Ramesh K Ganju, PhD
College of Medicine
Molecular Biology and Cancer Genetics
Breast Cancer, Lung Cancer, Neoplasm Metastasis, Inflammation, Tumor Microenvironment, Signal Transduction
Ramesh Ganju, PhD, is a professor and vice chair of experimental pathology in the Department of Pathology at Ohio State, where he is also a researcher in the Molecular Biology and Cancer Genetics Program at the OSUCCC – James.The major focus of Dr. Ganju’s laboratory is to elucidate mechanisms that regulate tumor growth and metastasis (spread). His team is also developing immune-based therapies for solid tumors. Dr. Ganju and colleagues have identified signaling pathways that regulate tumor growth, chemo-invasion and metastasis of tumor cells, especially in breast cancer. In particular, his team has discovered several biomarkers and signaling molecules that regulate growth and metastasis of triple-negative breast cancer (TNBC), including fatty acid binding protein 5 and transient receptor potential vanilloid type-2 (TRPV2). One of his recent projects indicated for the first time that TRPV2 could be a good prognostic marker for TNBC and estrogen receptor alpha-negative (ERa-) breast cancer patients, especially among patients who receive chemotherapy.