Nyla A Heerema, PhD

Nyla Heerema

College

College of Medicine

Department/Division

Pathology

Academic Title

Professor

Research Program

Leukemia Research

Research Interest

Precursor Cell Lymphoblastic Leukemia-Lymphoma, Cancer, Leukemia, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myeloid, Acute, Chromosome Aberrations, Down Syndrome, Cancer, Germ Cell and Embryonal, Trisomy, Burkitt Lymphoma

My research centers on chromosomal abnormalities in hematological malignancies.  I am particularly involved in research of  chromosome changes in  pediatric acute lymphoblastic leukemia (ALL )  and their clinical significance,  including the use of fluorescence in situ hybridization (FISH)  for patient risk stratification in Children’s Oncology Group (COG) clinical trials.  This is a large, collaborative effort, and I am in charge of all cytogenetic studies of the COG, including collection of data, review of cases, data entry and management, and analyses.  In adult leukemias, I am using FISH in chronic lymphocytic leukemia (CLL) to detect specific aberrations and determine possible correlations with clinical parameters, significance in response to specific treatments and outcome.  We are investigating metaphase analyses of CLL using novel mitogenic agents  and correlating the results  with clinical parameters, similar to the FISH analyses.  We also are involved in the development and studies of the application of FISH techniques.


Education and Background

Office Location

129 Hamilton Hall

1645 Neil Avenue, Columbus, OH 43210


614-292-7815

614-293-9919



Publications

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