Samir Acharya, PhD
College of Medicine
Cancer Biology and Genetics
Senior Research Scientist
Molecular Carcinogenesis and Chemoprevention
Samir Acharya, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where his research focuses on deciphering the intersection of genomic stability and cell growth/survival to develop strategies to prevent tumor growth.In particular, he explores the molecular basis of growth defects and cancers associated with Bloom syndrome, a cancer-predisposition disease. He is the co-holder of a patent for compositions, kits and methods for affecting adenine nucleotide modulation of DNA mismatch recognition proteins. Dr. Acharya’s work has led to new insights into DNA repair, including the discovery of the mechanism of DNA mismatch repair and a conserved motif in mismatch recognition proteins that regulates and coordinates mismatch repair. His work uncovered novel roles of Bloom’s syndrome protein, BLM, in ribosomal RNA transcription, cellular growth and telomere metabolism. He has co-authored numerous articles in such well-respected publications as PNAS, Cell, Molecular Cell, Molecular Microbiology and Human Molecular Genetics.