Vinay K Puduvalli, MD

Vinay Puduvalli


College of Medicine


Neurological Surgery

Academic Title


Research Program

Translational Therapeutics

Research Interest

Glioma ● Glioblastoma ● Cancer ● Astrocytoma ● Meningioma ● Brain Cancer ● Neoplasm Metastasis ● Leukemia, Lymphocytic, Chronic, B-Cell ● Oligodendroglioma ● Fatigue

Vinay Puduvalli, MBBS, is a member of the Translational Therapeutics Program at the OSUCCC – James, where he focuses on patient-oriented research in preclinical, translational and clinical studies.

He is an internationally known expert in the treatment and research of neurological malignancies and leads a comprehensive effort in the Department of Neurological Surgery to develop novel therapies against brain tumors and to study resistance mechanisms to targeted therapies against malignant gliomas through epigenetic regulators and bypass pathways involved in resistance.

His research interests include targeting novel pathway hubs that govern treatment resistance, including the PAK4-mediated signaling pathway and Hsp90 and HDAC inhibitors, as well as targeting the NAD metabolic pathways. On the clinical research side, he leads and collaborates in national multicenter trials examining clinical efficacy of novel drug combinations against malignant brain tumors. Ongoing projects include: targeting the heat shock response using Hsp90 inhibitors to overcome resistance to chemotherapy and radiation therapy; characterizing chromatin modification and the role of HDAC in stemness and drug resistance; and targeting energy metabolism pathways specific to gliomas to overcome treatment resistance.

Dr. Puduvalli has also led national multicenter trials examining synergistic interaction and clinical efficacy of combination therapies in an adaptive randomized phase II trial with correlative studies. He has nearly two decades of experience in studies related to brain tumor biology and treatments. His team has developed several preclinical models, including a human organotypic slice culture model to test the biological effects of drugs in live ex vivo human tumor specimens.

Dr. Puduvalli has co-authored more than 85 articles in well-respected peer-reviewed publications such as Clinical Cancer Research, Neurooncology, Journal of Clinical Oncology and Oncogene. He has also authored a half dozen book chapters in his field.

Additionally, he has shared his research in numerous presentations to national and international organizations, including the Society for Neurooncology, the Society for Neurooncology China, the American Society of Clinical Oncology, the American Association of Cancer Research and the Indian Society of Neurooncology.


  • MD, Bangalore Medical College

    Bangalore (India)

  • Fellowship, National Institute of Mental Health & Neurosciences

    Bangalore (INDIA)

  • Fellowship, The University of Texas MD Anderson Cancer Center

    Houston, TX (USA)


  • Internal Medicine Internship

    Texas Tech University

    Amarillo, TX (USA)

  • Neurology Residency

    The University of Texas Health Sciences Center

    Houston, TX (USA)


  • Clinical Fellowship, Psychiatry

    National Institute of Mental Health & Neurosciences

    Bangalore (INDIA)

  • Fellowship, Neuro-Oncology

    The University of Texas MD Anderson Cancer Center

    Houston, TX (USA)

Office Location

M410 Starling Loving Hall

320 W 10th Ave, Columbus, OH 43210




Back to Researcher Search

Please enter a keyword (i.e. Name, Research Interest) or choose a Research Program


Please enter a keyword (i.e. Name, Cancer Type) or choose a Principle Investigator


Search for Clinical Trials

Find a Scientific Publication