Vinay K Puduvalli, MD

Vinay Puduvalli


College of Medicine



Academic Title


Research Program

Translational Therapeutics

Research Interest

Glioma, Glioblastoma, Cancer, Astrocytoma, Meningioma, Brain Cancer, Neoplasm Metastasis, Leukemia, Lymphocytic, Chronic, B-Cell, Oligodendroglioma, fatigue

Dr. Puduvalli's academic interests are directed towards patient oriented research in preclinical, translational and clinical studies. He has initiated a comprehensive effort to study epigenetic modulation of targeted therapies against malignant gliomas. A proposed project is based on preclinical rationale for synergistic interaction and will examine the clinical effects of combining bevacizumab and vorinostat in a unique Bayesian adaptive randomized “pick the winner” 2 arm phase II trial. Dr. Puduvalli's lab is focused on characterizing epigenetic changes of clinical relevance in gliomas and glioma stem cells (GSC) by identifying epigenetic changes in gliomas as follows- 1) Epigenetic characterization of GSC by determining key promoter level interactions of DNA methylation with the stemness genes that regulate their expression with the goal to identify epigenetic switches governing stem to differentiated states and identify novel therapeutic targets. 2) Characterizing chromatin modification and the role of HDAC in stemness and drug resistance in glioma stem cells. 3) drug development and translational studies in gliomas. These studies are aimed at providing new insights into epigenetics and drug resistance of gliomas.


  • MD, Bangalore Medical College

    Bangalore (India)

  • Fellowship, National Institute of Mental Health & Neurosciences

    Bangalore (INDIA)

  • Fellowship, The University of Texas MD Anderson Cancer Center

    Houston, TX (USA)


  • Internal Medicine Internship

    Texas Tech University

    Amarillo, TX (USA)

  • Neurology Residency

    The University of Texas Health Sciences Center

    Houston, TX (USA)


  • Clinical Fellowship, Psychiatry

    National Institute of Mental Health & Neurosciences

    Bangalore (INDIA)

  • Fellowship, Neuro-Oncology

    The University of Texas MD Anderson Cancer Center

    Houston, TX (USA)

Office Location

M410 Starling Loving Hall

320 W 10th Ave, Columbus, OH 43210




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