Susanne I Wells, PhD
College of Medicine - UC
Dr. Wells' research goal is to advance the understanding of both HPV-related and -unrelated SCC development, and to develop new approaches to the diagnosis and treatment of HPV as a major cause of cancer worldwide. Two major areas of investigation in the laboratory focus on: (1) Mechanisms by which the HPV oncogenes subvert the host cell machinery to promote abnormal cell growth and cancer and (2) The role of specific cellular HPV targets in viral replication and cellular transformation. Model systems utilized include primary human and murine cells and tumors, three-dimensional organotypic epithelial rafts and mouse models of cancer.