Susan R Mallery, DDS, PhD
College of Dentistry
Molecular Carcinogenesis and Chemoprevention
Mouth Cancer, Sarcoma, Kaposi, Carcinoma, Squamous Cell, Neovascularization, Pathologic, Neoplasm Invasiveness, Leukoplakia, Oral, Cancer, Head and Neck Cancer, Leukoplakia, Loss of Heterozygosity
Susan Mallery, DDS, PhD, is a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where her research focuses on oral pathology, oral cancer initiation and chemoprevention. She also studies AIDS-related oral cancer.Dr. Mallery is especially interested in chemoprevention approaches that use local delivery formulations to apply natural products and biologics directly to the affected site on the oral epithelial. One of her recent studies reinforced pilot research that identified black raspberry gel on oral intraepithelial neoplasia lesions as a therapeutic agent. It also indicated that the therapeutic effects of black raspberry gel can be expanded to include improvements in histologic grade and lesion size. With help from a Pelotonia Idea Grant, Dr. Mallery and her colleagues are developing nanoparticles that carry two complementary chemopreventive agents. The particles are designed to adhere to and be taken up by cells lining the mouth. Her team will then formulate the nanoparticles into lozenges that will dissolve, bathing the cells of the mouth with the nanoparticles. Once inside the cells, the nanoparticles will release the two chemopreventive agents, which will inhibit molecular signals that push cells to grow and divide. The goal is to keep precancerous cells from developing into oral cancer. Dr. Mallery has co-authored numerous articles in well-respected publications, such as Cancer Prevention Research, Clinical Cancer Research, Molecular Pharmaceutics and Carcinogenesis.