Peter Shields, MD

College

College of Medicine

Department/Division

Internal Medicine

Academic Title

Professor

Research Program

Cancer Control

Research Interest

Carcinoid Tumor

Dr. Shields is a medical oncologist with a focus on the treatment of lung cancer. His research interests are in prevention, with a focus on lung cancer and breast cancer. He studies the causes of cancer and develops biomarkers of cancer risk in order to develop more rational prevention methods and improve early detection of cancer.

Education and Background

Education

BA, University of Pennsylvania

Pennsylvania, PA (USA)
MD, Mount Sinai School of Medicine

New York, NY (USA)
PhD, National Cancer Institute (NCI) and The George Washington University Hospital (Washington, DC) and the

Washington, D.C.

Residencies

Internship, Internal Medicine

The George Washington University Hospital

Washington, DC
Residency, Internal Medicine

The George Washington University Hospital

Washington, DC

Fellowship

Clinical Fellowship, Hematology and Oncology, Joint Program

National Cancer Institute (NCI) and The George Washington University Hospital (Washington, DC) and the

Washington, D.C.

Office Location

D920 James Cancer Hospital & Solove Research Inst

460 W 10th Ave, Columbus, OH 43210

614-366-5868

614-293-3132

shields.167@osu.edu;PETER.SHIELDS@OSUMC.EDU

Publications

Assessment of Tumor Sequencing as a Replacement for Lynch Syndrome Screening and Current Molecular Tests for Patients With Colorectal Cancer.

Beightol M, Shields PG, Goldberg RM, Bacher J, Yilmaz A, Ohio Colorectal Cancer Prevention Initiative Study Group, Frankel WL, Paskett E, de la Chapelle A, Hampel H, Jacobson A, Shirts BH, Pritchard CC, Jones D, Goodfellow PJ, Miller K, Pearlman R, Zhao W

JAMA Oncol in press 03/29/2018
Landscape of genome-wide age-related DNA methylation in breast tissue.

Freudenheim JL, Marian C, Kallakury BVS, Brasky TM, Shields PG, Spear SL, Llanos AA, Ambrosone C, Higgins MJ, Song MA, Weng DY, McElroy JP

Oncotarget 8 114648-114662 12/29/2017
The addition of chemotherapy to radiation therapy improves survival in elderly patients with stage III non-small cell lung cancer.

Otterson GA, Xu-Welliver M, Bertino EM, Williams TM, He K, Shields PG, Carbone DP, Miller ED, Fisher JL, Grecula JC, Haglund KE, Bazan JG

J Thorac Oncol in press 12/18/2017
Strong preference for mint snus flavor among research participants.

Hatsukami DK, Lindgren BR, O'Connor RJ, Shields PG, Schneller LM

Addict Behav Rep 6 51-55 12/01/2017
Cigarette Filter Ventilation and its Relationship to Increasing Rates of Lung Adenocarcinoma.

Song MA, Benowitz NL, Berman M, Brasky TM, Cummings KM, Hatsukami DK, Marian C, O'Connor R, Rees VW, Woroszylo C, Shields PG

J Natl Cancer Inst 109 12/01/2017
Lifetime exposure to ambient air pollution and methylation of tumor suppressor genes in breast tumors.

Eng KH, Callahan CL, Marian C, Beyea J, Bonner MR, Han D, Tao MH, Nie J, Shields PG, Wang Y, Trevisan M, Freudenheim JL

Environ Res in press 11/30/2017
Sleep and Breast Cancer in the Western New York Exposures and Breast Cancer (WEB) Study.

Wactawski-Wende J, Trevisan M, Sucheston-Campbell L, Freudenheim JL, Marian C, Kallakury BV, Ochs-Balcom HM, Shields PG, Vaughn CB, Nie J

J Clin Sleep Med in press 11/29/2017
Consortium on Methods Evaluating Tobacco: Research Tools to Inform FDA Regulation of Snus.

Berman ML, Bickel WK, Harris AC, LeSage MG, O'Connor RJ, Stepanov I, Shields PG, Hatsukami DK

Nicotine Tob Res in press 10/04/2017
Use of Calcium Channel Blockers and Breast Cancer Risk in the Women's Health Initiative.

