.

Foglesong G, Queen N, Huang W, Widstrom K, Cao L

Endocr Relat Cancer in press 03/01/2019
Adipocytes: A Novel Target for IL-15/IL-15Rα Cancer Gene Therapy.

Xiao R, Mansour AG, Huang W, Chrislip LA, Wilkins RK, Queen NJ, Youssef Y, Mao HC, Caligiuri MA, Cao L

Mol Ther in press 02/16/2019
Chi3l3 induces oligodendrogenesis in an experimental model of autoimmune neuroinflammation.

Starossom SC, Campo Garcia J, Woelfle T, Romero-Suarez S, Olah M, Watanabe F, Cao L, Yeste A, Tukker JJ, Quintana FJ, Imitola J, Witzel F, Schmitz D, Morkel M, Paul F, Infante-Duarte C, Khoury SJ

Nat Commun 10 217 01/15/2019
rAAV-Mediated Gene Delivery to Adipose Tissue.

Huang W, Queen NJ, Cao L

Methods Mol Biol 1950 389-405 01/01/2019
Enriched environment regulates thymocyte development and alleviates experimental autoimmune encephalomyelitis in mice.

Xiao R, Bergin SM, Huang W, Mansour AG, Liu X, Judd RT, Widstrom KJ, Queen NJ, Wilkins RK, Siu JJ, Ali S, Caligiuri MA, Cao L

Brain Behav Immun 75 137-148 01/01/2019
Intermittent θ burst stimulation modulates resting-state functional connectivity in the attention network and promotes behavioral recovery in patients with visual spatial neglect.

Cao L, Fu W, Zhang Y, Huo S, Du J, Zhu L, Song W

Neuroreport 27 1261-1265 12/07/2016
Olig2-Targeted G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Survival in Response to Lysolecithin-Induced Demyelination.

Ou Z, Sun Y, Lin L, You N, Liu X, Li H, Ma Y, Cao L, Han Y, Liu M, Deng Y, Yao L, Lu QR, Chen Y

J Neurosci 36 10560-10573 01/12/2016
Laparoscopic Surgery Can Reduce Postoperative Edema Compared with Open Surgery.

Guo D, Gong J, Cao L, Wei Y, Guo Z, Zhu W

Gastroenterol Res Pract 2016 5264089 01/01/2016
Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype.

Xiao R, Bergin SM, Huang W, Slater AM, Liu X, Judd RT, Lin ED, Widstrom KJ, Scoville SD, Yu J, Caligiuri MA, Cao L

Cancer Immunol Res 4 488-497 01/01/2016
Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype.

Xiao R, Bergin SM, Huang W, Slater AM, Liu X, Judd RT, Lin ED, Widstrom KJ, Scoville SD, Yu J, Caligiuri MA, Cao L

Cancer Immunol Res 4 488-497 01/01/2016
Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype.

Xiao R, Bergin SM, Huang W, Slater AM, Liu X, Judd RT, Lin ED, Widstrom KJ, Scoville SD, Yu J, Caligiuri MA, Cao L

Cancer Immunol Res 4 488-497 01/01/2016
Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype.

Xiao R, Bergin SM, Huang W, Slater AM, Liu X, Judd RT, Lin ED, Widstrom KJ, Scoville SD, Yu J, Caligiuri MA, Cao L

Cancer Immunol Res 4 488-497 01/01/2016
A Protocol for Housing Mice in an Enriched Environment.

Slater AM, Cao L

J Vis Exp e52874 06/08/2015
Adipose VEGF Links the White-to-Brown Fat Switch With Environmental, Genetic, and Pharmacological Stimuli in Male Mice.

During MJ, Liu X, Huang W, Magee D, Slater A, McMurphy T, Wang C, Cao L

Endocrinology 156 2059-73 06/01/2015
Hypothalamic gene transfer of BDNF inhibits breast cancer progression and metastasis in middle age obese mice.

Liu X, McMurphy T, Xiao R, Slater A, Huang W, Cao L

Mol Ther 22 1275-84 07/01/2014

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Lei Cao, PhD

College

Department/Division

Academic Title

Research Program

Research Interest

Office Location

Publications

Enriched environment inhibits breast cancer progression in obese models with intact leptin signaling.

Adipocytes: A Novel Target for IL-15/IL-15Rα Cancer Gene Therapy.

Chi3l3 induces oligodendrogenesis in an experimental model of autoimmune neuroinflammation.

rAAV-Mediated Gene Delivery to Adipose Tissue.

Enriched environment regulates thymocyte development and alleviates experimental autoimmune encephalomyelitis in mice.

Intermittent θ burst stimulation modulates resting-state functional connectivity in the attention network and promotes behavioral recovery in patients with visual spatial neglect.

Olig2-Targeted G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Survival in Response to Lysolecithin-Induced Demyelination.

Laparoscopic Surgery Can Reduce Postoperative Edema Compared with Open Surgery.

Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype.

Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype.

Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype.

Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype.

A Protocol for Housing Mice in an Enriched Environment.

Adipose VEGF Links the White-to-Brown Fat Switch With Environmental, Genetic, and Pharmacological Stimuli in Male Mice.

Hypothalamic gene transfer of BDNF inhibits breast cancer progression and metastasis in middle age obese mice.

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