Q Richard Lu, PhD

College

College of Medicine - UC

Department/Division

Pediatrics

Academic Title

Professor

Research Program

Molecular Biology and Cancer Genetics

Dr. Lu's lab has identified a novel tumor suppressor gene GNAS in medulloblastoma and defined an oncogenic role of Olig2 in glioma initiation and progression. Their research goal is to identify the critical molecules and pathways that drive tumorigenesis in glioblastoma and medulloblastoma, and dissect the cells of origin that are competent to form brain tumors, and develop novel effective strategies to treat these deadly pediatric and adult brain cancers.

Education and Background

Office Location

3333 Burnet Ave

3333 Burnet Avenue, Cincinnati, OH 43205

513-636-7684

richard.lu@cchmc.org

Publications

Harnessing OLIG2 Function in Tumorigenicity and Plasticity to Target Malignant Gliomas.

Kosty J, Lu F, Kupp R, Mehta S, Lu QR

Cell Cycle in press 08/14/2017
Folate Metabolism Regulates Oligodendrocyte Survival and Differentiation by Modulating AMPKa Activity.

Weng Q, Wang J, Wang J, Tan B, Wang J, Wang H, Zheng T, Lu QR, Yang B, He Q

Sci Rep 7 1705 05/11/2017
A reciprocal regulatory loop between TAZ/YAP and G-protein Gas regulates Schwann cell proliferation and myelination.

Deng Y, Wu LMN, Bai S, Zhao C, Wang H, Wang J, Xu L, Sakabe M, Zhou W, Xin M, Lu QR

Nat Commun 8 15161 04/26/2017
miR-219 Cooperates with miR-338 in Myelination and Promotes Myelin Repair in the CNS.

Wang H, Moyano AL, Ma Z, Deng Y, Lin Y, Zhao C, Zhang L, Jiang M, He X, Ma Z, Lu F, Xin M, Zhou W, Yoon SO, Bongarzone ER, Lu QR

Dev Cell 40 566-582.e5 03/27/2017
lncRNA Functional Networks in Oligodendrocytes Reveal Stage-Specific Myelination Control by an lncOL1/Suz12 Complex in the CNS.

He D, Wang J, Lu Y, Deng Y, Zhao C, Xu L, Chen Y, Hu YC, Zhou W, Lu QR

Neuron 93 362-378 01/18/2017
Corrigendum: Regulation of PERK-eIF2a signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes.

Jiang M, Liu L, He X, Wang H, Lin W, Wang H, Yoon SO, Wood TL, Lu QR

Nat Commun 7 13767 11/22/2016
Olig2-Targeted G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Survival in Response to Lysolecithin-Induced Demyelination.

Ou Z, Sun Y, Lin L, You N, Liu X, Li H, Ma Y, Cao L, Han Y, Liu M, Deng Y, Yao L, Lu QR, Chen Y

J Neurosci 36 10560-10573 10/12/2016
Olig2 regulates Purkinje cell generation in the early developing mouse cerebellum.

Ju J, Liu Q, Zhang Y, Liu Y, Jiang M, Zhang L, He X, Peng C, Zheng T, Lu QR, Li H

Sci Rep 6 30711 07/29/2016
Regulation of PERK-eIF2a signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes.

Jiang M, Liu L, He X, Wang H, Lin W, Wang H, Yoon SO, Wood TL, Lu QR

Nat Commun 7 12185 07/15/2016

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Q Richard Lu, PhD

College

Department/Division

Academic Title

Research Program

Education and Background

Office Location

Publications

Harnessing OLIG2 Function in Tumorigenicity and Plasticity to Target Malignant Gliomas.

Folate Metabolism Regulates Oligodendrocyte Survival and Differentiation by Modulating AMPKa Activity.

A reciprocal regulatory loop between TAZ/YAP and G-protein Gas regulates Schwann cell proliferation and myelination.

miR-219 Cooperates with miR-338 in Myelination and Promotes Myelin Repair in the CNS.

lncRNA Functional Networks in Oligodendrocytes Reveal Stage-Specific Myelination Control by an lncOL1/Suz12 Complex in the CNS.

Corrigendum: Regulation of PERK-eIF2a signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes.

Olig2-Targeted G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Survival in Response to Lysolecithin-Induced Demyelination.

Olig2 regulates Purkinje cell generation in the early developing mouse cerebellum.

Regulation of PERK-eIF2a signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes.

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Q Richard Lu, PhD

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