Nyla A Heerema, PhD
College of Medicine
Precursor Cell Lymphoblastic Leukemia-Lymphoma, Cancer, Leukemia, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myeloid, Acute, Chromosome Aberrations, Down Syndrome, Cancer, Germ Cell and Embryonal, Trisomy, Burkitt Lymphoma
My research centers on chromosomal abnormalities in hematological malignancies. I am particularly involved in research of chromosome changes in pediatric acute lymphoblastic leukemia (ALL ) and their clinical significance, including the use of fluorescence in situ hybridization (FISH) for patient risk stratification in Children’s Oncology Group (COG) clinical trials. This is a large, collaborative effort, and I am in charge of all cytogenetic studies of the COG, including collection of data, review of cases, data entry and management, and analyses. In adult leukemias, I am using FISH in chronic lymphocytic leukemia (CLL) to detect specific aberrations and determine possible correlations with clinical parameters, significance in response to specific treatments and outcome. We are investigating metaphase analyses of CLL using novel mitogenic agents and correlating the results with clinical parameters, similar to the FISH analyses. We also are involved in the development and studies of the application of FISH techniques.