Rene Anand, MS, PhD

Rene Anand

College

College of Medicine

Department/Division

Biological Chemistry & Pharmacology

Academic Title

Professor

Research Program

Molecular Biology and Cancer Genetics

Research Interest

Schizophrenia, Chromosome Deletion, Neuroblastoma

As a member of the Molecular Biology and Cancer Genetics team at the OSUCCC – James, Rene Anand, PhD, along with his laboratory, has recently developed human adult stem cell (iPSC) derived models of cancer, autism and Alzheimer’s disease. In particular, Dr. Anand’s work focuses on understanding how genes and the environment give rise to such debilitating brain diseases.

Dr. Anand’s laboratory has independently generated human iPSC-derived synthetic neural organoids which exhibit a remarkable level of development that morphologically resembles a nearly complete human embryonic central nervous system at ~5 week in utero development, but after ~12 weeks in culture in vitro. Using a proprietary process, Dr. Anand and his team have engineered neural organoids from Alzheimer’s disease and tuberous sclerosis patient skin cells with identified genetic mutations in susceptibility genes. His lab’s transcriptomics results remarkably show comprehensive and accurate correlation of the dysregulated expression of hundreds of genes previously correlated with the clinical symptoms and/or pathologies of both of these diseases.

His team’s “NexGen” synthetic neural organoid models allow them to use whole genome transcriptomic to monitor changes in gene expression in response of the models to genetic or environmental perturbations of human brain physiology making their models useful for disease research and drug discovery efforts.


Education and Background

Office Location

1008 Biomedical Research Tower

460 W 12th Ave, Columbus, OH 43210


614-292-7232



Publications

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