Ruoning Wang, PhD

Ruoning Wang


College of Medicine



Academic Title

Asst Professor

Research Program

Molecular Biology and Cancer Genetics

Research Interest

Cancer ● Inflammation ● Cholangiocarcinoma

Ruoning Wang, PhD, is a member of the Molecular Biology and Cancer Genetics Program at the OSUCCC – James. His research explores the impact of the interplay between nutrients-mediated metabolic programs and cellular-signaling cascades on cancer cells (particularly pediatric cancer) and immune cells.

Dr. Wang’s laboratory has used a combination of approaches including murine genetic models of tumor and autoimmune diseases, cellular oncology, immunology and biochemistry, as well as the model organism, frog oocytes, to study fundamental biological questions involved in cell metabolism, cell signaling cascades, cell cycle and death.

His current work focuses on providing a framework for understanding the cellular responses to metabolic insult, coining the term “metabolic checkpoint” to refer to the signaling response that permits adaptation to changes in the metabolic state that would otherwise lead to cell death or cell cycle arrest; gaining a comprehensive understanding of the metabolic heterogeneity of immune and cancer cells, as well as the fundamental principles of the emerging connections between the tumor’s microenvironment, cellular metabolism and anti-tumor immunity; delineating the metabolic signatures of immune cells and tumors, and addressing how the altered metabolic landscape of the tumor’s microenvironment affects the immunosuppressive nature of the tumor’s microenvironment; and fhow to translate our knowledge into novel therapeutic strategies for the treatment of cancers and immune diseases.

Dr. Wang has co-authored many articles in such well-respected publications as Cell, Nature, eLife and PNAS. His research has been supported by 11 investigator-initiated extramural grants (including the National Cancer Institute, the National Institute of Allergy and Infectious Disease, the American Cancer Society and V-foundation) and four intramural grants.


  • Fellowship, University of Texas MD Anderson Cancer Center

    Houston, TX (USA)

  • Fellowship, St Jude Children Research Hospital Department of Immunology

    Memphis, TN (USA)


  • Postdoctoral Fellow

    University of Texas MD Anderson Cancer Center

    Houston, TX (USA)

  • Postdoctoral Fellowship

    St Jude Children Research Hospital Department of Immunology

    Memphis, TN (USA)

Office Location


700 Children's Drive, Columbus, OH 43205




Back to Researcher Search

Please enter a keyword (i.e. Name, Research Interest) or choose a Research Program


Please enter a keyword (i.e. Name, Cancer Type) or choose a Principle Investigator


Search for Clinical Trials

Find a Scientific Publication