Rene Anand, MS, PhD
College of Medicine
Biological Chemistry & Pharmacology
Molecular Biology and Cancer Genetics
Schizophrenia ● Chromosome Deletion ● Neuroblastoma
As a member of the Molecular Biology and Cancer Genetics team at the OSUCCC – James, Rene Anand, PhD, along with his laboratory, has recently developed human adult stem cell (iPSC) derived models of cancer, autism and Alzheimer’s disease. In particular, Dr. Anand’s work focuses on understanding how genes and the environment give rise to such debilitating brain diseases.
Dr. Anand’s laboratory has independently generated human iPSC-derived synthetic neural organoids which exhibit a remarkable level of development that morphologically resembles a nearly complete human embryonic central nervous system at ~5 week in utero development, but after ~12 weeks in culture in vitro. Using a proprietary process, Dr. Anand and his team have engineered neural organoids from Alzheimer’s disease and tuberous sclerosis patient skin cells with identified genetic mutations in susceptibility genes. His lab’s transcriptomics results remarkably show comprehensive and accurate correlation of the dysregulated expression of hundreds of genes previously correlated with the clinical symptoms and/or pathologies of both of these diseases.
His team’s “NexGen” synthetic neural organoid models allow them to use whole genome transcriptomic to monitor changes in gene expression in response of the models to genetic or environmental perturbations of human brain physiology making their models useful for disease research and drug discovery efforts.