Brasky TM, Krok-Schoen JL, Liu J, Chlebowski RT, Freudenheim JL, Lavasani S, Margolis KL, Qi L, Reding KW, Shields PG, Simon MS, Wactawski-Wende J, Wang A, Womack C, Manson JE

Cancer Epidemiol Biomarkers Prev 26 1345-1348 08/01/2017
A Review of Pulmonary Toxicity of Electronic Cigarettes in the Context of Smoking: A Focus on Inflammation.

Shields PG, Berman M, Brasky TM, Freudenheim JL, Mathe EA, McElroy J, Song MA, Wewers MD, Mathe E, McElroy JP, Song MA, Wewers MD, Shields PG, Berman M, Brasky TM, Freudenheim JL

Cancer Epidemiol Biomarkers Prev 26 1175-1191 08/01/2017
A Review of Pulmonary Toxicity of Electronic Cigarettes in the Context of Smoking: A Focus on Inflammation.

Shields PG, Berman M, Brasky TM, Freudenheim JL, Mathe EA, McElroy J, Song MA, Wewers MD, Mathe E, McElroy JP, Song MA, Wewers MD, Shields PG, Berman M, Brasky TM, Freudenheim JL

Cancer Epidemiol Biomarkers Prev 26 1175-1191 08/01/2017
Evaluating the utility of subjective effects measures for predicting product sampling, enrollment, and retention in a clinical trial of a smokeless tobacco product.

O'Connor RJ, Lindgren BR, Schneller LM, Shields PG, Hatsukami DK

Addict Behav in press 07/14/2017
Comprehensive population-wide analysis of Lynch syndrome in Iceland reveals founder mutations in MSH6 and PMS2.

Haraldsdottir S, Rafnar T, Frankel WL, Einarsdottir S, Sigurdsson A, Hampel H, Snaebjornsson P, Masson G, Weng D, Arngrimsson R, Kehr B, Yilmaz A, Haraldsson S, Sulem P, Stefansson T, Shields PG, Sigurdsson F, Bekaii-Saab T, Moller PH, Steinarsdottir M, Alexiusdottir K, Hitchins M, Pritchard CC, de la Chapelle A, Jonasson JG, Goldberg RM, Stefansson K

Nat Commun 8 14755 05/03/2017
Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer.

Pearlman R, Frankel WL, Swanson B, Zhao W, Yilmaz A, Miller K, Bacher J, Bigley C, Nelsen L, Goodfellow PJ, Goldberg RM, Paskett E, Shields PG, Freudenheim JL, Stanich PP, Lattimer I, Arnold M, Liyanarachchi S, Kalady M, Heald B, Greenwood C, Paquette I, Prues M, Draper DJ, Lindeman C, Kuebler JP, Reynolds K, Brell JM, Shaper AA, Mahesh S, Buie N, Weeman K, Shine K, Haut M, Edwards J, Bastola S, Wickham K, Khanduja KS, Zacks R, Pritchard CC, Shirts BH, Jacobson A, Allen B, de la Chapelle A, Hampel H, Ohio Colorectal Cancer Prevention Initiative Study Group

JAMA Oncol 3 464-471 04/01/2017
Metabolomic profiles of current cigarette smokers.

Hsu PC, Lan RS, Brasky TM, Marian C, Cheema AK, Ressom HW, Loffredo CA, Pickworth WB, Shields PG

Mol Carcinog 56 594-606 02/01/2017
Menthol Smokers: Metabolomic Profiling and Smoking Behavior.

Hsu PC, Lan RS, Brasky TM, Marian C, Cheema AK, Ressom HW, Loffredo CA, Pickworth WB, Shields PG

Cancer Epidemiol Biomarkers Prev 26 51-60 01/01/2017
Reduced nicotine content cigarettes and use of alternative nicotine products: exploratory trial.

Hatsukami DK, Luo X, Dick L, Kangkum M, Allen SS, Murphy SE, Hecht SS, Shields P, al'Absi M, Hatsukami DK, Luo X, Dick L, Kangkum M, Allen SS, Murphy SE, Hecht SS, Shields PG, al'Absi M

Addiction 112 156-167 01/01/2017
Reduced nicotine content cigarettes and use of alternative nicotine products: exploratory trial.

Hatsukami DK, Luo X, Dick L, Kangkum M, Allen SS, Murphy SE, Hecht SS, Shields P, al'Absi M, Hatsukami DK, Luo X, Dick L, Kangkum M, Allen SS, Murphy SE, Hecht SS, Shields PG, al'Absi M

Addiction 112 156-167 01/01/2017
Discovery and replication of microRNAs for breast cancer risk using genome-wide profiling.

