Tatiana Kalin, MD, PhD
College of Medicine - UC
Molecular Biology and Cancer Genetics
multiple transgenic and knockout mouse models to study the specific role of several transcription factors in different cell populations, including lung epithelial cells, macrophages, fibroblasts, pericytes and endothelial cells. My laboratory is interested in identifying critical regulatory interactions during the cross-talk between tumor cells and cells of tumor microenvironment with the long-term goal to develop new therapies to treat human lung diseases. We identified multiple signaling pathways involved in these cellular interactions and several Forkhead-box transcription factors regulating these signaling pathways. Based on these data we are developing new therapeutic approaches to target tumor-microenvironment in cancer. We have also developed several biomarkers to predict tumor responses to chemotherapy and assess lung toxicity and fibrotic responses after thoracic irradiation.