Samir Acharya, PhD
College of Medicine
Cancer Biology and Genetics
Molecular Carcinogenesis and Chemoprevention
I am interested in deciphering the intersection of genomic stability and cellular growth/survival. Specifically, my research addresses the effects of DNA repair defects on nucleolar stress, and its manifestation in cellular growth and cellular transformation. These studies are aimed at understanding the molecular basis of growth-defects and cancers associated with the cancer-predisposition disease, Bloom’s syndrome. To achieve this, I use comprehensive biochemical and genetic analyses of Bloom’s helicase in the context of its numerous DNA repair protein partners and post-translational modifications. My long-term objectives are to use the insight obtained through our studies to develop strategies to prevent tumor growth.