Mark D Wewers, MD

College

College of Medicine

Department/Division

Internal Medicine

Academic Title

Professor

Research Program

Molecular Carcinogenesis and Chemoprevention

Research Interest

>Infection ● Sepsis ● Inflammation ● Emphysema ● Multiple Organ Failure ● tularemia

Mark Wewers, MD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where his research focuses on host defense against pathogens.

In particular, he seeks to understand how the lung and circulating mononuclear phagocytes sense danger from pathogens and respond with robust inflammation around IL-1.

His recent studies address the important role of the inflammasome adaptor ASC as a contributor to lung airway inflammation as well as the regulation of the pyroptosis generating inflammasome mediator, gasdermin D, as a factor in lung cell survival.

Dr. Wewers has co-authored many articles in well-respected publications, including Nature Immunology, Journal of Immunology, Journal of Biological Chemistry and Cell Reports.

Office Location

201 Davis Heart & Lung Research Inst

473 W 12th Ave, Columbus, OH 43210

614-247-7707

614-293-4799

wewers.2@osu.edu;MARK.WEWERS@OSUMC.EDU

Publications

The human lung mucosa drives differential Mycobacterium tuberculosis infection outcome in the alveolar epithelium.

Scordo JM, Olmo-Fontánez AM, Kelley HV, Sidiki S, Arcos J, Akhter A, Wewers MD, Torrelles JB

Mucosal Immunol in press 03/07/2019
Electronic vs Combustible Cigarette Effects on Inflammasome Component Release into Human Lung.

Tsai M, Song MA, McAndrew C, Brasky TM, Freudenheim JL, Mathé E, McElroy J, Reisinger SA, Shields PG, Wewers MD

Am J Respir Crit Care Med in press 01/04/2019
Electronic Cigarettes and the Lung Proteome.

Shields PG, Song MA, Freudenheim JL, Brasky TM, Mathe E, McElroy JP, Hummon AB, Wewers MD

Am J Respir Crit Care Med 198 1350-1351 11/15/2018
Microparticulate Caspase 1 Regulates Gasdermin D and Pulmonary Vascular Endothelial Cell Injury.

Mitra S, Exline M, Habyarimana F, Gavrilin MA, Baker PJ, Masters SL, Wewers MD, Sarkar A

Am J Respir Cell Mol Biol 59 56-64 01/01/2018
Exposure to human alveolar lining fluid enhances Mycobacterium bovis BCG vaccine efficacy against Mycobacterium tuberculosis infection in a CD8+ T-cell-dependent manner.

Moliva JI, Hossfeld AP, Canan CH, Dwivedi V, Wewers MD, Beamer G, Turner J, Torrelles JB

Mucosal Immunol 11 968-978 01/01/2018
Complement Receptor 3-Mediated Inhibition of Inflammasome Priming by Ras GTPase-Activating Protein During Francisella tularensis Phagocytosis by Human Mononuclear Phagocytes.

Hoang KV, Rajaram MVS, Curry HM, Gavrilin MA, Wewers MD, Schlesinger LS

Front Immunol 9 561 01/01/2018
Francisella induced microparticulate caspase-1/gasdermin-D activation is regulated by NLRP3 independent of Pyrin.

Mitra S, Dolvin E, Krishnamurthy K, Wewers MD, Sarkar A

PLoS One 13 e0209931 01/01/2018
The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation.

Ratner D, Orning MP, Proulx MK, Wang D, Gavrilin MA, Wewers MD, Alnemri ES, Johnson PF, Lee B, Mecsas J, Kayagaki N, Goguen JD, Lien E

PLoS Pathog 12 e1006035 12/01/2016
T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis.

Martin BN, Wang C, Zhang CJ, Kang Z, Gulen MF, Zepp JA, Zhao J, Bian G, Do JS, Min B, Pavicic PG Jr, El-Sanadi C, Fox PL, Akitsu A, Iwakura Y, Sarkar A, Wewers MD, Kaiser WJ, Mocarski ES, Rothenberg ME, Hise AG, Dubyak GR, Ransohoff RM, Li X

Nat Immunol 17 583-92 05/01/2016
Ethanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation.

