Maria Mihaylova, PhD

Dr. Mihaylova is interested in understanding the effects of diet and aging on cellular metabolism. It is now appreciated that organismal and cellular metabolism can become deregulated with age, which can potentially accelerate cancer initiation or progression. One area of focus in her lab is understanding how metabolic deregulation in the gastrointestinal tract and liver can augment tissue homeostasis and promote age related pathologies, including cancer. They will employ a number of genetic and multidisciplinary analytical approaches, in both mouse models and 3D organoid culture systems, with the ultimate goal of translating metabolic liabilities into potential therapeutics.