Paul R Andreassen, PhD

College

College of Medicine - UC

Department/Division

Pediatrics

Academic Title

Assoc Professor

Research Program

Molecular Biology and Cancer Genetics

Paul Andreassen, PhD, is a member of the OSUCCC – James Molecular Biology and Cancer Genetics Program. He is based at Cincinnati Children’s Hospital Medical Center. His research focuses on the relationship of DNA repair and cell-cycle checkpoints to the genetic instability that underlies cancer development.

He studies basic cellular mechanisms that respond to DNA damage, including breast cancer susceptibility (BRCA) and Fanconi anemia (FA) genes and proteins.

Recently, Dr. Andreassen co-authored a study in the Journal of Medical Genetics that yielded important insights into phenotypes related to FA and its genetic origins. He also has co-authored research appearing in other well-respected publications, including Blood, STEM CELLS and The Journal of Cell Biology.

Education and Background

Office Location

ML S7.203 Division of Experimental Hematology

333 Burnet Avenue, Cincinnati, OH 45229

513-636-0499

Paul.Andreassen@cchmc.org

Publications

DNA repair-related functional assays for the classification of BRCA1 and BRCA2 variants: a critical review and needs assessment.

Toland AE, Andreassen PR

J Med Genet in press 09/02/2017
Manipulating DNA damage-response signaling for the treatment of immune-mediated diseases.

McNally JP, Millen SH, Chaturvedi V, Lakes N, Terrell CE, Elfers EE, Carroll KR, Hogan SP, Andreassen PR, Kanter J, Allen CE, Henry MM, Greenberg JN, Ladisch S, Hermiston ML, Joyce M, Hildeman DA, Katz JD, Jordan MB

Proc Natl Acad Sci U S A 114 E4782-E4791 06/13/2017
Coordination of the recruitment of the FANCD2 and PALB2 Fanconi anemia proteins by an ubiquitin signaling network.

Bick G, Zhang F, Meetei AR, Andreassen PR

Chromosoma 126 417-430 06/01/2017
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.

Zhang T, Du W, Wilson AF, Namekawa SH, Andreassen PR, Meetei AR, Pang Q

Sci Rep 7 45626 04/05/2017
DEK is required for homologous recombination repair of DNA breaks.

Smith EA, Gole B, Willis NA, Soria R, Starnes LM, Krumpelbeck EF, Jegga AG, Ali AM, Guo H, Meetei AR, Andreassen PR, Kappes F, Vinnedge LM, Daniel JA, Scully R, Wiesmüller L, Wells SI

Sci Rep 7 44662 03/20/2017
Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.

Alavattam KG, Kato Y, Sin HS, Maezawa S, Kowalski IJ, Zhang F, Pang Q, Andreassen PR, Namekawa SH

Cell Rep 17 1141-1157 10/18/2016
Complementation of hypersensitivity to DNA interstrand crosslinking agents demonstrates that XRCC2 is a Fanconi anaemia gene.

Park JY, Virts EL, Jankowska A, Wiek C, Othman M, Chakraborty SC, Vance GH, Alkuraya FS, Hanenberg H, Andreassen PR

J Med Genet 53 672-680 10/01/2016
Cytokinesis failure in RhoA-deficient mouse erythroblasts involves actomyosin and midbody dysregulation and triggers p53 activation.

Konstantinidis DG, Giger KM, Risinger M, Pushkaran S, Zhou P, Dexheimer P, Yerneni S, Andreassen P, Klingmüller U, Palis J, Zheng Y, Kalfa TA

Blood 126 1473-82 09/17/2015
FANCB is essential in the male germline and regulates H3K9 methylation on the sex chromosomes during meiosis.

Kato Y, Alavattam KG, Sin HS, Meetei AR, Pang Q, Andreassen PR, Namekawa SH

Hum Mol Genet 24 5234-49 09/15/2015
Loss of Faap20 Causes Hematopoietic Stem and Progenitor Cell Depletion in Mice Under Genotoxic Stress.

Zhang T, Wilson AF, Ali AM, Namekawa SH, Andreassen PR, Meetei AR, Pang Q, Zhang T, Wilson AF, Mahmood Ali A, Namekawa SH, Andreassen PR, Ruhikanta Meetei A, Pang Q

Stem Cells 33 2320-30 07/01/2015
Loss of Faap20 Causes Hematopoietic Stem and Progenitor Cell Depletion in Mice Under Genotoxic Stress.

Zhang T, Wilson AF, Ali AM, Namekawa SH, Andreassen PR, Meetei AR, Pang Q, Zhang T, Wilson AF, Mahmood Ali A, Namekawa SH, Andreassen PR, Ruhikanta Meetei A, Pang Q

Stem Cells 33 2320-30 07/01/2015
BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis.

Broering TJ, Alavattam KG, Sadreyev RI, Ichijima Y, Kato Y, Hasegawa K, Camerini-Otero RD, Lee JT, Andreassen PR, Namekawa SH

J Cell Biol 205 663-75 06/09/2014

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Paul R Andreassen, PhD

College

Department/Division

Academic Title

Research Program

Education and Background

Office Location

Publications

DNA repair-related functional assays for the classification of BRCA1 and BRCA2 variants: a critical review and needs assessment.

Manipulating DNA damage-response signaling for the treatment of immune-mediated diseases.

Coordination of the recruitment of the FANCD2 and PALB2 Fanconi anemia proteins by an ubiquitin signaling network.

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.

DEK is required for homologous recombination repair of DNA breaks.

Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.

Complementation of hypersensitivity to DNA interstrand crosslinking agents demonstrates that XRCC2 is a Fanconi anaemia gene.

Cytokinesis failure in RhoA-deficient mouse erythroblasts involves actomyosin and midbody dysregulation and triggers p53 activation.

FANCB is essential in the male germline and regulates H3K9 methylation on the sex chromosomes during meiosis.

Loss of Faap20 Causes Hematopoietic Stem and Progenitor Cell Depletion in Mice Under Genotoxic Stress.

Loss of Faap20 Causes Hematopoietic Stem and Progenitor Cell Depletion in Mice Under Genotoxic Stress.

BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis.

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