Tsonwin Hai, PhD
College of Medicine
Biological Chemistry & Pharmacology
Molecular Biology and Cancer Genetics
Cancer, Endoplasmic Reticulum Stress, Prostatic Cancer, Cardiomegaly
Maladaptation of cells to various signals plays important roles in the pathogenesis of many diseases. The current focus of my laboratory is to study the maladaptive processes in the development of breast cancer, melanoma, and diabetes. In all three cases, inflammatory signals exacerbate the diseases. We are investigating how inflammatory signals in conjunction with other stress signals affect various cellular machineries that regulate signal transduction, gene expression, apoptosis, cell migration, angiogenesis, metastasis, and cell-cell interactions. The approach we take is to focus on a stress-inducible gene ATF3, which encodes a member of the ATF/CREB transcription factors and functions as a “hub” of the cellular adaptive-response networks. Our strategy is to use ATF3 — as a handle — to probe the stress responses and gain insights to the roles of cellular adaptations to stress signals in the development of above diseases. For more information, see http://cmn.osu.edu/1493.cfm.