Takeshi Kurita, PhD
College of Medicine
Cancer Biology and Genetics
Molecular Biology and Cancer Genetics
Leiomyoma, Cancer, Metaplasia, Endometrial Cancer
Takeshi Kurita, PhD, is a member of the OSUCCC – James Molecular Biology and Cancer Genetics Program. His research explores the molecular mechanisms of development and carcinogenesis of the reproductive organs.His lab investigates these mechanisms primarily using genetically engineered mouse models. He also uses the xenograft model of human tissue to research the etiology of human diseases such as uterine leiomyoma and endometrial cancer. Dr. Kurita is the first researcher who experimentally demonstrated that uterine leiomyoma (fibroid) is a progesterone-dependent tumor. Recent studies from his group explain that growth control of most uterine leiomyoma cases involves complex tissue interactions among multiple cell types. He also defined the cellular origin of vaginal epithelium utilizing a mouse cell lineage tracing method. Recent studies from his group identified the molecular mechanisms that control epithelial cell fate in the vagina, the disruption of which can result in a rare type of cancer. In addition, Dr. Kurita’s group recently discovered a novel pathway through which chemotherapies destroy the ovarian reserve and a method to block the death pathway for female fertility preservation. Dr. Kurita has co-authored more than 50 articles and book chapters. They have appeared in well-respected journals, such as Cancer Research, Cell Death and Differentiation, Development and Endocrinology.