Mark D Wewers, MD

Mark Wewers


College of Medicine


Internal Medicine

Academic Title


Research Program

Molecular Carcinogenesis and Chemoprevention

Research Interest

Infection ● Sepsis ● Inflammation ● Emphysema ● Multiple Organ Failure ● tularemia

Mark Wewers, MD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where his research focuses on host defense against pathogens.

In particular, he seeks to understand how the lung and circulating mononuclear phagocytes sense danger from pathogens and respond with robust inflammation around IL-1.

His recent studies address the important role of the inflammasome adaptor ASC as a contributor to lung airway inflammation as well as the regulation of the pyroptosis generating inflammasome mediator, gasdermin D, as a factor in lung cell survival.

Dr. Wewers has co-authored many articles in well-respected publications, including Nature Immunology, Journal of Immunology, Journal of Biological Chemistry and Cell Reports.

Office Location

201 Davis Heart & Lung Research Inst

473 W 12th Ave, Columbus, OH 43210




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