Nicholas Denko, MD, PhD

Nicholas Denko


College of Medicine


Radiation Oncology

Academic Title

Assoc Professor

Research Program

Molecular Biology and Cancer Genetics

Research Interest

Cancer ● Anoxia ● Endoplasmic Reticulum Stress ● Precursor Cell Lymphoblastic Leukemia-Lymphoma ● Multiple Myeloma ● Glioblastoma

Nicholas Denko, MD, PhD, a member of the Molecular Biology and Cancer Genetics Program at the OSUCCC – James, is the co-holder of two U.S. patents related to medical research. One is for the separation of large DNA molecules in alternating asymmetric electrical fields, and the other is for the manipulation of oxygen metabolism to achieve radiosensitization.

He focuses his research on the study of physiology that is unique to the solid tumor, including gene expression changes caused by oxygen deprivation and nutrient stress. He then looks at the impact of the gene expression changes on changes in tumor metabolism and response to conventional therapies.

Dr. Denko has co-authored more than 70 articles appearing in well-respected publications, including Proceedings of the National Academy of Science, Cell Metabolism, Molecular Cancer Therapeutics, International Journal of Cancer and Blood. In addition, he has made more than 30 presentations around the world to medical research gatherings, including the International Conference on Tumor Cell Metabolism, Nature’s Aegean Conference on Tumor Microenvironment and Cellular Stress, and the American Association for Cancer Research.


  • MD, University of Cincinnati College of Medicine

    Cincinnati, OH (USA)

  • Fellowship, March of Dimes Birth Defects Foundation

  • Fellowship, Milheim Cancer Research Foundation

  • Fellowship, Stanford University

    Stanford, CA (USA)

  • Fellowship, National Research Service Awards


  • Department of Radiation Oncology

    Stanford University School of Medicine

    Stanford, CA (USA)


  • Cancer Biology Postdoctoral Fellowship

    Stanford University

    Stanford, CA (USA)

  • Individual Postdoctoral Fellowship

    National Research Service Awards

  • Predoctoral Fellowship: Analysis of Ha-ras induced Genomic Instability

    Milheim Cancer Research Foundation

  • Predoctoral Graduate Research Training Fellowship FY91-0435

    March of Dimes Birth Defects Foundation

Office Location

524 Tzagournis Mes Res Facility

420 W 12th Ave, Columbus, OH 43210



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