Steve Oghumu, PhD

College

College of Public Health

Academic Title

Research Scientist

Research Program

Molecular Carcinogenesis and Chemoprevention

Dr. Oghumu's research is focused on understanding the molecular mechanisms of oral carcinogenesis and black raspberry-mediated oral chemoprevention. His long-term goal is to identify discrete significant mediators of oral carcinogenesis that can be exploited in preventive and/or therapeutic strategies to reduce the risk of oral cancer development.

Education and Background

Office Location

400A Cunz Hall

1841 Neil Ave, Columbus, OH 43210

614-292-4053

Steve.Oghumu@osumc.edu

Publications

Ly6C(hi) inflammatory monocytes promote susceptibility to Leishmania donovani infection.

Terrazas C, Varikuti S, Oghumu S, Steinkamp HM, Ardic N, Kimble J, Nakhasi H, Satoskar AR

Sci Rep 7 14693 10/31/2017
Pentalinonsterol, a Constituent of Pentalinon andrieuxii, Possesses Potent Immunomodulatory Activity and Primes T Cell Immune Responses.

Oghumu S, Varikuti S, Saljoughian N, Terrazas C, Huntsman AC, Parinandi NL, Fuchs JR, Kinghorn AD, Satoskar AR

J Nat Prod in press 09/06/2017
In situ immunopathological changes in cutaneous leishmaniasis due to Leishmania donovani.

Manamperi NH, Oghumu S, Pathirana N, de Silva VC, Abeyewickreme W, Satoskar AR, Karunaweera ND, Manamperi NH, Oghumu S, Pathirana N, de Silva MV, Abeyewickreme W, Satoskar AR, Karunaweera ND

Parasite Immunol 39 03/01/2017
In situ immunopathological changes in cutaneous leishmaniasis due to Leishmania donovani.

Manamperi NH, Oghumu S, Pathirana N, de Silva VC, Abeyewickreme W, Satoskar AR, Karunaweera ND, Manamperi NH, Oghumu S, Pathirana N, de Silva MV, Abeyewickreme W, Satoskar AR, Karunaweera ND

Parasite Immunol 39 03/01/2017
Helminth-induced Ly6C(hi) monocyte-derived alternatively activated macrophages suppress experimental autoimmune encephalomyelitis.

Terrazas C, de Dios Ruiz-Rosado J, Amici SA, Jablonski KA, Martinez-Saucedo D, Webb LM, Cortado H, Robledo-Avila F, Oghumu S, Satoskar AR, Rodriguez-Sosa M, Terrazas LI, Guerau-de-Arellano M, Partida-Sánchez S

Sci Rep 7 40814 01/17/2017
STAT1 gene deficient mice develop accelerated breast cancer growth and metastasis which is reduced by IL-17 blockade.

Terrazas C, Moretti E, Alarcon PC, Kimble J, Ahirwar DK, Nasser MW, Volpedo G, Varikuti S, Ganju RK, Satoskar AR, Oghumu S, Elbaz M, Sperling RH, Pioso MS

Oncoimmunology 6 e1361088 01/01/2017
Inhibition of Pro-inflammatory and Anti-apoptotic Biomarkers during Experimental Oral Cancer Chemoprevention by Dietary Black Raspberries.

Bollinger CE, Geuy P, Weghorst CM, Oghumu S, Summersgill KF, Horvath KZ, Weghorst LC, Maloney J, Casto BC, Knobloch TJ, Ahn-Jarvis J, Warner BM

Front Immunol 8 1325 01/01/2017
STAT4 is required for the generation of Th1 and Th2, but not Th17 immune responses during monophosphoryl lipid A adjuvant activity.

Varikuti S, Oghumu S, Natarajan G, Kimble J, Sperling RH, Moretti E, Kaplan MH, Satoskar AR

Int Immunol 28 565-570 11/01/2016
Transgenic T cell-specific expression of CXCR3 enhances splenic and hepatic T cell accumulation but does not affect the outcome of visceral leishmaniasis.

Varikuti S, Natarajan G, Oghumu S, Sperling RH, Moretti E, Stock J, Papenfuss TL, Satoskar AR

Cell Immunol 309 61-68 11/01/2016
Deletion of macrophage migration inhibitory factor inhibits murine oral carcinogenesis: Potential role for chronic pro-inflammatory immune mediators.

Oghumu S, Knobloch TJ, Terrazas C, Varikuti S, Ahn-Jarvis J, Bollinger CE, Iwenofu H, Weghorst CM, Satoskar AR

Int J Cancer 139 1379-90 09/15/2016
Differential gene expression pattern in biopsies with renal allograft pyelonephritis and allograft rejection.

Oghumu S, Nori U, Bracewell A, Zhang J, Bott C, Nadasdy GM, Brodsky SV, Pelletier R, Satoskar AR, Nadasdy T, Satoskar AA

Clin Transplant 30 1115-33 09/01/2016
Pediatric Cutaneous Leishmaniasis in an Endemic Region in Turkey: A Retrospective Analysis of 8786 Cases during 1998-2014.