Hoyt LR, Ather JL, Randall MJ, DePuccio DP, Landry CC, Wewers MD, Gavrilin MA, Poynter ME

J Immunol 197 1322-34 01/15/2016
Blood-Borne Lipopolysaccharide Is Rapidly Eliminated by Liver Sinusoidal Endothelial Cells via High-Density Lipoprotein.

Yao Z, Mates JM, Cheplowitz AM, Hammer LP, Maiseyeu A, Phillips GS, Wewers MD, Rajaram MV, Robinson JM, Anderson CL, Ganesan LP

J Immunol 197 2390-9 01/15/2016
IκBζ Regulates Human Monocyte Pro-Inflammatory Responses Induced by Streptococcus pneumoniae.

Sundaram K, Rahman MA, Mitra S, Knoell DL, Woodiga SA, King SJ, Wewers MD

PLoS One 11 e0161931 01/01/2016
Supernatants from stored red blood cell (RBC) units, but not RBC-derived microvesicles, suppress monocyte function in vitro.

Muszynski JA, Bale J, Nateri J, Nicol K, Wang Y, Wright V, Marsh CB, Gavrilin MA, Sarkar A, Wewers MD, Hall MW

Transfusion 55 1937-45 08/01/2015
Alpha 1-antitrypsin does not inhibit human monocyte caspase-1.

Rahman MA, Mitra S, Sarkar A, Wewers MD

PLoS One 10 e0117330 01/01/2015
Mononuclear Phagocyte-Derived Microparticulate Caspase-1 Induces Pulmonary Vascular Endothelial Cell Injury.

Mitra S, Wewers MD, Sarkar A

PLoS One 10 e0145607 01/01/2015
Monocyte Caspase-1 Is Released in a Stable, Active High Molecular Weight Complex Distinct from the Unstable Cell Lysate-Activated Caspase-1.

Shamaa OR, Mitra S, Gavrilin MA, Wewers MD

PLoS One 10 e0142203 01/01/2015

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Mark D Wewers, MD

College

Department/Division

Academic Title

Research Program

Research Interest

Office Location

Publications

The human lung mucosa drives differential Mycobacterium tuberculosis infection outcome in the alveolar epithelium.

Electronic vs Combustible Cigarette Effects on Inflammasome Component Release into Human Lung.

Electronic Cigarettes and the Lung Proteome.

Microparticulate Caspase 1 Regulates Gasdermin D and Pulmonary Vascular Endothelial Cell Injury.

Exposure to human alveolar lining fluid enhances Mycobacterium bovis BCG vaccine efficacy against Mycobacterium tuberculosis infection in a CD8+ T-cell-dependent manner.

Complement Receptor 3-Mediated Inhibition of Inflammasome Priming by Ras GTPase-Activating Protein During Francisella tularensis Phagocytosis by Human Mononuclear Phagocytes.

Francisella induced microparticulate caspase-1/gasdermin-D activation is regulated by NLRP3 independent of Pyrin.

The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation.

T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis.

Ethanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation.

Blood-Borne Lipopolysaccharide Is Rapidly Eliminated by Liver Sinusoidal Endothelial Cells via High-Density Lipoprotein.

IκBζ Regulates Human Monocyte Pro-Inflammatory Responses Induced by Streptococcus pneumoniae.

Supernatants from stored red blood cell (RBC) units, but not RBC-derived microvesicles, suppress monocyte function in vitro.

Alpha 1-antitrypsin does not inhibit human monocyte caspase-1.

Mononuclear Phagocyte-Derived Microparticulate Caspase-1 Induces Pulmonary Vascular Endothelial Cell Injury.

Monocyte Caspase-1 Is Released in a Stable, Active High Molecular Weight Complex Distinct from the Unstable Cell Lysate-Activated Caspase-1.

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