Mark D Wewers, MD

College

College of Medicine

Department/Division

Internal Medicine

Academic Title

Professor

Research Program

Molecular Carcinogenesis and Chemoprevention

Research Interest

Infection, Sepsis, Inflammation, Emphysema, Multiple Organ Failure, tularemia

Dr. Wewer’s research focuses on host defense against pathogens, particularly relevant to the lung and critical to survival His lab is interested in understanding the role of proteins that regulate the activation of the intracellular enzyme, caspase-1. This work is relevant to understanding how the lung and circulating mononuclear phagocytes are capable of sensing danger from pathogens and responding with robuts inflammation centered around IL-1.

Education and Background

Office Location

201 Davis Heart & Lung Research Inst

473 W 12th Avenue, Columbus, Ohio 43210

614-247-7707

614-293-4799

wewers.2@osu.edu

Publications

The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation.

Ratner D, Orning MP, Proulx MK, Wang D, Gavrilin MA, Wewers MD, Alnemri ES, Johnson PF, Lee B, Mecsas J, Kayagaki N, Goguen JD, Lien E

PLoS Pathog 12 e1006035 12/01/2016
Blood-Borne Lipopolysaccharide Is Rapidly Eliminated by Liver Sinusoidal Endothelial Cells via High-Density Lipoprotein.

Yao Z, Mates JM, Cheplowitz AM, Hammer LP, Maiseyeu A, Phillips GS, Wewers MD, Rajaram MV, Robinson JM, Anderson CL, Ganesan LP

J Immunol 197 2390-9 09/15/2016
Ethanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation.

Hoyt LR, Ather JL, Randall MJ, DePuccio DP, Landry CC, Wewers MD, Gavrilin MA, Poynter ME

J Immunol 197 1322-34 08/15/2016
T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis.

Martin BN, Wang C, Zhang CJ, Kang Z, Gulen MF, Zepp JA, Zhao J, Bian G, Do JS, Min B, Pavicic PG Jr, El-Sanadi C, Fox PL, Akitsu A, Iwakura Y, Sarkar A, Wewers MD, Kaiser WJ, Mocarski ES, Rothenberg ME, Hise AG, Dubyak GR, Ransohoff RM, Li X

Nat Immunol 17 583-92 05/01/2016
I?B? Regulates Human Monocyte Pro-Inflammatory Responses Induced by Streptococcus pneumoniae.

Sundaram K, Rahman MA, Mitra S, Knoell DL, Woodiga SA, King SJ, Wewers MD

PLoS One 11 e0161931 01/01/2016
Supernatants from stored red blood cell (RBC) units, but not RBC-derived microvesicles, suppress monocyte function in vitro.

Muszynski JA, Bale J, Nateri J, Nicol K, Wang Y, Wright V, Marsh CB, Gavrilin MA, Sarkar A, Wewers MD, Hall MW

Transfusion 55 1937-45 08/01/2015
Mononuclear Phagocyte-Derived Microparticulate Caspase-1 Induces Pulmonary Vascular Endothelial Cell Injury.

Mitra S, Wewers MD, Sarkar A

PLoS One 10 e0145607 01/01/2015
Monocyte Caspase-1 Is Released in a Stable, Active High Molecular Weight Complex Distinct from the Unstable Cell Lysate-Activated Caspase-1.

Shamaa OR, Mitra S, Gavrilin MA, Wewers MD

PLoS One 10 e0142203 01/01/2015
Alpha 1-antitrypsin does not inhibit human monocyte caspase-1.

Rahman MA, Mitra S, Sarkar A, Wewers MD

PLoS One 10 e0117330 01/01/2015
Inflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function.

Ghonime MG, Shamaa OR, Das S, Eldomany RA, Fernandes-Alnemri T, Alnemri ES, Gavrilin MA, Wewers MD

J Immunol 192 3881-8 04/15/2014
Microvesicular caspase-1 mediates lymphocyte apoptosis in sepsis.

Exline MC, Justiniano S, Hollyfield JL, Berhe F, Besecker BY, Das S, Wewers MD, Sarkar A

PLoS One 9 e90968 01/01/2014
Receptor interacting protein-2 plays a critical role in human lung epithelial cells survival in response to Fas-induced cell-death.

Rahman MA, Sundaram K, Mitra S, Gavrilin MA, Wewers MD

PLoS One 9 e92731 01/01/2014
Interleukin-1 and interferon-? orchestrate ß-glucan-activated human dendritic cell programming via I?B-? modulation.

Cardone M, Dzutsev AK, Li H, Riteau N, Gerosa F, Shenderov K, Winkler-Pickett R, Provezza L, Riboldi E, Leighty RM, Orr SJ, Steinhagen F, Wewers MD, Sher A, Anderson SK, Goldszmid R, McVicar DW, Lyakh L, Trinchieri G

PLoS One 9 e114516 01/01/2014
Alpha-1 antitrypsin augmentation therapy.

Wewers MD, Crystal RG

COPD 10 Suppl 1 64-7 03/01/2013
ZIP8 regulates host defense through zinc-mediated inhibition of NF-?B.

Liu MJ, Bao S, Gálvez-Peralta M, Pyle CJ, Rudawsky AC, Pavlovicz RE, Killilea DW, Li C, Nebert DW, Wewers MD, Knoell DL

Cell Rep 3 386-400 02/21/2013
Analysis of human bronchial epithelial cell proinflammatory response to Burkholderia cenocepacia infection: inability to secrete il-1ß.

Gillette DD, Shah PA, Cremer T, Gavrilin MA, Besecker BY, Sarkar A, Knoell DL, Cormet-Boyaka E, Wewers MD, Butchar JP, Tridandapani S

J Biol Chem 288 3691-5 02/08/2013
Tyrosine phosphatase inhibition induces an ASC-dependent pyroptosis.

Ghonime MG, Shamaa OR, Eldomany RA, Gavrilin MA, Wewers MD

Biochem Biophys Res Commun 425 384-9 08/24/2012

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Mark D Wewers, MD

College

Department/Division

Academic Title

Research Program

Research Interest

Education and Background

Office Location

Publications

The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation.

Blood-Borne Lipopolysaccharide Is Rapidly Eliminated by Liver Sinusoidal Endothelial Cells via High-Density Lipoprotein.

Ethanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation.

T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis.

I?B? Regulates Human Monocyte Pro-Inflammatory Responses Induced by Streptococcus pneumoniae.

Supernatants from stored red blood cell (RBC) units, but not RBC-derived microvesicles, suppress monocyte function in vitro.

Mononuclear Phagocyte-Derived Microparticulate Caspase-1 Induces Pulmonary Vascular Endothelial Cell Injury.

Monocyte Caspase-1 Is Released in a Stable, Active High Molecular Weight Complex Distinct from the Unstable Cell Lysate-Activated Caspase-1.

Alpha 1-antitrypsin does not inhibit human monocyte caspase-1.

Inflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function.

Microvesicular caspase-1 mediates lymphocyte apoptosis in sepsis.

Receptor interacting protein-2 plays a critical role in human lung epithelial cells survival in response to Fas-induced cell-death.

Interleukin-1 and interferon-? orchestrate ß-glucan-activated human dendritic cell programming via I?B-? modulation.

Alpha-1 antitrypsin augmentation therapy.

ZIP8 regulates host defense through zinc-mediated inhibition of NF-?B.

Analysis of human bronchial epithelial cell proinflammatory response to Burkholderia cenocepacia infection: inability to secrete il-1ß.

Tyrosine phosphatase inhibition induces an ASC-dependent pyroptosis.

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