Steve Oghumu, PhD

College

College of Medicine

Department/Division

Pathology

Academic Title

Assistant Professor

Research Program

Molecular Carcinogenesis and Chemoprevention

Steve Oghumu, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where his research focuses on the molecular mechanisms of oral carcinogenesis and black raspberry-mediated oral chemoprevention.

He seeks to identify discrete significant mediators that can be exploited in preventive or therapeutic strategies to reduce oral cancer development risk.

One of his recent research projects indicates targeting macrophage migration inhibitory factor (MIF) is a promising strategy for oral cancer prevention or therapy.

Dr. Oghumu has co-authored numerous articles appearing in well-known publications, including International Journal of Cancer, International Journal of Pharmaceutics and Molecular Oncology.

Office Location

337 Hamilton Hall

1645 Neil Ave, Columbus, OH 43210

614-685-7556

614-292-4053

Steve.Oghumu@osumc.edu

Publications

Role of mast cells in the generation of a T-helper type 2 dominated anti-helminthic immune response.

Ryan NM, Oghumu S

Biosci Rep 39 02/28/2019
The Potent ITK/BTK Inhibitor Ibrutinib Is Effective for the Treatment of Experimental Visceral Leishmaniasis Caused by Leishmania donovani.

Varikuti S, Volpedo G, Saljoughian N, Hamza OM, Halsey G, Ryan NM, Sedmak BE, Seidler GR, Papenfuss TL, Oghumu S, Satoskar AR

J Infect Dis 219 599-608 01/29/2019
MicroRNA Profiling of Salivary Duct Carcinoma Versus Her2/Neu Overexpressing Breast Carcinoma Identify miR-10a as a Putative Breast Related Oncogene.

Balatti V, Oghumu S, Bottoni A, Maharry K, Cascione L, Fadda P, Parwani A, Croce C, Iwenofu OH

Head Neck Pathol in press 09/26/2018
Ly6Chi inflammatory monocytes promote susceptibility to Leishmania donovani infection.

Terrazas C, Varikuti S, Oghumu S, Steinkamp HM, Ardic N, Kimble J, Nakhasi H, Satoskar AR

Sci Rep 7 14693 10/31/2017
In situ immunopathological changes in cutaneous leishmaniasis due to Leishmania donovani.

Manamperi NH, Oghumu S, Pathirana N, de Silva MV, Abeyewickreme W, Satoskar AR, Karunaweera ND

Parasite Immunol 39 03/01/2017
In situ immunopathological changes in cutaneous leishmaniasis due to Leishmania donovani.

Manamperi NH, Oghumu S, Pathirana N, de Silva MV, Abeyewickreme W, Satoskar AR, Karunaweera ND

Parasite Immunol 39 03/01/2017
Pentalinonsterol, a Constituent of Pentalinon andrieuxii, Possesses Potent Immunomodulatory Activity and Primes T Cell Immune Responses.

Oghumu S, Varikuti S, Saljoughian N, Terrazas C, Huntsman AC, Parinandi NL, Fuchs JR, Kinghorn AD, Satoskar AR

J Nat Prod 80 2515-2523 01/22/2017
Helminth-induced Ly6Chi monocyte-derived alternatively activated macrophages suppress experimental autoimmune encephalomyelitis.

Terrazas C, de Dios Ruiz-Rosado J, Amici SA, Jablonski KA, Martinez-Saucedo D, Webb LM, Cortado H, Robledo-Avila F, Oghumu S, Satoskar AR, Rodriguez-Sosa M, Terrazas LI, Guerau-de-Arellano M, Partida-Sánchez S

Sci Rep 7 40814 01/17/2017
STAT1 gene deficient mice develop accelerated breast cancer growth and metastasis which is reduced by IL-17 blockade.

Varikuti S, Oghumu S, Elbaz M, Volpedo G, Ahirwar DK, Alarcon PC, Sperling RH, Moretti E, Pioso MS, Kimble J, Nasser MW, Ganju RK, Terrazas C, Satoskar AR

Oncoimmunology 6 e1361088 01/01/2017
Inhibition of Pro-inflammatory and Anti-apoptotic Biomarkers during Experimental Oral Cancer Chemoprevention by Dietary Black Raspberries.

Oghumu S, Casto BC, Ahn-Jarvis J, Weghorst LC, Maloney J, Geuy P, Horvath KZ, Bollinger CE, Warner BM, Summersgill KF, Weghorst CM, Knobloch TJ

Front Immunol 8 1325 01/01/2017
A Tec kinase BTK inhibitor ibrutinib promotes maturation and activation of dendritic cells.

Natarajan G, Oghumu S, Terrazas C, Varikuti S, Byrd JC, Satoskar AR

Oncoimmunology 5 e1151592 06/01/2016
Host-mediated Leishmania donovani treatment using AR-12 encapsulated in acetalated dextran microparticles.

Collier MA, Peine KJ, Gautam S, Oghumu S, Varikuti S, Borteh H, Papenfuss TL, Sataoskar AR, Bachelder EM, Ainslie KM

Int J Pharm 499 186-194 02/29/2016
Endothelial Robo4 suppresses breast cancer growth and metastasis through regulation of tumor angiogenesis.

Zhao H, Ahirwar DK, Oghumu S, Wilkie T, Powell CA, Nasser MW, Satoskar AR, Li DY, Ganju RK

Mol Oncol 10 272-81 02/01/2016
Endothelial Robo4 suppresses breast cancer growth and metastasis through regulation of tumor angiogenesis.

