Wayne Miles, PhD

Wayne Miles, PhD, is a member of the Molecular Biology and Cancer Genetics Program at the OSUCCC – James, where his research seeks to identify mechanisms that enable cancer cells to overcome cellular stresses associated with oncogenic growth.

In particular, he is focused on how the loss of the retinoblastoma 1 (pRB) tumor suppressor changes the transcriptome and proteome of cancer cells.

One of his recent studies identified a previously unknown additional tier of post-transcriptional regulation that constrains E2F levels and the transcriptional program up-regulated by pRB loss.

Dr. Miles has co-authored numerous articles in well-respected publications, including Genes & Development, The EMBO Journal and Disease Models & Mechanisms.