Taslim C, Weng DY, Brasky TM, Dumitrescu RG, Huang K, Kallakury BV, Krishnan S, Llanos AA, Marian C, McElroy J, Schneider SS, Spear SL, Troester MA, Freudenheim JL, Geyer S, Shields PG

Oncotarget 7 86457-86468 12/27/2016
Smoking Cessation, Version 1.2016, NCCN Clinical Practice Guidelines in Oncology.

Shields PG, Herbst RS, Arenberg D, Benowitz NL, Bierut L, Luckart JB, Cinciripini P, Collins B, David S, Davis J, Hitsman B, Hyland A, Lang M, Leischow S, Park ER, Purcell WT, Selzle J, Silber A, Spencer S, Tanvetyanon T, Tiep B, Tindle HA, Tucker-Seeley R, Urbanic J, Hooper MW, Weksler B, Whitlock CW, Wood DE, Burns J, Scavone J

J Natl Compr Canc Netw 14 1430-1468 11/01/2016
Relationship between Overall Survival and Response or Progression-Free Survival in Advanced Non-Small Cell Lung Cancer Patients Treated with Anti-PD-1/PD-L1 Antibodies.

Shukuya T, Mori K, Amann JM, Bertino EM, Otterson GA, Shields PG, Morita S, Carbone DP

J Thorac Oncol 11 1927-1939 11/01/2016
Persistent alterations of gene expression profiling of human peripheral blood mononuclear cells from smokers.

Weng DY, Chen J, Taslim C, Hsu PC, Marian C, David SP, Loffredo CA, Shields PG

Mol Carcinog 55 1424-37 10/01/2016
DNA methylation and breast tumor clinicopathological features: The Western New York Exposures and Breast Cancer (WEB) study.

Callahan CL, Wang Y, Marian C, Weng DY, Eng KH, Tao MH, Ambrosone CB, Nie J, Trevisan M, Smiraglia D, Edge SB, Shields PG, Freudenheim JL

Epigenetics 11 643-652 09/01/2016
Patients with colorectal cancer associated with Lynch syndrome and MLH1 promoter hypermethylation have similar prognoses.

Haraldsdottir S, Hampel H, Wu C, Weng DY, Shields PG, Frankel WL, Pan X, de la Chapelle A, Goldberg RM, Bekaii-Saab T

Genet Med 18 863-8 09/01/2016
Preference for Flavored Noncombustible Nicotine Products Among Smokers Motivated to Switch From Cigarettes.

Meier E, Isaksson Vogel R, O'Connor R, Severson H, Shields P, Hatsukami DK, Meier E, Isaksson Vogel R, O'Connor RJ, Severson HH, Shields PG, Hatsukami DK

Nicotine Tob Res 18 892-3 05/01/2016
Preference for Flavored Noncombustible Nicotine Products Among Smokers Motivated to Switch From Cigarettes.

Meier E, Isaksson Vogel R, O'Connor R, Severson H, Shields P, Hatsukami DK, Meier E, Isaksson Vogel R, O'Connor RJ, Severson HH, Shields PG, Hatsukami DK

Nicotine Tob Res 18 892-3 05/01/2016
Chemical and toxicological characteristics of conventional and low-TSNA moist snuff tobacco products.

Song MA, Marian C, Brasky TM, Reisinger S, Djordjevic M, Shields PG

Toxicol Lett 245 68-77 03/14/2016
Genetic variation in one-carbon metabolism in relation to genome-wide DNA methylation in breast tissue from heathy women.

Song MA, Brasky TM, Marian C, Weng DY, Taslim C, Llanos AA, Dumitrescu RG, Liu Z, Mason JB, Spear SL, Kallakury BV, Freudenheim JL, Shields PG

Carcinogenesis in press 03/09/2016
Single-Nucleotide Polymorphisms and Markers of Oxidative Stress in Healthy Women.

Minlikeeva AN, Browne RW, Ochs-Balcom HM, Marian C, Shields PG, Trevisan M, Krishnan S, Modali R, Seddon M, Lehman T, Freudenheim JL

PLoS One 11 e0156450 01/01/2016
Associations of intakes of magnesium and calcium and survival among women with breast cancer: results from Western New York Exposures and Breast Cancer (WEB) Study.

