Wayne Miles, PhD
College of Arts & Sciences
Molecular Biology and Cancer Genetics
Wayne Miles, PhD, is a member of the Molecular Biology and Cancer Genetics Program at the OSUCCC – James, where his research seeks to identify mechanisms that enable cancer cells to overcome cellular stresses associated with oncogenic growth.In particular, he is focused on how the loss of the retinoblastoma 1 (pRB) tumor suppressor changes the transcriptome and proteome of cancer cells. One of his recent studies identified a previously unknown additional tier of post-transcriptional regulation that constrains E2F levels and the transcriptional program up-regulated by pRB loss. Dr. Miles has co-authored numerous articles in well-respected publications, including Genes & Development, The EMBO Journal and Disease Models & Mechanisms.