Terence M Williams, MD, PhD

Terence Williams

College

College of Medicine

Department/Division

Radiation Oncology

Academic Title

Assoc Professor

Research Program

Molecular Biology and Cancer Genetics

Leadership Title

Williams Lab

Research Interest

Cancer ● Pancreatic Cancer ● Glioblastoma ● Breast Cancer ● Neoplasm Metastasis ● Prostatic Cancer ● Carcinoma, Non-Small-Cell Lung ● Leukemia ● Adenocarcinoma ● Glioma

As a member of the Molecular Biology and Cancer Genetics Program at the OSUCCC – James, Terrence Williams, MD, PhD, focuses his research primarily on thoracic and gastrointestinal malignancies and thyroid cancer.

Dr. Williams’ laboratory focuses on DNA damage response pathways, radiation and chemotherapy resistance, biologic markers for therapeutic response, molecular profiling and novel mechanisms of radiosensitization. In particular, the lab is focused on the molecular biology and genetics that govern response to treatment, particularly with chemotherapy and radiation. Knowledge of the genetics and molecular biology prior to treatment, and the manner in which activation of these biologic pathways changes after treatment, could potentially lead to identification of predictive biomarkers of response to therapy or identify novel resistance pathways which could then be targeted to improve cancer control. Thus, the goals of current projects in the lab are to identify novel therapies, targets and biomarkers of response to radiation in combination with other therapies, including chemotherapy or molecularly-targeted agents.

Active research projects include investigating oncogene-mediated radioresistance; studying caveolins and caveolae-related endocytosis and their importance with regards to tumor progression and response to therapy; the rational development of novel therapeutic combinations of molecularly-targeted agents and radiation; molecular profiling of lung and gastrointestinal (GI) malignancies using systems-based approaches to prognosticate and predict clinical outcomes; and novel DNA repair pathways and their relationship to cancer development and therapeutic response.

Dr. Williams has shared his research in presentations and co-authored more than 70 articles appearing in such well-respected publications as Journal of Clinical Oncology, Cancer Research, Molecular Cancer Therapeutics and Clinical Cancer Research.


Education

  • BA, Haverford College

    Haverford, PA (USA)

  • Fellowship, AECOM

  • Fellowship, University of Michigan Health Systems

    Ann Arbor, MI (USA)

Residencies

  • Chief Resident, Radiation Oncology

    University of Michigan Health System

    Ann Arbor, MI (USA)

  • Internal Medicine Internship

    University of Michigan Health System

    Ann Arbor, MI (USA)

  • Radiation Oncology Resident

    University of Michigan Health System

    Ann Arbor, MI (USA)

Fellowship

  • Postdoctoral Research Fellow

    AECOM

  • Postdoctoral Research Fellow

    University of Michigan Health Systems

    Ann Arbor, MI (USA)

Office Location

James Cancer Hosp & Res Inst

300 W 10th Ave, Columbus, OH 43210


614-293-8415

614-293-4044



Publications

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