Tao MH, Dai Q, Millen AE, Nie J, Edge SB, Trevisan M, Shields PG, Freudenheim JL

Am J Cancer Res 6 105-13 01/01/2016
Associations of erythrocyte ?-3 fatty acids with biomarkers of ?-3 fatty acids and inflammation in breast tissue.

Roy S, Brasky TM, Belury MA, Krishnan S, Cole RM, Marian C, Yee LD, Llanos AA, Freudenheim JL, Shields PG

Int J Cancer 137 2934-46 12/15/2015
Adiposity is associated with p53 gene mutations in breast cancer.

Ochs-Balcom HM, Marian C, Nie J, Brasky TM, Goerlitz DS, Trevisan M, Edge SB, Winston J, Berry DL, Kallakury BV, Freudenheim JL, Shields PG

Breast Cancer Res Treat 153 635-45 10/01/2015
Know Your Value: Negotiation Skill Development for Junior Investigators in the Academic Environment--A Report from the American Society of Preventive Oncology's Junior Members Interest Group.

Burton-Chase AM, Swartz MC, Silvera SA, Basen-Engquist K, Fletcher FE, Shields PG

Cancer Epidemiol Biomarkers Prev 24 1144-8 07/01/2015
Telomere length variation: A potential new telomere biomarker for lung cancer risk.

Sun B, Wang Y, Kota K, Shi Y, Motlak S, Makambi K, Loffredo CA, Shields PG, Yang Q, Harris CC, Zheng YL

Lung Cancer 88 297-303 06/01/2015
New NCCN Guidelines: Smoking Cessation for Patients With Cancer.

Shields PG

J Natl Compr Canc Netw 13 643-5 05/01/2015
Providing a Science Base for the Evaluation of Tobacco Products.

Berman ML, Connolly G, Cummings KM, Djordjevic MV, Hatsukami DK, Henningfield JE, Myers M, O'Connor RJ, Parascandola M, Rees V, Rice JM, Shields PG

Tob Regul Sci 1 76-93 04/01/2015
Electronic nicotine delivery systems: a policy statement from the American Association for Cancer Research and the American Society of Clinical Oncology.

Brandon TH, Goniewicz ML, Hanna NH, Hatsukami DK, Herbst RS, Hobin JA, Ostroff JS, Shields PG, Toll BA, Tyne CA, Viswanath K, Warren GW

J Clin Oncol 33 952-63 03/10/2015
Electronic nicotine delivery systems: a policy statement from the American Association for Cancer Research and the American Society of Clinical Oncology.

Brandon TH, Goniewicz ML, Hanna NH, Hatsukami DK, Herbst RS, Hobin JA, Ostroff JS, Shields PG, Toll BA, Tyne CA, Viswanath K, Warren GW

Clin Cancer Res 21 514-25 02/01/2015
Mortality among capacitor workers exposed to polychlorinated biphenyls (PCBs), a long-term update.

Kimbrough RD, Krouskas CA, Xu W, Shields PG

Int Arch Occup Environ Health 88 85-101 01/01/2015
Racial differences in genome-wide methylation profiling and gene expression in breast tissues from healthy women.

Song MA, Brasky TM, Marian C, Weng D, Taslim C, Dumitrescu RG, Llanos AA, Freudenheim JL, Shields PG, Song MA, Brasky TM, Marian C, Weng DY, Taslim C, Dumitrescu RG, Llanos AA, Freudenheim JL, Shields PG

Epigenetics 10 1177-87 01/01/2015
Racial differences in genome-wide methylation profiling and gene expression in breast tissues from healthy women.

Song MA, Brasky TM, Marian C, Weng D, Taslim C, Dumitrescu RG, Llanos AA, Freudenheim JL, Shields PG, Song MA, Brasky TM, Marian C, Weng DY, Taslim C, Dumitrescu RG, Llanos AA, Freudenheim JL, Shields PG

Epigenetics 10 1177-87 01/01/2015
Associations between genetic variation in one-carbon metabolism and LINE-1 DNA methylation in histologically normal breast tissues.

Llanos AA, Marian C, Brasky TM, Dumitrescu RG, Liu Z, Mason JB, Makambi KH, Spear SL, Kallakury BV, Freudenheim JL, Shields PG

Epigenetics 10 727-35 01/01/2015
Relationships among folate, alcohol consumption, gene variants in one-carbon metabolism and p16INK4a methylation and expression in healthy breast tissues.

