Mark D Wewers, MD

Research Interest

Infection ● Sepsis ● Inflammation ● Emphysema ● Multiple Organ Failure ● tularemia

Mark Wewers, MD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where his research focuses on host defense against pathogens.

In particular, he seeks to understand how the lung and circulating mononuclear phagocytes sense danger from pathogens and respond with robust inflammation around IL-1.

His recent studies address the important role of the inflammasome adaptor ASC as a contributor to lung airway inflammation as well as the regulation of the pyroptosis generating inflammasome mediator, gasdermin D, as a factor in lung cell survival.

Dr. Wewers has co-authored many articles in well-respected publications, including Nature Immunology, Journal of Immunology, Journal of Biological Chemistry and Cell Reports.