Vincenzo Coppola, MD
College of Medicine
Cancer Biology and Genetics
Molecular Biology and Cancer Genetics
Cancer ● Lymphoma ● Hyperphagia ● Tumor Virus Infections
Vincenzo Coppola, MD, is a member of the Molecular Biology and Cancer Genetics Program at the OSUCCC – James. He also directs the Genetically Engineered Mouse Modeling Core (GEMMC), a Shared Resource that is designed to assist other OSUCCC members in generating mouse models of human cancer and in studying gene functions in vivo.
In his role as principal investigator, Dr. Coppola leads a research program focused on the study of two poorly characterized proteins, IWS1 and RANBP9, in lung carcinogenesis and melanoma. IWS1 is an RNA processing factor involved in critical biological processes such as proliferation, cell survival and apoptosis. This NIH-funded investigation takes advantage of mouse models to elucidate the role of this protein in development, melanomagenesis and lung carcinogenesis in vivo (5R01CA198117).
Recently, the Coppola Lab has published evidence that another protein possibly involved in RNA processing, named RANBP9, is a facilitator of the cellular DNA damage response in non-small cell lung cancer. As such, RANBP9 might be a biomarker for clinical prediction of patient response to platinum-based drugs (Palmieri et al., 2016).
Dr. Coppola is the co-author of more than 70 peer-reviewed articles in such well-respected publications as Nature and Science, and he currently serves as an academic editor of PLOS One, Journal of Oncology and International Journal of Molecular Sciences. He is also a member of the American Association for Cancer Research and the International Mammalian Genomic Society.
MD, University “Federico II”
Fellowship, Mouse Cancer Genetics Program NCI-Frederick, MD
Frederick, MD (USA)
Residency, Medical Sciences
University of Napoli
Specialization in Oncology
University of Padova
Postdoctoral Fellow, Neural Development Group
Mouse Cancer Genetics Program NCI-Frederick, MD
Frederick, MD (USA)