Traci A Wilgus, PhD
College of Medicine
Molecular Carcinogenesis and Chemoprevention
Wounds and Injuries, Inflammation, Cancer, Skin Cancer, Edema, Leg Ulcer, Varicose Ulcer, Sunburn, Papilloma, Choroidal Neovascularization
Dr. Wilgus studies the involvement of the pro-angiogenic growth factor vascular endothelial growth factor (VEGF) in skin carcinogenesis. VEGF is known to contribute to skin carcinogenesis by enhancing angiogenesis. Her lab has found that VEGFR-1 (VEGF receptor-1) is expressed by normal epidermal keratinocytes and tumor cells from non-melanoma skin cancers. Studies are underway to determine whether VEGF can directly influence these cells by signaling through VEGFR-1, and the potential importance of epithelial VEGFR-1 signaling for the growth and development of skin tumors.