Zhao H, Ahirwar DK, Oghumu S, Wilkie T, Powell CA, Nasser MW, Satoskar AR, Li DY, Ganju RK

Mol Oncol 10 272-81 02/01/2016
Deletion of macrophage migration inhibitory factor inhibits murine oral carcinogenesis: Potential role for chronic pro-inflammatory immune mediators.

Oghumu S, Knobloch TJ, Terrazas C, Varikuti S, Ahn-Jarvis J, Bollinger CE, Iwenofu H, Weghorst CM, Satoskar AR

Int J Cancer 139 1379-90 01/15/2016
Transgenic T cell-specific expression of CXCR3 enhances splenic and hepatic T cell accumulation but does not affect the outcome of visceral leishmaniasis.

Varikuti S, Natarajan G, Oghumu S, Sperling RH, Moretti E, Stock J, Papenfuss TL, Satoskar AR

Cell Immunol 309 61-68 01/01/2016
STAT4 is required for the generation of Th1 and Th2, but not Th17 immune responses during monophosphoryl lipid A adjuvant activity.

Varikuti S, Oghumu S, Natarajan G, Kimble J, Sperling RH, Moretti E, Kaplan MH, Satoskar AR

Int Immunol 28 565-570 01/01/2016
Differential gene expression pattern in biopsies with renal allograft pyelonephritis and allograft rejection.

Oghumu S, Nori U, Bracewell A, Zhang J, Bott C, Nadasdy GM, Brodsky SV, Pelletier R, Satoskar AR, Nadasdy T, Satoskar AA

Clin Transplant 30 1115-33 01/01/2016
Pediatric Cutaneous Leishmaniasis in an Endemic Region in Turkey: A Retrospective Analysis of 8786 Cases during 1998-2014.

Aksoy M, Doni N, Ozkul HU, Yesilova Y, Ardic N, Yesilova A, Ahn-Jarvis J, Oghumu S, Terrazas C, Satoskar AR

PLoS Negl Trop Dis 10 e0004835 01/01/2016
A Novel Sterol Isolated from a Plant Used by Mayan Traditional Healers Is Effective in Treatment of Visceral Leishmaniasis Caused by Leishmania donovani.

Gupta G, Peine KJ, Abdelhamid D, Snider H, Shelton AB, Rao L, Kotha SR, Huntsman AC, Varikuti S, Oghumu S, Naman CB, Pan L, Parinandi NL, Papenfuss TL, Kinghorn AD, Bachelder EM, Ainslie KM, Fuchs JR, Satoskar AR

ACS Infect Dis 1 497-506 10/09/2015
Modulation of the tumor microenvironment and inhibition of EGF/EGFR pathway: novel anti-tumor mechanisms of Cannabidiol in breast cancer.

Elbaz M, Nasser MW, Ravi J, Wani NA, Ahirwar DK, Zhao H, Oghumu S, Satoskar AR, Shilo K, Carson WE 3rd, Ganju RK

Mol Oncol 9 906-19 04/01/2015

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Steve Oghumu, PhD

College

Department/Division

Academic Title

Research Program

Office Location

Publications

Role of mast cells in the generation of a T-helper type 2 dominated anti-helminthic immune response.

The Potent ITK/BTK Inhibitor Ibrutinib Is Effective for the Treatment of Experimental Visceral Leishmaniasis Caused by Leishmania donovani.

MicroRNA Profiling of Salivary Duct Carcinoma Versus Her2/Neu Overexpressing Breast Carcinoma Identify miR-10a as a Putative Breast Related Oncogene.

Ly6Chi inflammatory monocytes promote susceptibility to Leishmania donovani infection.

In situ immunopathological changes in cutaneous leishmaniasis due to Leishmania donovani.

In situ immunopathological changes in cutaneous leishmaniasis due to Leishmania donovani.

Pentalinonsterol, a Constituent of Pentalinon andrieuxii, Possesses Potent Immunomodulatory Activity and Primes T Cell Immune Responses.

Helminth-induced Ly6Chi monocyte-derived alternatively activated macrophages suppress experimental autoimmune encephalomyelitis.

STAT1 gene deficient mice develop accelerated breast cancer growth and metastasis which is reduced by IL-17 blockade.

Inhibition of Pro-inflammatory and Anti-apoptotic Biomarkers during Experimental Oral Cancer Chemoprevention by Dietary Black Raspberries.

A Tec kinase BTK inhibitor ibrutinib promotes maturation and activation of dendritic cells.

Host-mediated Leishmania donovani treatment using AR-12 encapsulated in acetalated dextran microparticles.

Endothelial Robo4 suppresses breast cancer growth and metastasis through regulation of tumor angiogenesis.

Endothelial Robo4 suppresses breast cancer growth and metastasis through regulation of tumor angiogenesis.

Deletion of macrophage migration inhibitory factor inhibits murine oral carcinogenesis: Potential role for chronic pro-inflammatory immune mediators.

Transgenic T cell-specific expression of CXCR3 enhances splenic and hepatic T cell accumulation but does not affect the outcome of visceral leishmaniasis.

STAT4 is required for the generation of Th1 and Th2, but not Th17 immune responses during monophosphoryl lipid A adjuvant activity.

Differential gene expression pattern in biopsies with renal allograft pyelonephritis and allograft rejection.

Pediatric Cutaneous Leishmaniasis in an Endemic Region in Turkey: A Retrospective Analysis of 8786 Cases during 1998-2014.

A Novel Sterol Isolated from a Plant Used by Mayan Traditional Healers Is Effective in Treatment of Visceral Leishmaniasis Caused by Leishmania donovani.

Modulation of the tumor microenvironment and inhibition of EGF/EGFR pathway: novel anti-tumor mechanisms of Cannabidiol in breast cancer.

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