Aksoy M, Doni N, Ozkul HU, Yesilova Y, Ardic N, Yesilova A, Ahn-Jarvis J, Oghumu S, Terrazas C, Satoskar AR

PLoS Negl Trop Dis 10 e0004835 07/01/2016
A Tec kinase BTK inhibitor ibrutinib promotes maturation and activation of dendritic cells.

Natarajan G, Oghumu S, Terrazas C, Varikuti S, Byrd JC, Satoskar AR

Oncoimmunology 5 e1151592 06/01/2016
Host-mediated Leishmania donovani treatment using AR-12 encapsulated in acetalated dextran microparticles.

Collier MA, Peine KJ, Gautam S, Oghumu S, Varikuti S, Borteh H, Papenfuss TL, Sataoskar AR, Bachelder EM, Ainslie KM

Int J Pharm 499 186-194 02/29/2016
Endothelial Robo4 suppresses breast cancer growth and metastasis through regulation of tumor angiogenesis.

Zhao H, Ahirwar DK, Oghumu S, Wilkie T, Powell CA, Satoskar AR, Li DY, Ganju RK, Zhao H, Ahirwar DK, Oghumu S, Wilkie T, Powell CA, Nasser MW, Satoskar AR, Li DY, Ganju RK

Mol Oncol 10 272-81 02/01/2016
Endothelial Robo4 suppresses breast cancer growth and metastasis through regulation of tumor angiogenesis.

Zhao H, Ahirwar DK, Oghumu S, Wilkie T, Powell CA, Satoskar AR, Li DY, Ganju RK, Zhao H, Ahirwar DK, Oghumu S, Wilkie T, Powell CA, Nasser MW, Satoskar AR, Li DY, Ganju RK

Mol Oncol 10 272-81 02/01/2016
A Novel Sterol Isolated from a Plant Used by Mayan Traditional Healers Is Effective in Treatment of Visceral Leishmaniasis Caused by Leishmania donovani.

Gupta G, Peine KJ, Abdelhamid D, Snider H, Shelton AB, Rao L, Kotha SR, Huntsman AC, Varikuti S, Oghumu S, Naman CB, Pan L, Parinandi NL, Papenfuss TL, Kinghorn AD, Bachelder EM, Ainslie KM, Fuchs JR, Satoskar AR

ACS Infect Dis 1 497-506 10/09/2015
Modulation of the tumor microenvironment and inhibition of EGF/EGFR pathway: novel anti-tumor mechanisms of Cannabidiol in breast cancer.

Elbaz M, Nasser MW, Ravi J, Wani NA, Ahirwar DK, Zhao H, Oghumu S, Satoskar AR, Shilo K, Carson WE, Ganju RK, Elbaz M, Nasser MW, Ravi J, Wani NA, Ahirwar DK, Zhao H, Oghumu S, Satoskar AR, Shilo K, Carson WE 3rd, Ganju RK

Mol Oncol 9 906-19 04/01/2015

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Steve Oghumu, PhD

College

Academic Title

Research Program

Education and Background

Office Location

Publications

Ly6C(hi) inflammatory monocytes promote susceptibility to Leishmania donovani infection.

Pentalinonsterol, a Constituent of Pentalinon andrieuxii, Possesses Potent Immunomodulatory Activity and Primes T Cell Immune Responses.

In situ immunopathological changes in cutaneous leishmaniasis due to Leishmania donovani.

In situ immunopathological changes in cutaneous leishmaniasis due to Leishmania donovani.

Helminth-induced Ly6C(hi) monocyte-derived alternatively activated macrophages suppress experimental autoimmune encephalomyelitis.

STAT1 gene deficient mice develop accelerated breast cancer growth and metastasis which is reduced by IL-17 blockade.

Inhibition of Pro-inflammatory and Anti-apoptotic Biomarkers during Experimental Oral Cancer Chemoprevention by Dietary Black Raspberries.

STAT4 is required for the generation of Th1 and Th2, but not Th17 immune responses during monophosphoryl lipid A adjuvant activity.

Transgenic T cell-specific expression of CXCR3 enhances splenic and hepatic T cell accumulation but does not affect the outcome of visceral leishmaniasis.

Deletion of macrophage migration inhibitory factor inhibits murine oral carcinogenesis: Potential role for chronic pro-inflammatory immune mediators.

Differential gene expression pattern in biopsies with renal allograft pyelonephritis and allograft rejection.

Pediatric Cutaneous Leishmaniasis in an Endemic Region in Turkey: A Retrospective Analysis of 8786 Cases during 1998-2014.

A Tec kinase BTK inhibitor ibrutinib promotes maturation and activation of dendritic cells.

Host-mediated Leishmania donovani treatment using AR-12 encapsulated in acetalated dextran microparticles.

Endothelial Robo4 suppresses breast cancer growth and metastasis through regulation of tumor angiogenesis.

Endothelial Robo4 suppresses breast cancer growth and metastasis through regulation of tumor angiogenesis.

A Novel Sterol Isolated from a Plant Used by Mayan Traditional Healers Is Effective in Treatment of Visceral Leishmaniasis Caused by Leishmania donovani.

Modulation of the tumor microenvironment and inhibition of EGF/EGFR pathway: novel anti-tumor mechanisms of Cannabidiol in breast cancer.

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