Pui-Kai Li, PhD

College

College of Pharmacy

Academic Title

Assoc Professor

Research Program

Molecular Carcinogenesis and Chemoprevention

Research Interest

Cancer, Breast Cancer, Prostatic Cancer, Glioblastoma, Osteosarcoma, Amnesia

Pui-Kai Li, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where he brings a pharmacological perspective.

His research explores the design, synthesis and biochemical testing of sulfatase inhibitors as possible agents in treatment of hormone-dependent cancers.

One of his recent studies indicates that enhancing protein kinase C beta II (PKCßII) activity may be a therapeutic strategy to mitigate cancer-mediated suppression of the immune system.

Dr. Li has co-authored many articles in well-respected publications, including International Journal of Gynecological Cancer, Bioorganic & Medicinal Chemistry Letters, Cancer Research and International Journal of Cancer.

Office Location

338 Parks Hall

500 W 12th Ave, Columbus, OH 43210

614-688-0253

614-292-2435

li.27@osu.edu

Publications

Niclosamide and its analogs are potent inhibitors of Wnt/ß-catenin, mTOR and STAT3 signaling in ovarian cancer.

Arend RC, Londoño-Joshi AI, Gangrade A, Katre AA, Kurpad C, Li Y, Samant RS, Li PK, Landen CN, Yang ES, Hidalgo B, Alvarez RD, Straughn JM, Forero A, Buchsbaum DJ, Arend RC, Londoño-Joshi AI, Gangrade A, Katre AA, Kurpad C, Li Y, Samant RS, Li PK, Landen CN, Yang ES, Hidalgo B, Alvarez RD, Straughn JM, Forero A, Buchsbaum DJ

Oncotarget 7 86803-86815 12/27/2016
Niclosamide Analogs for Treatment of Ovarian Cancer.

Walters Haygood CL, Arend RC, Gangrade A, Li PK, Hidalgo B, Straughn JM Jr, Buchsbaum DJ, Walters Haygood CL, Arend RC, Gangrade A, Chettiar S, Regan N, Hassmann CJ 2nd, Li PK, Hidalgo B, Straughn JM Jr, Buchsbaum DJ

Int J Gynecol Cancer 25 1377-85 10/01/2015
Niclosamide Analogs for Treatment of Ovarian Cancer.

Walters Haygood CL, Arend RC, Gangrade A, Li PK, Hidalgo B, Straughn JM Jr, Buchsbaum DJ, Walters Haygood CL, Arend RC, Gangrade A, Chettiar S, Regan N, Hassmann CJ 2nd, Li PK, Hidalgo B, Straughn JM Jr, Buchsbaum DJ

Int J Gynecol Cancer 25 1377-85 10/01/2015
Multi-targeted therapy of cancer by niclosamide: A new application for an old drug.

Li PK, Roberts MJ, Arend RC, Samant RS, Buchsbaum DJ, Li Y

Cancer Lett 349 8-14 07/10/2014
Tumor-induced STAT3 signaling in myeloid cells impairs dendritic cell generation by decreasing PKCßII abundance.

Farren MR, Carlson LM, Netherby CS, Lindner I, Li PK, Gabrilovich DI, Abrams SI, Lee KP

Sci Signal 7 ra16 02/18/2014
Structure-activity relationship studies of thalidomide analogs with a taxol-like mode of action.

Pandit B, Hu Z, Chettiar SN, Zink J, Xiao Z, Etter JP, Bhasin D, Li PK

Bioorg Med Chem Lett 23 6902-4 12/15/2013
Antiproliferative activities and SAR studies of substituted anthraquinones and 1,4-naphthoquinones.

Bhasin D, Etter JP, Chettiar SN, Mok M, Li PK

Bioorg Med Chem Lett 23 6864-7 12/15/2013
Phosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cells.

Palmer RH, Hallberg B, Sattu K, Hochgräfe F, Wu J, Umapathy G, Schönherr C, Ruuth K, Chand D, Witek B, Fuchs J, Li PK, Hugosson F, Daly RJ

FEBS J 280 5269-82 11/01/2013
Design, synthesis and biological studies of survivin dimerization modulators that prolong mitotic cycle.

Chettiar SN, Cooley JV, Park IH, Bhasin D, Chakravarti A, Li PK, Li C, Jacob NK

Bioorg Med Chem Lett 23 5429-33 10/01/2013

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Pui-Kai Li, PhD

College

Academic Title

Research Program

Research Interest

Office Location

Publications

Niclosamide and its analogs are potent inhibitors of Wnt/ß-catenin, mTOR and STAT3 signaling in ovarian cancer.

Niclosamide Analogs for Treatment of Ovarian Cancer.

Niclosamide Analogs for Treatment of Ovarian Cancer.

Multi-targeted therapy of cancer by niclosamide: A new application for an old drug.

Tumor-induced STAT3 signaling in myeloid cells impairs dendritic cell generation by decreasing PKCßII abundance.

Structure-activity relationship studies of thalidomide analogs with a taxol-like mode of action.

Antiproliferative activities and SAR studies of substituted anthraquinones and 1,4-naphthoquinones.

Phosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cells.

Design, synthesis and biological studies of survivin dimerization modulators that prolong mitotic cycle.

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