Llanos AA, Dumitrescu RG, Brasky TM, Liu Z, Mason JB, Marian C, Makambi KH, Spear SL, Kallakury BV, Freudenheim JL, Shields PG, Llanos AA, Dumitrescu RG, Brasky TM, Liu Z, Mason JB, Marian C, Makambi KH, Spear SL, Kallakury BV, Freudenheim JL, Shields PG

Carcinogenesis 36 60-7 01/01/2015
Relationships among folate, alcohol consumption, gene variants in one-carbon metabolism and p16INK4a methylation and expression in healthy breast tissues.

Llanos AA, Dumitrescu RG, Brasky TM, Liu Z, Mason JB, Marian C, Makambi KH, Spear SL, Kallakury BV, Freudenheim JL, Shields PG, Llanos AA, Dumitrescu RG, Brasky TM, Liu Z, Mason JB, Marian C, Makambi KH, Spear SL, Kallakury BV, Freudenheim JL, Shields PG

Carcinogenesis 36 60-7 01/01/2015
Genetic variation in adipokine genes and associations with adiponectin and leptin concentrations in plasma and breast tissue.

Llanos AA, Brasky TM, Mathew J, Makambi KH, Marian C, Dumitrescu RG, Freudenheim JL, Shields PG

Cancer Epidemiol Biomarkers Prev 23 1559-68 08/01/2014
Validation of ZAP-70 methylation and its relative significance in predicting outcome in chronic lymphocytic leukemia.

Claus R, Lucas DM, Ruppert AS, Williams KE, Weng D, Patterson K, Zucknick M, Oakes CC, Rassenti LZ, Greaves AW, Geyer S, Wierda WG, Brown JR, Gribben JG, Barrientos JC, Rai KR, Kay NE, Kipps TJ, Shields P, Zhao W, Grever MR, Plass C, Byrd JC

Blood 124 42-8 07/03/2014
Noninvasive urinary metabolomic profiling identifies diagnostic and prognostic markers in lung cancer.

Mathé EA, Patterson AD, Haznadar M, Manna SK, Krausz KW, Bowman ED, Shields PG, Idle JR, Smith PB, Anami K, Kazandjian DG, Hatzakis E, Gonzalez FJ, Harris CC

Cancer Res 74 3259-70 06/15/2014
Future directions for postdoctoral training in cancer prevention: insights from a panel of experts.

Nelson DE, Faupel-Badger J, Phillips S, Belcher B, Chang S, Abrams DB, Kramer BS, White MC, O'Malley M, Varanasi AP, Fabian CJ, Wiest JS, Colditz GA, Hall K, Shields PG, Weitzel JN

Cancer Epidemiol Biomarkers Prev 23 679-83 04/01/2014
Genome-wide methylation patterns provide insight into differences in breast tumor biology between American women of African and European ancestry.

Ambrosone CB, Young AC, Sucheston LE, Wang D, Yan L, Liu S, Tang L, Hu Q, Freudenheim JL, Shields PG, Morrison CD, Demissie K, Higgins MJ

Oncotarget 5 237-48 01/15/2014
Association of prediagnostic physical activity with survival following breast cancer diagnosis: influence of TP53 mutation status.

Tao MH, Hainaut P, Marian C, Nie J, Ambrosone C, Edge SB, Trevisan M, Dorn J, Shields PG, Freudenheim JL

Cancer Causes Control 24 2177-86 12/01/2013
Pregnancy-related characteristics and breast cancer risk.

Brasky TM, Li Y, Jaworowicz DJ Jr, Potischman N, Ambrosone CB, Hutson AD, Nie J, Shields PG, Trevisan M, Rudra CB, Edge SB, Freudenheim JL

Cancer Causes Control 24 1675-85 09/01/2013
Behavioral and psychosocial responses to genomic testing for colorectal cancer risk.

Graves KD, Leventhal KG, Nusbaum R, Salehizadeh Y, Hooker GW, Peshkin BN, Butrick M, Tuong W, Mathew J, Goerlitz D, Fishman MB, Shields PG, Schwartz MD

Genomics 102 123-30 08/01/2013
BRCA1 polymorphisms and breast cancer epidemiology in the Western New York exposures and breast cancer (WEB) study.

Ricks-Santi LJ, Nie J, Marian C, Ochs-Balcom HM, Trevisan M, Edge SB, Kanaan Y, Freudenheim JL, Shields PG

Genet Epidemiol 37 504-11 07/01/2013