Samson T Jacob, PhD

Samson Jacob


College of Medicine


Molecular Genetics

Academic Title

Faculty Emeritus

Research Program

Translational Therapeutics

Research Interest

Cancer ● Carcinoma, Hepatocellular ● Liver Cancer, Experimental ● Lymphoma, Non-Hodgkin

Samson Jacob, PhD, is a member of the Translational Therapeutics Program at the OSUCCC – James, where his research focuses on epigenetic silencing of tumor suppressors and delineating the role of microRNAs.

In particular, he uses cells in culture and animal models to study epigenetic silence in the stages of tumorigenesis. He also seeks to understand how microRNAs affect initiation and progression of hepatocellular carcinoma and breast cancer, and their resistance to powerful anti-cancer drugs.

One of his recent studies determined that protein arginine methyltransferase 5 (PRMT5) inhibition offers promise as a novel therapeutic approach for B-cell lymphomas.

Dr. Jacob has co-authored many articles in well-respected publications, such as Blood, Leukemia, Hepatology and Journal of Biological Chemistry.

Office Location

646A Tzagournis Med Res Facility

420 W 12th Ave, Columbus, OH 43210




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