Vish V Subramaniam, PhD
College of Engineering
Mechanical & Aerospace Engineering
Molecular Biology and Cancer Genetics
Vish Subramaniam, PhD, is a member of the Molecular Biology and Cancer Genetics Program at the OSUCCC – James, where he brings an engineering perspective to his research on the interactions between low-frequency electromagnetic waves and tissues and cells. This research ranges from fundamental studies to pre-clinical applications.Dr. Subramaniam’s current research is on interactions between low frequency (< 1 MHz) electromagnetic waves and tissues and cells. This research ranges from fundamental studies to pre-clinical applications. Research on electrostatic interactions governing cell migration, cell signaling, and activity of select enzymes, is used to develop new methods for detecting and imaging solid tumors, for devising means of controlling metastasis, for accelerating wound healing, and mitigating antibiotic resistant bacterial biofilms. Specifically relevant to cancer research, binding of ligands (e.g. CXCL12), growth factors (EGF), and corresponding receptors (CXCR4 and EGFR) and subsequent downstream intracellular signaling are manipulated using weak induced electric fields to affect cell migration. Current research projects include studies on the mechanisms of interaction between weak (less than 100 microVolts per cm) electric fields and intracellular signaling in cancer cells in the presence of growth factors and chemokines, development of electroceutical dressings for accelerating wound healing and remediating antibiotic-resistant bacterial biofilms, and development of a novel nano-heterolayered electrode material for photoelectochemical regeneration of cofactors (NAD(P)H) from NAD(P)+, with implications for metabolic processes in animal and plant cells. Additionally, he has co-authored numerous articles in well-respected publications, including Physiological Measurement, Scientific Reports and PLOS ONE.